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Alhilali, M. J, Parham, A, Attaranzadeh, A, Amirian, M, Azizzadeh, M. (1401). Polycystic Ovary Syndrome Develops the Complications of Assisted Reproductive Technologies. سامانه مدیریت نشریات علمی, 77(4), 1467-1472. doi: 10.22092/ari.2022.358889.2329
M. J Alhilali; A Parham; A Attaranzadeh; M Amirian; M Azizzadeh. "Polycystic Ovary Syndrome Develops the Complications of Assisted Reproductive Technologies". سامانه مدیریت نشریات علمی, 77, 4, 1401, 1467-1472. doi: 10.22092/ari.2022.358889.2329
Alhilali, M. J, Parham, A, Attaranzadeh, A, Amirian, M, Azizzadeh, M. (1401). 'Polycystic Ovary Syndrome Develops the Complications of Assisted Reproductive Technologies', سامانه مدیریت نشریات علمی, 77(4), pp. 1467-1472. doi: 10.22092/ari.2022.358889.2329
Alhilali, M. J, Parham, A, Attaranzadeh, A, Amirian, M, Azizzadeh, M. Polycystic Ovary Syndrome Develops the Complications of Assisted Reproductive Technologies. سامانه مدیریت نشریات علمی, 1401; 77(4): 1467-1472. doi: 10.22092/ari.2022.358889.2329

Polycystic Ovary Syndrome Develops the Complications of Assisted Reproductive Technologies

Archives of Razi Institute
مقاله 20، دوره 77، شماره 4، مهر و آبان 2022، صفحه 1467-1472  XML اصل مقاله (349.44 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.358889.2329
نویسندگان
M. J Alhilali1، 2؛ A Parham email orcid 2، 3؛ A Attaranzadeh4، 5؛ M Amirian4، 5؛ M Azizzadeh6
1Department of Physiology, College of Veterinary Medicine, AlQadisiyiah University, Diwanyiah, Iraq
2Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
3Stem Cell Biology and Regenerative Medicine Research Group, Research Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran
4Milad Center for Infertility Treatment, Mashhad, Iran
5Mashhad University of Medical Sciences, Mashhad, Iran
6Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
چکیده
Ovarian hyperstimulation syndrome (OHSS) is a serious complication that remains a threat to every patient experiencing stimulation of ovulation. Polycystic ovary syndrome (PCOS) appears to be the most important predisposing factor for OHSS. The severity of OHSS is associated with the degree of the follicular response to the ovulation inducing agents. The objective of this study was to investigate the relationship between PCOS with the risk of moderate-to-severe OHSS in intracytoplasmic sperm injection treatment patients. Sixty patients in the reproductive ages (20-38), including OHSS patients and age-matched normoresponders were included in this study. Patients who had larger follicle counts on the day of hCG injection were considered at risk for developing moderate-to-severe OHSS. In addition, oocyte quality was assessed about 20-30 min after oocyte pickup. The incidence of OHSS in PCOS patients increased significantly up to 13.9 times higher than in patients without PCOS (OR=13.900; P=0.007). Moreover, moderate-to-severe OHSS increased significantly (OR=3.860; P=0.043) in patients with primary infertility than those with secondary infertility. In addition, oocyte quality was not affected with the severity of OHSS. In conclusion, the risk of moderate-to-severe OHSS is correlated with PCOS and primary infertility without affecting oocyte quality.
کلیدواژه‌ها
Polycystic ovary syndrome؛ Ovarian hyperstimulation syndrome؛ Assisted reproductive technologies؛ Intracytoplasmic sperm injection
عنوان مقاله [English]
سندرم تخمدان پلی کیستیک موفقیت باروری در فناوری های کمکی تولیدمثل را تحت تاثیر قرار می دهد
چکیده [English]
سندرم تحریک بیش از تخمدان (OHSS) یک عارضه جدی و در نتیجه تهدیدی برای هر بیمار در معرض فرایند تحریک تخمک گذاری است. به نظر می رسد سندرم تخمدان پلی کیستیک (PCOS) مهم ترین عامل مستعد کننده برای OHSS است. شدت عارضه OHSS با وضعیت پاسخ دهی فولیکول ها به عوامل القاکننده تخمک گذاری مرتبط است. هدف از این مطالعه، بررسی ارتباط بین سندرم تخمدان پلی کیستیک با خطر OHSS متوسط تا شدید در بیمارانی بود که تحت درمان با تکنیک تزریق داخل سیتوپلاسمی اسپرم (ICSI) قرار داشتند. تعداد 60 بیمار در سن باروری (20-38) شامل افراد مبتلا به OHSS و افراد با وضعیت طبیعی (از نظر پاسخ دهی به عوامل القاکننده تخمک گذاری) در این مطالعه وارد شدند. بیمارانی که در روز تزریق HCG، فولیکول بزرگتر بیشتری داشتند به عنوان افراد در معرض ابتلا به شکل متوسط تا شدید OHSS در نظر گرفته شدند. علاوه بر این، کیفیت اووسیت حدود 20-30 دقیقه پس از اخذ تخمک مورد قرار گرفت. شیوع OHSS در بیماران مبتلا به PCOS به طور قابل توجهی (13/9 برابر) بیشتر از افراد بدون PCOS بود (OR = 13.900؛ P=0.007). همچنین، شیوع OHSS متوسط تا شدید در بیماران مبتلا به ناباروری اولیه در مقایسه با بیماران مبتلا به ناباروری ثانویه به طور قابل توجهی بیشتر بود (OR=3.860; P=0.043). با این حال، کیفیت اووسیت تحت تاثیر شدت OHSS قرار نگرفته بود. لذا می توان چنین نتیجه گرفت که خطر وقوع OHSS متوسط تا شدید با PCOS و ناباروری اولیه در ارتباط است ولی این بیماری تاثیری بر روی کیفیت اووسیت ندارد.
کلیدواژه‌ها [English]
سندرم تخمدان پلی کیستیک, سندرم تحریک بیش از تخمدان, فناورى های کمک بارورى, تزریق داخل سیتوپلاسمی اسپرم
مراجع
  1. Alper MM, Smith LP, Sills ES. Ovarian hyperstimulation syndrome: current views on pathophysiology, risk factors, prevention, and management. J Exp Clin Assist Reprod. 2009;6:3-.
  2. Grossman LC, Michalakis KG, Browne H, Payson MD, Segars JH. The pathophysiology of ovarian hyperstimulation syndrome: an unrecognized compartment syndrome. Fertil Steril. 2010;94(4):1392-8.
  3. Marak CP, Chopra A, Alappan N, Ponea AM, Guddati AK. Ovarian hyperstimulation syndrome as an etiology of obstructive uropathy. Case Rep Obstet Gynecol. 2013;2013:653704.
  4. Humaidan P, Nelson SM, Devroey P, Coddington CC, Schwartz LB, Gordon K, et al. Ovarian hyperstimulation syndrome: review and new classification criteria for reporting in clinical trials. Hum Reprod. 2016;31(9):1997-2004.
  5. Shields R, Vollenhoven B, Ahuja K, Talmor A. Ovarian hyperstimulation syndrome: A case control study investigating risk factors. Aust N Z J Obstet Gynaecol. 2016;56(6):624-7.
  6. Haas J, Baum M, Meridor K, Hershko-Klement A, Elizur S, Hourvitz A, et al. Is severe OHSS associated with adverse pregnancy outcomes? Evidence from a case-control study. Reprod Biomed Online. 2014;29(2):216-21.
  7. Mohamed K, Saad A. Calcium Dobesilate versus Cabergoline for Prevention of Ovarian Hyper Stimulation Syndrome. Perspect Sex Reprod Health. 2017.
  8. Nastri CO, Teixeira DM, Moroni RM, Leitao VM, Martins WP. Ovarian hyperstimulation syndrome: pathophysiology, staging, prediction and prevention. Ultrasound Obstet Gynecol. 2015;45(4):377-93.
  9. Larsen U. Research on infertility: which definition should we use? Fertil Steril. 2005;83(4):846-52.
  10. Niu Z, Ye Y, Xia L, Feng Y, Zhang A. Follicular fluid cytokine composition and oocyte quality of polycystic ovary syndrome patients with metabolic syndrome undergoing in vitro fertilization. Cytokine. 2017;91:180-6.
  11. Giovanni Artini P, Monteleone P, Parisen Toldin MR, Matteucci C, Ruggiero M, Cela V, et al. Growth factors and folliculogenesis in polycystic ovary patients. Expert Rev Endocrinol Metab. 2007;2(2):215-23.
  12. Papanikolaou EG, Pozzobon C, Kolibianakis EM, Camus M, Tournaye H, Fatemi HM, et al. Incidence and prediction of ovarian hyperstimulation syndrome in women undergoing gonadotropin-releasing hormone antagonist in vitro fertilization cycles. Fertil Steril. 2006;85(1):112-20.
  13. Sun B, Ma Y, Li L, Hu L, Wang F, Zhang Y, et al. Factors Associated with Ovarian Hyperstimulation Syndrome (OHSS) Severity in Women With Polycystic Ovary Syndrome Undergoing IVF/ICSI. Front Endocrinol. 2020;11:615957.
  14. Xu GF, Zhou CL, Xiong YM, Li JY, Yu TT, Tian S, et al. Reduced Intellectual Ability in Offspring of Ovarian Hyperstimulation Syndrome: A Cohort Study. EBioMedicine. 2017;20:263-7.
  15. Rotterdam EA-SPCWG. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81(1):19-25.
  16. Alhilali MJS, Parham A, Attaranzadeh A, Amirian M, Azizzadeh M. IL-5 in follicular fluid as a negative predictor of the intracytoplasmic sperm injection outcome. Cytokine. 2019;113:265-71.
  17. Kahnberg A, Enskog A, Brannstrom M, Lundin K, Bergh C. Prediction of ovarian hyperstimulation syndrome in women undergoing in vitro fertilization. Acta Obstet Gynecol Scand. 2009;88(12):1373-81.
  18. Delvigne A. Epidemiology of OHSS. Reprod Biomed Online. 2009;19(1):8-13.
  19. Griesinger G, Verweij PJ, Gates D, Devroey P, Gordon K, Stegmann BJ, et al. Prediction of Ovarian Hyperstimulation Syndrome in Patients Treated with Corifollitropin alfa or rFSH in a GnRH Antagonist Protocol. PloS One. 2016;11(3):0149615.
  20. Schirmer DA, 3rd, Kulkarni AD, Zhang Y, Kawwass JF, Boulet SL, Kissin DM. Ovarian hyperstimulation syndrome after assisted reproductive technologies: trends, predictors, and pregnancy outcomes. Fertil Steril. 2020;114(3):567-78.
  21. Wu G, Bersinger NA, Mueller MD, von Wolff M. Intrafollicular inflammatory cytokines but not steroid hormone concentrations are increased in naturally matured follicles of women with proven endometriosis. J Assist Reprod Genet. 2017;34(3):357-64.
  22. Costello MF, Chew CYM, Lindsay K, Wang A, McNally G. Effect of polycystic ovaries on in vitro fertilization and intra-cytoplasmic sperm injection treatment outcome. Asian Pac J Reprod. 2016;5(3):182-7.
  23. Ashrafi M, Bahmanabadi A, Akhond MR, Arabipoor A. Predictive factors of early moderate/severe ovarian hyperstimulation syndrome in non-polycystic ovarian syndrome patients: a statistical model. Arch Gynecol Obstet. 2015;292(5):1145-52.
  24. Bhavsar PN, Padwal NJ, Bhide M, Ghagare SP, Joshi AR, Karnik ND. Life-threatening Medical Complications Due to Ovarian Hyperstimulation Syndrome: A Hidden Etiology. J Assoc Physicians India. 2017;65(11):87-91.
  25. Chung M-T, Wu S-P, Huang Y-C, Liu J-Y, Wu G-J. Relationship Between Cytokines in Ascites and the Severity of Ovarian Hyperstimulation Syndrome: A Case Report. Taiwan J Obstet Gynecol. 2004;43(2):107-9.
  26. Valckx SD, De Pauw I, De Neubourg D, Inion I, Berth M, Fransen E, et al. BMI-related metabolic composition of the follicular fluid of women undergoing assisted reproductive treatment and the consequences for oocyte and embryo quality. Hum Reprod. 2012;27(12):3531-9.
  27. Shi SL, Peng ZF, Yao GD, Jin HX, Song WY, Yang HY, et al. Expression of CD11c+HLA-DR+dendritic cells and related cytokines in the follicular fluid might be related to pathogenesis of ovarian hyperstimulation syndrome. Int J Clin Exp Pathol. 2015;8(11):15133-7.
  28. Geary TW, Smith MF, MacNeil MD, Day ML, Bridges GA, Perry GA, et al. Triennial Reproduction Symposium: influence of follicular characteristics at ovulation on early embryonic survival. J Anim Sci. 2013;91(7):3014-21.
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