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Gasmi Benahmed, A, Noor, S, Menzel, A, Gasmi, A. (1401). A Boolean Network Approach to Study the Mechanism Associated with Inflammatory Response Induced by Porphyromonas gingivalis. سامانه مدیریت نشریات علمی, 78(1), 1-7. doi: 10.22092/ari.2021.356604.1877
A Gasmi Benahmed; S Noor; A Menzel; A Gasmi. "A Boolean Network Approach to Study the Mechanism Associated with Inflammatory Response Induced by Porphyromonas gingivalis". سامانه مدیریت نشریات علمی, 78, 1, 1401, 1-7. doi: 10.22092/ari.2021.356604.1877
Gasmi Benahmed, A, Noor, S, Menzel, A, Gasmi, A. (1401). 'A Boolean Network Approach to Study the Mechanism Associated with Inflammatory Response Induced by Porphyromonas gingivalis', سامانه مدیریت نشریات علمی, 78(1), pp. 1-7. doi: 10.22092/ari.2021.356604.1877
Gasmi Benahmed, A, Noor, S, Menzel, A, Gasmi, A. A Boolean Network Approach to Study the Mechanism Associated with Inflammatory Response Induced by Porphyromonas gingivalis. سامانه مدیریت نشریات علمی, 1401; 78(1): 1-7. doi: 10.22092/ari.2021.356604.1877

A Boolean Network Approach to Study the Mechanism Associated with Inflammatory Response Induced by Porphyromonas gingivalis

Archives of Razi Institute
مقاله 3، دوره 78، شماره 1، فروردین و اردیبهشت 2023، صفحه 1-7    اصل مقاله (682.66 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22092/ari.2021.356604.1877
نویسندگان
A Gasmi Benahmed1؛ S Noor2؛ A Menzel3؛ A Gasmi* 4
1Académie Internationale de Médecine Dentaire Intégrative, Paris, France
2Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University Multan, Pakistan
3Laboratoires Réunis, Junglinster, Luxembourg
4Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France
چکیده
Anaerobic Porphyromonas gingivalis is a rod-shaped bacterium and is a primary agent of periodontal inflammation and thus periodontitis. This bacterium disturbs the normal flora of the oral cavity and causes dysbiosis. Databases including Google Scholar Scopus and PubMed were employed to find the evidence by using keywords like ‘Porphyromonas gingivalis,' 'Boolean network,' ‘inflammatory response and Porphyromonas gingivalis,' 'inflammation and Porphyromonas gingivalis. Only articles that reviewed the role of Porphyromonas gingivalis in oral inflammation were selected. Porphyromonas gingivalis promotes and reorganizes host immune systems against normal host flora, which causes a dysbiotic state. A reorganized immune system induces dysbiosis and periodontitis. Specifically, the role of the C5a receptor in the complement system is vital in this mechanism. P. gingivalis can change the metabolic pathways of phagocytic cells without impeding inflammation. Toll-like receptor and complement signaling are inverted by Porphyromonas gingivalis, which aids them in overcoming immunological responses. However, they sustain the inflammation process, which promotes dysbiosis. Instead of a subjective approach, a systems perspective is required to comprehend this intricate process. A Boolean network is a system approach that seems to be a better approach to understanding this complicated interaction process of Porphyromonas gingivalis with the immune system and inflammation. In short, attempts to understand the complex process using the Boolean network will ultimately help in the early detection of periodontitis, and immediate treatment can prevent soft tissue destruction and dentition loss.
کلیدواژه‌ها
Boolean network؛ Oral health؛ Porphyromonas gingivalis؛ Oral inflammation؛ the Complement system
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مراجع
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