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آمار
| تعداد نشریات | 280 |
| تعداد نشریات سازمان | 79 |
| تعداد شماره‌ها | 2,343 |
| تعداد مقالات | 27,131 |
| تعداد مشاهده مقاله | 14,936,440 |
| تعداد دریافت فایل اصل مقاله | 11,934,180 |
The impact of CD37 ectoenzyme expression in benign and malignant colorectal tumors | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 18 خرداد 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.358611.2261 | ||
| نویسندگان | ||
Noor Falih Soliman  ؛ Ban Jasim Mohamad
| ||
| University of Baghdad, Collage of science, Department of Biology, Iraq, | ||
| چکیده | ||
| The depth of invasion of colorectal cancer through the bowel wall had provided the basis for pathological staging. The establishment of prognostic markers for CRC is important in the search for potential targets for therapeutic intervention. The cell surface nucleotidase (CD73) is an enzyme involved in tumor progression and metastasis. Its main function is to convert adenosine monophosphate (AMP) to adenosine. Preclinical studies suggest that CD73 can be targeted for cancer treatment. This study investigated the prognostic value of CD73 in malignant and benign colorectal tumors among Iraqi patients and its correlation with clinicopathological features using immunohistochemistry (IHC) technique. In the current study, a total of 60 cases of formalin-fixed paraffin-embedded (FFPE) tissues of colorectal tumors were collected from Teaching Laboratories of Baghdad Medical City Teaching Hospital, Baghdad – Iraq & private labs in Baghdad. Of them, 52 were malignant, and 8 of benign cases. In addition, 10 cases of non-pathological significance of colorectal tissues were used as a control group. Results of this study revealed high significant differences (P=0.001) in the expression of CD73 between malignant tumors in comparison with benign and non-significant pathology groups. The highest expression of CD73 was detected in 76.9% of malignant cases, while in benign group, only 12.5% of cases showed weak positive expression for this marker. Furthermore, significant differences had been reported in CD73 expression with patients' age groups for malignant (P=0.0335), tumor side (P=0.0409) and tumor grade & stage (P=≤0.01). Whereas no significant differences had been seen between CD73 expression with tumor diameter and patients' gender. | ||
| کلیدواژه‌ها | ||
| CD37؛ ectoenzyme؛ colorectal tumors؛ Iraqi patients | ||
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آمار تعداد مشاهده مقاله: 6 |
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