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Hussein Naser, I, Aziz, N. D, Abed Al-Kareem, Z. (1401). The Protective Effect of Turmeric against Carbimazole Induced Toxicity in Male Rats. سامانه مدیریت نشریات علمی, 77(6), 2081-2087. doi: 10.22092/ari.2022.358130.2156
I Hussein Naser; N. D Aziz; Z Abed Al-Kareem. "The Protective Effect of Turmeric against Carbimazole Induced Toxicity in Male Rats". سامانه مدیریت نشریات علمی, 77, 6, 1401, 2081-2087. doi: 10.22092/ari.2022.358130.2156
Hussein Naser, I, Aziz, N. D, Abed Al-Kareem, Z. (1401). 'The Protective Effect of Turmeric against Carbimazole Induced Toxicity in Male Rats', سامانه مدیریت نشریات علمی, 77(6), pp. 2081-2087. doi: 10.22092/ari.2022.358130.2156
Hussein Naser, I, Aziz, N. D, Abed Al-Kareem, Z. The Protective Effect of Turmeric against Carbimazole Induced Toxicity in Male Rats. سامانه مدیریت نشریات علمی, 1401; 77(6): 2081-2087. doi: 10.22092/ari.2022.358130.2156

The Protective Effect of Turmeric against Carbimazole Induced Toxicity in Male Rats

Archives of Razi Institute
مقاله 9، دوره 77، شماره 6، بهمن و اسفند 2022، صفحه 2081-2087    اصل مقاله (809.78 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.358130.2156
نویسندگان
I Hussein Naser1؛ N. D Aziz* 1؛ Z Abed Al-Kareem2
1Department of Clinical Pharmacy, College of Pharmacy, University of Kerbala, Kerbala, Iraq
2Department of Pharmacology and Toxicology, College of Pharmacy, University of Kerbala, Kerbala, Iraq
چکیده
Carbimazole is a widespread drug utilized for treating hyperthyroidism. However, carbimazole usage could be associated with adverse effects such as liver damage and nephritis in rats. At the same time, turmeric, as a medical plant, has many antioxidant effects against liver and kidney toxicity. This study aimed to explore the protective effect of turmeric against carbimazole–induced toxicity in rats. The experiment was carried out on 24 male Wistar rats. They were separated into four groups, each with six animals, as follows: 1. Control group: represents a healthy animal, and each rat is only given standard food and distilled water for 30 days. 2. Carbimazole group: drenched orally 0.5 mg carbimazole daily for 30 days. 3. Turmeric group: drenched orally 100 mg turmeric powder daily for 30 days. 4. Carbimazole and turmeric group: drenched orally carbimazole 0.5 mg and turmeric 100 mg daily for 30 days. The study demonstrated a significant effect of turmeric powder in reducing the toxicity of carbimazole in both the kidney and liver biochemical parameters, in addition to the evidence of histological sections. Turmeric powder has the ability to reduce and prevent renal and hepatic toxicity induced by carbimazole overdose, which gives turmeric medical value.
کلیدواژه‌ها
Carbimazole؛ Hepatic toxicity؛ Rats؛ Renal toxicity؛ Turmeric
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مراجع
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