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Gasmi, Amin, Gasmi Benahmed, Asma, Noor, Sadaf, Menzel, Alain. (1401). A Boolean network approach to study the mechanism associated with inflammatory response induced by Porphyromonas gingivalis. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2021.356604.1877
Amin Gasmi; Asma Gasmi Benahmed; Sadaf Noor; Alain Menzel. "A Boolean network approach to study the mechanism associated with inflammatory response induced by Porphyromonas gingivalis". سامانه مدیریت نشریات علمی, , , 1401, -. doi: 10.22092/ari.2021.356604.1877
Gasmi, Amin, Gasmi Benahmed, Asma, Noor, Sadaf, Menzel, Alain. (1401). 'A Boolean network approach to study the mechanism associated with inflammatory response induced by Porphyromonas gingivalis', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2021.356604.1877
Gasmi, Amin, Gasmi Benahmed, Asma, Noor, Sadaf, Menzel, Alain. A Boolean network approach to study the mechanism associated with inflammatory response induced by Porphyromonas gingivalis. سامانه مدیریت نشریات علمی, 1401; (): -. doi: 10.22092/ari.2021.356604.1877

A Boolean network approach to study the mechanism associated with inflammatory response induced by Porphyromonas gingivalis

Archives of Razi Institute
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 19 خرداد 1401  XML
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22092/ari.2021.356604.1877
نویسندگان
Amin Gasmi email orcid 1؛ Asma Gasmi Benahmedorcid 2؛ Sadaf Noor3؛ Alain Menzel4
1Société Francophone de Nutrithérapie et de Nutrigénétique Appliqu&eacut
2- Académie Internationale de Médecine Dentaire Intégrative, Paris, France - Université Claude Bernard, Villeurbanne, France
3Institute of Molecular Biology and Biotechnology, BZ University, Multan, Pakistan
4Laboratoires Réunis, Junglinster, Luxembourg
چکیده
Context: Anaerobic Porphyromonas gingivalis is a rod shape bacterium and is a primary agent of periodontal inflammation and thus periodontitis. This bacterium disturbs the normal flora of the oral cavity and causes dysbiosis. Evidence Acquisition: Databases including Google Scholar Scopus and PubMed were employed to find the evidence by using keywords like ‘Porphyromonas gingivalis’, ‘Boolean network’, ‘inflammatory response and Porphyromonas gingivalis’, ‘inflammation and Porphyromonas gingivalis. Only those articles were selected that reviewed the role of Porphyromonas gingivalis in oral inflammation. Results: Porphyromonas gingivalis promotes and reorganized host immune systems against host normal flora, which causes a dysbiotic state. A reorganized immune system induces dysbiosis and periodontitis. Specifically, the role of the C5a receptor of the complement system is very important in this mechanism. P. gingivalis can change the metabolic pathways of phagocytic cells without impeding inflammation. Toll-like receptor and complement signaling are inverted by Porphyromonas gingivalis, which aids them in overcoming immunological responses, however, they sustain the inflammation process, which promotes dysbiosis. A systems perspective, instead of a subjective approach, is required to comprehend this intricate process. A Boolean network is a system approach that seems to be a better approach to understanding this complicated interaction process of Porphyromonas gingivalis with immune system and inflammation. Conclusion: In short, attempts to understand the complex process using the Boolean network will ultimately help in the early detection of periodontitis and immediate treatment can prevent soft tissue destruction and dentition loss.
کلیدواژه‌ها
Boolean network؛ Oral health؛ Porphyromonas gingivalis؛ Oral inflammation؛ Complement system
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تعداد مشاهده مقاله: 5


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