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Manfi Ahmed, S, Hashim Yaseen, K, Mohammed Mahmood, M. (1401). Immunological Evaluation of Individuals Infected with Acinetobacter baumannii. سامانه مدیریت نشریات علمی, 77(5), 1813-1819. doi: 10.22092/ari.2022.357980.2126
S Manfi Ahmed; K Hashim Yaseen; M Mohammed Mahmood. "Immunological Evaluation of Individuals Infected with Acinetobacter baumannii". سامانه مدیریت نشریات علمی, 77, 5, 1401, 1813-1819. doi: 10.22092/ari.2022.357980.2126
Manfi Ahmed, S, Hashim Yaseen, K, Mohammed Mahmood, M. (1401). 'Immunological Evaluation of Individuals Infected with Acinetobacter baumannii', سامانه مدیریت نشریات علمی, 77(5), pp. 1813-1819. doi: 10.22092/ari.2022.357980.2126
Manfi Ahmed, S, Hashim Yaseen, K, Mohammed Mahmood, M. Immunological Evaluation of Individuals Infected with Acinetobacter baumannii. سامانه مدیریت نشریات علمی, 1401; 77(5): 1813-1819. doi: 10.22092/ari.2022.357980.2126

Immunological Evaluation of Individuals Infected with Acinetobacter baumannii

Archives of Razi Institute
مقاله 39، دوره 77، شماره 5، آذر و دی 2022، صفحه 1813-1819    اصل مقاله (570.27 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357980.2126
نویسندگان
S Manfi Ahmed* 1؛ K Hashim Yaseen2؛ M Mohammed Mahmood2
1Department of Dentist, Al-Rafidain University College, Baghdad, Iraq
2Biology Department, College of Science, Mustansiriyah University, Baghdad, Iraq
چکیده
Acinetobacter baumannii (A. baumannii) is a spherical rod-shaped Gram-negative non-lactose fermenting (Coccobacilli, Aerobic bacteria) bacteria. It is a member of the Moraxellacea family. A. baumannii is a pathogenic, opportunistic organism that infects humans in society and hospitals. In particular, patients with immune system defects are at risk, especially those with burn infections and those hospitalized in intensive care (ICU). It plays a vital role in many illnesses, including septicemia, pneumonia, meningitis, soft tissues, skin infection, endocarditis, and urinary tract infection (UTI). The current study included immunological evaluation of infection with A. baumannii. In the current study, 150 blood samples were obtained as follows: 100 blood samples were collected from infected individuals with A. baumannii admitted to hospitals in Baghdad. Fifty blood samples were obtained from healthy individuals and considered as the control. 10 ml of blood samples were collected from the venous blood of the participants. A. baumannii was collected and isolated from infected patients and diagnosed by traditional methods, using different culture media (MacConkey agar, blood agar, and Chromogenetic agar) and by biochemical assays, then the bacteria diagnosis was confirmed using the VITEK 2 ID-GN cards. Microscopic examination and culture diagnosis of bacteria were conducted, and the diagnosis was confirmed by complete biochemical examinations using VITEK2 Compact System. Assessments included the serum level of IL-17A and TNF-α for hospitalized patients infected with A. baumannii. The study recorded a significant increase in the serum level of IL-17A for patients infected with A. baumannii (479.83±26.21 pg/ml) compared to control subjects (69.32±4.53 pg/ml). The recorded data showed a significant increase in the serum level of TNF-α for patients infected with A. baumannii (98.05±28.89 pg/ml) compared to control (1.40±25.12 pg/ml).
کلیدواژه‌ها
IL-17A؛ TNF-α؛ Acinetobacter baumannii
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