Investigation on the effect of Rhubarb stalks extracts on mice exposed to oxidative stress

Farhan Bdaiwi, Lelas; Abd ALmunim Baker, Luma; Zuher Jalal Aldin, Shaymaa

doi:10.22092/ari.2022.358160.2164

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	Investigation on the effect of Rhubarb stalks extracts on mice exposed to oxidative stress
Archives of Razi Institute
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 02 خرداد 1401
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.358160.2164
نویسندگان
Lelas Farhan Bdaiwi ¹؛ Luma Abd ALmunim Baker²؛ Shaymaa Zuher Jalal Aldin²
¹Department of Chemistry / College of Education for Girls / Mosul University/Iraq
²Department of Chemistry / College of Education for Pure Science / Mosul University/Iraq
چکیده
Normal blood lipid levels have a crucial role in lowering cardiovascular mortality. The goal of this study was to investigate the effect of aqueous rhubarb extract on serum glucose, cholesterol, total lipids, peroxynitrate, malondialdehyde, glutathione, and ceroluplasmine levels, as well as glutathione and malondialdehyde levels in liver, kidney, and heart tissue in mice exposed to oxidative stress. 40 Balb/c mice were randomly allocated into 8 groups (n=5). Group 1: The control group was left eating feed and water without treatment for (15) days. Group 2: A group exposed to oxidative stress by giving it hydrogen peroxide at a rate of (0.5%) with drinking water for a period of (15) days. Group 3: A group exposed to oxidative stress induced by hydrogen peroxide at a rate of (0.5%) for a period of (15) days with injecting it on the seventh day, daily for a week, with insulin subcutaneously (15) units/kg. Group (4-8): the Groups were exposed to the oxidative stress induced by hydrogen peroxide (0.5%) for a period of 15 days with injecting them on the seventh day into the peritoneal cavity with both the cold aqueous and non-protein extract, the extract of flavonoids at a dose of 400, 400, 0. 4,8. 8, 1.96 mg/kg body weight, respectively. All of the animals were anesthetized in the last day of the experiment, blood samples were obtained for biochemical testing, and tissue samples from the livers were collected for research. The results revealed that the cold crude aqueous, non proteinous extracts, flavonoids , proteinous precipitate and proteinous compound caused a significant decrease (p<0.05 ) in serum glucose, cholesterol, total lipids, peroxynitrate, malonaldialdehyde levels in kidney, liver, and heart. The recorded data showed a significant increase (p<0.05 ) in serum glutathione and ceroluplasmine in serum and glutathione levels in liver, kidney, and heart tissues in male mice exposed to oxidative stress. The results showed that all Rhubarb extract have an antioxidant effect in mice exposed to oxidative stress.
کلیدواژه‌ها
oxidative stress؛ antioxidant؛ Rhubarb

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Investigation on the effect of Rhubarb stalks extracts on mice exposed to oxidative stress