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Dawod Farhan, A, AL-Bayati, N. Y. (1401). Reduce the Changes in Histological Features of Colon Resulting from Induced Ulcerative Colitis in Mice by Worm Antigens. سامانه مدیریت نشریات علمی, 77(5), 1995-1999. doi: 10.22092/ari.2022.358336.2198
A Dawod Farhan; N. Y AL-Bayati. "Reduce the Changes in Histological Features of Colon Resulting from Induced Ulcerative Colitis in Mice by Worm Antigens". سامانه مدیریت نشریات علمی, 77, 5, 1401, 1995-1999. doi: 10.22092/ari.2022.358336.2198
Dawod Farhan, A, AL-Bayati, N. Y. (1401). 'Reduce the Changes in Histological Features of Colon Resulting from Induced Ulcerative Colitis in Mice by Worm Antigens', سامانه مدیریت نشریات علمی, 77(5), pp. 1995-1999. doi: 10.22092/ari.2022.358336.2198
Dawod Farhan, A, AL-Bayati, N. Y. Reduce the Changes in Histological Features of Colon Resulting from Induced Ulcerative Colitis in Mice by Worm Antigens. سامانه مدیریت نشریات علمی, 1401; 77(5): 1995-1999. doi: 10.22092/ari.2022.358336.2198

Reduce the Changes in Histological Features of Colon Resulting from Induced Ulcerative Colitis in Mice by Worm Antigens

Archives of Razi Institute
مقاله 60، دوره 77، شماره 5، آذر و دی 2022، صفحه 1995-1999    اصل مقاله (526.35 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.358336.2198
نویسندگان
A Dawod Farhan* 1؛ N. Y AL-Bayati2
1Department of Biology, College of Sciences, Diyala University, Baqubah, Iraq
2Department of Biology, College of Education for Pure Sciences, Diyala University, Baqubah, Iraq
چکیده
Ulcerative colitis is one of the inflammatory bowel disease (IBD) consequences characterized by chronic inflammation of the gastrointestinal (GI) tract. The current study aims to determine the changes in colon tissue caused by induced Ulcerative Colitis and reduce these changes by worms' antigen. The study included 45 adult male albino mice (Mus musculus), with ages ranging between 8-10 weeks; the average weights ranged between 18-32 g. Ulcerative colitis was induced by intracolonic administration of 100 μL of 4% after they had been starved for 18 h. The animals were dissected after one week, and routine histological sections were conducted. The results of the histological study showed that in the colon of white mice treated with 4% acetic acid occurred, many histological changes were represented by the appearance of inflammatory cells in the mucous layer around the goblet cells, and the formation of vacuoles, necrosis at epithelium and intense congestion under the surface epithelium. The marked histological sections of the colon in mice with induced ulcerative colitis treated with helminth extract at a concentration of 0.1 mg/kg for a week, were showed that the histological changes began to decrease in the colon tissue, with the presence of a few inflammatory cells as well as little mucus secretion.
کلیدواژه‌ها
ulcerative colitis؛ mice؛ acetic acid
مراجع
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