اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,083
تعداد مقالات34,394
تعداد مشاهده مقاله48,241,635
تعداد دریافت فایل اصل مقاله78,999,405
Gasmi Benahmed, A, Noor, S, Menzel, A, Gasmi, A. (1401). A Boolean Network Approach to Study the Mechanism Associated with Inflammatory Response Induced by Porphyromonas gingivalis. سامانه مدیریت نشریات علمی, 78(1), 1-7. doi: 10.22092/ari.2021.356604.1877
A Gasmi Benahmed; S Noor; A Menzel; A Gasmi. "A Boolean Network Approach to Study the Mechanism Associated with Inflammatory Response Induced by Porphyromonas gingivalis". سامانه مدیریت نشریات علمی, 78, 1, 1401, 1-7. doi: 10.22092/ari.2021.356604.1877
Gasmi Benahmed, A, Noor, S, Menzel, A, Gasmi, A. (1401). 'A Boolean Network Approach to Study the Mechanism Associated with Inflammatory Response Induced by Porphyromonas gingivalis', سامانه مدیریت نشریات علمی, 78(1), pp. 1-7. doi: 10.22092/ari.2021.356604.1877
Gasmi Benahmed, A, Noor, S, Menzel, A, Gasmi, A. A Boolean Network Approach to Study the Mechanism Associated with Inflammatory Response Induced by Porphyromonas gingivalis. سامانه مدیریت نشریات علمی, 1401; 78(1): 1-7. doi: 10.22092/ari.2021.356604.1877

A Boolean Network Approach to Study the Mechanism Associated with Inflammatory Response Induced by Porphyromonas gingivalis

Archives of Razi Institute
مقاله 3، دوره 78، شماره 1، فروردین و اردیبهشت 2023، صفحه 1-7    اصل مقاله (682.66 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22092/ari.2021.356604.1877
نویسندگان
A Gasmi Benahmed1؛ S Noor2؛ A Menzel3؛ A Gasmi* 4
1Académie Internationale de Médecine Dentaire Intégrative, Paris, France
2Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University Multan, Pakistan
3Laboratoires Réunis, Junglinster, Luxembourg
4Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France
چکیده
Anaerobic Porphyromonas gingivalis is a rod-shaped bacterium and is a primary agent of periodontal inflammation and thus periodontitis. This bacterium disturbs the normal flora of the oral cavity and causes dysbiosis. Databases including Google Scholar Scopus and PubMed were employed to find the evidence by using keywords like ‘Porphyromonas gingivalis,' 'Boolean network,' ‘inflammatory response and Porphyromonas gingivalis,' 'inflammation and Porphyromonas gingivalis. Only articles that reviewed the role of Porphyromonas gingivalis in oral inflammation were selected. Porphyromonas gingivalis promotes and reorganizes host immune systems against normal host flora, which causes a dysbiotic state. A reorganized immune system induces dysbiosis and periodontitis. Specifically, the role of the C5a receptor in the complement system is vital in this mechanism. P. gingivalis can change the metabolic pathways of phagocytic cells without impeding inflammation. Toll-like receptor and complement signaling are inverted by Porphyromonas gingivalis, which aids them in overcoming immunological responses. However, they sustain the inflammation process, which promotes dysbiosis. Instead of a subjective approach, a systems perspective is required to comprehend this intricate process. A Boolean network is a system approach that seems to be a better approach to understanding this complicated interaction process of Porphyromonas gingivalis with the immune system and inflammation. In short, attempts to understand the complex process using the Boolean network will ultimately help in the early detection of periodontitis, and immediate treatment can prevent soft tissue destruction and dentition loss.
کلیدواژه‌ها
Boolean network؛ Oral health؛ Porphyromonas gingivalis؛ Oral inflammation؛ the Complement system
سایر فایل های مرتبط با مقاله
مراجع
  1. Samaranayake L, Matsubara VH. Normal oral flora and the oral ecosystem. Dent Clin North Am. 2017;61(2):199-215.
  2. Holt SC, Kesavalu L, Walker S, Genco CA. Virulence factors of Porphyromonas gingivalis. Periodontol 2000. 1999;20(1):168-238.
  3. Mikuls TR, Payne JB, Yu F, Thiele GM, Reynolds RJ, Cannon GW, et al. Periodontitis and Porphyromonas gingivalis in patients with rheumatoid arthritis. Arthritis Rheumatol. 2014;66(5):1090-100.
  4. Travis J, Pike R, Imamura T, Potempa J. Porphyromonas gingivalis proteinases as virulence factors in the development of periodontitis. J Periodontal Res. 1997;32(1):120-5.
  5. Hajishengallis G, Liang S, Payne MA, Hashim A, Jotwani R, Eskan MA, et al. Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe. 2011;10(5):497-506.
  6. Hajishengallis G. The inflammophilic character of the periodontitis‐associated microbiota. Mol Oral Microbiol. 2014;29(6):248-57.
  7. Maekawa T, Krauss JL, Abe T, Jotwani R, Triantafilou M, Triantafilou K, et al. Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis. Cell Host Microbe. 2014;15(6):768-78.
  8. Chen Y, Zhou R, Yi Z, Li Y, Fu Y, Zhang Y, et al. Porphyromonas gingivalis induced inflammatory responses and promoted apoptosis in lung epithelial cells infected with H1N1 via the Bcl‑2/Bax/Caspase‑3 signaling pathway. Mol Med Rep. 2018;18(1):97-104.
  9. Hu Y, Li H, Zhang J, Zhang X, Xia X, Qiu C, et al. Periodontitis induced by P. gingivalis-LPS is associated with neuroinflammation and learning and memory impairment in Sprague-Dawley rats. Front Neurol. 2020;14:658.
  10. Park MH, Park E, Kim H-J, Na HS, Chung J.

   Porphyromonas gingivalis-induced miR-132 regulates TNFα expression in THP-1 derived macrophages. SpringerPlus. 2016;5(1):1-9.

  1. Papadopoulos G, Weinberg EO, Massari P, Gibson FC, Wetzler LM, Morgan EF, et al. Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss. J Immun. 2013;190(3):1148-57.
  2. Huck O, Mulhall H, Rubin G, Kizelnik Z, Iyer R, Perpich JD, et al. Akkermansia muciniphila reduces Porphyromonas gingivalis‐induced inflammation and periodontal bone destruction. J Clin Periodontol. 2020;47(2):202-12.
  3. Leira Y, Iglesias-Rey R, Gómez-Lado N, Aguiar P, Sobrino T, D’Aiuto F, et al. Periodontitis and vascular inflammatory biomarkers: an experimental in vivo study in rats. Odontology. 2020;108(2):202-12.
  4. Ding P-H, Yang M-X, Wang N-N, Jin L-J, Dong Y, Cai X, et al. Porphyromonas gingivalis-induced NLRP3 inflammasome activation and its downstream interleukin-1β release depend on caspase-4. Front Microbiol. 2020;11:1881.
  5. Lee HA, Song YR, Park MH, Chung HY, Na HS, Chung J. Catechin ameliorates Porphyromonas gingivalis‐induced inflammation via the regulation of TLR2/4 and inflammasome signaling. J Periodontol. 2020;91(5):661-70.
  6. Jun HK, An SJ, Kim HY, Choi BK. Inflammatory response of uric acid produced by Porphyromonas gingivalis gingipains. Mol Oral Microbiol. 2020;35(5):222-30.
  7. Gu J-y, Liu Y-j, Zhu X-q, Qiu J-y, Sun Y. Effects of endotoxin tolerance induced by Porphyromonas gingivalis lipopolysaccharide on inflammatory responses in neutrophils. Inflammation. 2020;43:1692-706.
  8. Damgaard C, Kantarci A, Holmstrup P, Hasturk H, Nielsen CH, Van Dyke TE. Porphyromonas gingivalis‐induced production of reactive oxygen species, tumor necrosis factor‐α, interleukin‐6, CXCL 8 and CCL 2 by neutrophils from localized aggressive periodontitis and healthy donors: modulating actions of red blood cells and resolvin E1. J Periodontal Res. 2017;52(2):246-54.
  9. Kauffman S. Homeostasis and differentiation in random genetic control networks. Nature. 1969;224(5215):177-8.
20.          Bock M, Scharp T, Talnikar C, Klipp E. BooleSim: an interactive Boolean network simulator. Bioinformatics. 2014;30(1):131-2. 

آمار
تعداد مشاهده مقاله: 3,012
تعداد دریافت فایل اصل مقاله: 6,592


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب