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Al-Badri, A. S, Ali, E. N, Ali Ajah, H [Hamzia], Ali Ajah, H [Hassan]. (1401). Effect of IL-23 Receptor Gene Polymorphism (Rs1884444) on the Prevalence of Oral Fungal Infection in Patients with Type 2 Diabetes Mellitus: A Case-Control Study in Iraqi Patients. سامانه مدیریت نشریات علمی, 77(5), 1553-1560. doi: 10.22092/ari.2022.357754.2096
A. S Al-Badri; E. N Ali; H [Hamzia] Ali Ajah; H [Hassan] Ali Ajah. "Effect of IL-23 Receptor Gene Polymorphism (Rs1884444) on the Prevalence of Oral Fungal Infection in Patients with Type 2 Diabetes Mellitus: A Case-Control Study in Iraqi Patients". سامانه مدیریت نشریات علمی, 77, 5, 1401, 1553-1560. doi: 10.22092/ari.2022.357754.2096
Al-Badri, A. S, Ali, E. N, Ali Ajah, H [Hamzia], Ali Ajah, H [Hassan]. (1401). 'Effect of IL-23 Receptor Gene Polymorphism (Rs1884444) on the Prevalence of Oral Fungal Infection in Patients with Type 2 Diabetes Mellitus: A Case-Control Study in Iraqi Patients', سامانه مدیریت نشریات علمی, 77(5), pp. 1553-1560. doi: 10.22092/ari.2022.357754.2096
Al-Badri, A. S, Ali, E. N, Ali Ajah, H [Hamzia], Ali Ajah, H [Hassan]. Effect of IL-23 Receptor Gene Polymorphism (Rs1884444) on the Prevalence of Oral Fungal Infection in Patients with Type 2 Diabetes Mellitus: A Case-Control Study in Iraqi Patients. سامانه مدیریت نشریات علمی, 1401; 77(5): 1553-1560. doi: 10.22092/ari.2022.357754.2096

Effect of IL-23 Receptor Gene Polymorphism (Rs1884444) on the Prevalence of Oral Fungal Infection in Patients with Type 2 Diabetes Mellitus: A Case-Control Study in Iraqi Patients

Archives of Razi Institute
مقاله 6، دوره 77، شماره 5، آذر و دی 2022، صفحه 1553-1560    اصل مقاله (670.42 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357754.2096
نویسندگان
A. S Al-Badri* 1؛ E. N Ali2؛ H [Hamzia] Ali Ajah2؛ H [Hassan] Ali Ajah3
1Department of Science, College of Basic Education, Wasit University, Kut, Iraq
2Department of Biology, College of Science, Mustansiryiah University, Baghdad, Iraq
3Kirkuk University, College of Medicine, Iraq
چکیده
Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder linked to several genetic disorders. Over the last decade, advancements in genetic association studies have resulted in the identification of at least 75 distinct genetic loci associated with T2DM, allowing for a better understanding of the genetic architecture of this disease. Recently, there has been a positive association between the prevalence of oral fungal infection and T2DM. The current study aimed to assess the effect of single nucleotide polymorphism in IL23R (rs1884444) on oral fungal infection and the distribution of alleles in T2DM patients compared to healthy controls. A total of 150 specimens, including oral swabs and whole blood samples, were collected from the Endocrinology and Diabetes Center in Baghdad. Oral swabs were collected via AIMS transport media. Routine tests and the Vitek 2 system carried out fungal identification; moreover, the tetra-primer amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) was used for molecular detection. The findings revealed that the O blood group was positively associated with T2DM and oral fungal infection. Moreover, the TT genotype for IL23R SNP (rs1884444G/T) increased significantly in patients, as compared to that in healthy control. Furthermore, the T allele was increased in patients suffering from T2DM (P<0.001). The GT and TT were more frequent in oral fungal infection in patients with T2DM. The TT and T alleles were positively associated with the risk of developing T2DM. Moreover, GT and TT were associated with oral fungal infection and T2DM.
کلیدواژه‌ها
IL23R.rs (rs1884444)؛ Oral fungal infection؛ Polymorphism
مراجع
  1. Punthakee Z, Goldenberg R, Katz P. Definition, Classification and Diagnosis of Diabetes, Prediabetes and Metabolic Syndrome. Can J Diabetes. 2018;42(1):10-5.
  2. Leete P, Oram RA, McDonald TJ, Shields BM, Ziller C, team Ts, et al. Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis. Diabetologia. 2020;63(6):1258-67.
  3. Verhulst MJL, Loos BG, Gerdes VEA, Teeuw WJ. Evaluating All Potential Oral Complications of Diabetes Mellitus. Front Endocrinol. 2019;10:56.
  4. Awad SF, Al-Mawali A, Al-Lawati JA, Morsi M, Critchley JA, Abu-Raddad LJ. Forecasting the type 2 diabetes mellitus epidemic and the role of key risk factors in Oman up to 2050: Mathematical modeling analyses. J Diabetes Investig. 2021;12(7):1162-74.
  5. Spindler MP, Ho AM, Tridgell D, McCulloch-Olson M, Gersuk V, Ni C, et al. Acute hyperglycemia impairs IL-6 expression in humans. Immun Inflamm Dis. 2016;4(1):91-7.
  6. van Eijkeren RJ, Morris I, Borgman A, Markovska A, Kalkhoven E. Cytokine Output of Adipocyte-iNKT Cell Interplay Is Skewed by a Lipid-Rich Microenvironment. Front Endocrinol. 2020;11:479.
  7. Lee CH, Lam KS. Obesity-induced insulin resistance and macrophage infiltration of the adipose tissue: A vicious cycle. J Diabetes Investig. 2019;10(1):29-31.
  8. Skyler JS, Bakris GL, Bonifacio E, Darsow T, Eckel RH, Groop L, et al. Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis. Diabetes. 2017;66(2):241-55.
  9. Ye L, Li L, Wan B, Yang M, Hong J, Gu W, et al. Immune response after autologous hematopoietic stem cell transplantation in type 1 diabetes mellitus. Stem Cell Res Ther. 2017;8(1):90.
  10. Ruyssen-Witrand A, Luxembourger C, Cantagrel A, Nigon D, Claudepierre P, Degboe Y, et al. Association between IL23R and ERAP1 polymorphisms and sacroiliac or spinal MRI inflammation in spondyloarthritis: DESIR cohort data. Arthritis Res Ther. 2019;21(1):22.
  11. Zhou Y, Su Y, Zhu H, Wang X, Li X, Dai C, et al. Interleukin-23 receptor signaling mediates cancer dormancy and radioresistance in human esophageal squamous carcinoma cells via the Wnt/Notch pathway. J Mol Med (Berl). 2019;97(2):177-88.
  12. Neurath MF. IL-23 in inflammatory bowel diseases and colon cancer. Cytokine Growth Factor Rev. 2019;45:1-8.
  13. Almradi A, Hanzel J, Sedano R, Parker CE, Feagan BG, Ma C, et al. Clinical Trials of IL-12/IL-23 Inhibitors in Inflammatory Bowel Disease. BioDrugs. 2020;34(6):713-21.
  14. Floss DM, Moll JM, Scheller J. IL-12 and IL-23-Close Relatives with Structural Homologies but Distinct Immunological Functions. Cells. 2020;9(10).
  15. Meng Z, Liu X, Li T, Fang T, Cheng Y, Han L, et al. The SGLT2 inhibitor empagliflozin negatively regulates IL-17/IL-23 axis-mediated inflammatory responses in T2DM with NAFLD via the AMPK/mTOR/autophagy pathway. Int Immunopharmacol. 2021;94:107492.
  16. Stoicescu M, Calniceanu H, Tig I, Nemeth S, Tent A, Popa A, et al. Significant aspects and correlation between glycemic control and generalized chronic periodontitis in type 2 diabetes mellitus patients. Exp Ther Med. 2021;22(1):671.
  17. Rimachi Hidalgo MA, Cirelli T, da Silva BR, Nicchio IG, Nepomuceno R, Orrico SRP, et al. Polymorphisms and haplotypes in the Interleukin 17 Alfa gene: potential effect of smoking habits in the association with periodontitis and type 2 diabetes mellitus. Mol Biol Rep. 2021;48(2):1103-14.
  18. Zimny M, Starczewska M, Szkup M, Karakiewicz-Krawczyk K, Grochans E, Sipak-Szmigiel O. Analysis of the Impact of Type 2 Diabetes on the Psychosocial Functioning and Quality of Life of Perimenopausal Women. Int J Environ Res Public Health. 2020;17(12).
  19. Taha IM, Abdu Allah AM, Abd El Gayed EM. Expression of toll-like receptor 4 and its connection with type 2 diabetes mellitus. Cell Mol Biol. 2018;64(13):15-20.
  20. Aggarwal T, Singh D, Sharma B, shafi Siddiqui S, Agarwal S. Association of ABO and Rh blood groups with type 2 diabetes mellitus in Muzaffarnagar city. Natl J Physiol Pharm Pharmacol. 2018;8(2):167-70.
  21. Legese B, Abebe M, Fasil A. Association of ABO and Rh Blood Group Phenotypes with Type 2 Diabetes Mellitus at Felege Hiwot Comprehensive Referral Hospital Bahir Dar, Northwest Ethiopia. Int J Chronic Dis. 2020;2020:2535843.
  1. Waseem AG, Iqbal M, Khan O, Tahir M. Association of diabetes mellitus with ABO and Rh blood groups. Ann Pak Inst Med Sci. 2012;8(2):134-6.
  2. Mandal B, Shukla R, Basu A, Sinha A, Maiti A, Bhattacharjee K. Association of ABO blood groups with type-2 diabetes mellitus and its complications. J Diabetes Metab Disord. 2018;5(1):1-7.
  3. Li M, Yue C, Jin G, Guo H, Ma H, Wang G, et al. Rs1884444 variant in IL23R gene is associated with a decreased risk in esophageal cancer in Chinese population. Mol Carcinog. 2019;58(10):1822-31.
  4. Li Y, Fang W, Jiang W, Hagen F, Liu J, Zhang L, et al. Cryptococcosis in patients with diabetes mellitus II in mainland China: 1993-2015. Mycoses. 2017;60(11):706-13.
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