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Ahmed Mohammed, R, Fadheel, Q. J. (1401). Hepatoprotective Effect of Vitamin B12 in Acetaminophen Induce Hepatotoxicity in Male Rats. سامانه مدیریت نشریات علمی, 78(1), 419-425. doi: 10.22092/ari.2022.359353.2408
R Ahmed Mohammed; Q. J Fadheel. "Hepatoprotective Effect of Vitamin B12 in Acetaminophen Induce Hepatotoxicity in Male Rats". سامانه مدیریت نشریات علمی, 78, 1, 1401, 419-425. doi: 10.22092/ari.2022.359353.2408
Ahmed Mohammed, R, Fadheel, Q. J. (1401). 'Hepatoprotective Effect of Vitamin B12 in Acetaminophen Induce Hepatotoxicity in Male Rats', سامانه مدیریت نشریات علمی, 78(1), pp. 419-425. doi: 10.22092/ari.2022.359353.2408
Ahmed Mohammed, R, Fadheel, Q. J. Hepatoprotective Effect of Vitamin B12 in Acetaminophen Induce Hepatotoxicity in Male Rats. سامانه مدیریت نشریات علمی, 1401; 78(1): 419-425. doi: 10.22092/ari.2022.359353.2408

Hepatoprotective Effect of Vitamin B12 in Acetaminophen Induce Hepatotoxicity in Male Rats

Archives of Razi Institute
مقاله 52، دوره 78، شماره 1، فروردین و اردیبهشت 2023، صفحه 419-425    اصل مقاله (503.07 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359353.2408
نویسندگان
R Ahmed Mohammed* 1؛ Q. J Fadheel2
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Kufa, Kufa, Iraq
2Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Babylon, Babil, Iraq
چکیده
Acetaminophen is a pharmaceutical synthesized non-opioid analgesic that belongs to the "aniline analgesics" class of medicine. Because it lacks a significant anti-inflammatory effect, it is not classified as a non-steroidal anti-inflammatory therapeutic medication (NSAID). As an over-the-counter pain reliever and antipyretic, Acetaminophen is the active metabolite of phenacetin and acetanilide, but it is less toxic than either precursor. According to some medical studies, Acetaminophen toxicity can be treated with vitamin B12. Acetaminophen-poisoned Male Wister rats were the subject model of the current study, which examines the effects of vitamin B12 on their hepatic health. There were three groups of animals: Acetaminophen treated animals (750 ml/kg), vitamin B12-treated animals (0.63 g/kg), and a control group that received distilled water (750 ml/kg). All animals were given oral medication for seven days. On the seventh day, the animal was sacrificed. Plasma levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Glutathione (GSH), total antioxidant capacity (TAC), Caspase3, Malondialdehyde (MDA), Interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-) were measured in the cardiac blood samples. Vitamin B12 lowers liver enzyme levels in the blood, increases overall antioxidant levels, and compensates for tissue glutathione deficiency while lowering serum elevations. TNF-α and interleukin-6 levels are also reduced by caspase3. Acetaminophen-induced hepatic necrosis and inflammatory cell infiltration were both considerably reduced by vitamin B12 supplementation. According to this study, vitamin B12 was found to have a protective effect against acetaminophen-induced hepatotoxicity.
کلیدواژه‌ها
Acetaminophen؛ Hepatotoxicity؛ Vitamin B12
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مراجع
  1. Watts KT. An Evaluation of Intranasal Ketorolac in an Untreated Endodontic Pain Model: The Ohio State University; 2018.
  2. Kleiber N, Calvier E, Mooij MG, Krekels EHJ, Vaes WHJ, Tibboel D, et al. Enteral Acetaminophen Bioavailability in Pediatric Intensive Care Patients Determined With an Oral Microtracer and Pharmacokinetic Modeling to Optimize Dosing. Crit Care Med. 2019;47(12):e975-e83.
  3. Amaechi O, Human MM, Featherstone K. Pharmacologic therapy for acute pain. Am Fam Physician. 2021;104(1):63-72.
  4. Beltrán-Olazábal A, Martínez-Galán P, Castejón-Moreno R, García-Moreno ME, García-Muro C, Esteban-Zubero E. Management of acetaminophen toxicity, a review. Iberoam J Med. 2019;1(1):22-8.
  5. Jamieson MD, Everhart JS, Lin JS, Jain SA, Awan HM, Goyal KS. Reduction of Opioid Use After Upper-Extremity Surgery through a Predictive Pain Calculator and Comprehensive Pain Plan. J Hand Surg Am. 2019;44(12):1050-9 e4.
  6. Ramos-Tovar E, Muriel P. Free radicals, antioxidants, nuclear factor-E2-related factor-2 and liver damage. J Appl Toxicol. 2020;40(1):151-68.
  7. Vishnoi H, Bodla RB, Kant R, Bodla R. Green Tea (Camellia sinensis) and its antioxidant property: A review. Int J Pharm Sci Res. 2018;9(5):1723-36.
  8. Padmanabhan S, Jost M, Drennan CL, Elias-Arnanz M. A New Facet of Vitamin B(12): Gene Regulation by Cobalamin-Based Photoreceptors. Annu Rev Biochem. 2017;86:485-514.
  9. Abdulkhaleq FM, Alhussainy TM, Badr MM, Khalil AAA, Gammoh O, Ghanim BY, et al. Antioxidative stress effects of vitamins C, E, and B(12), and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats. Drug Des Devel Ther. 2018;12:3525-33.
  10. Damiano S, Muscariello E, La Rosa G, Di Maro M, Mondola P, Santillo M. Dual Role of Reactive Oxygen Species in Muscle Function: Can Antioxidant Dietary Supplements Counteract Age-Related Sarcopenia? Int J Mol Sci. 2019;20(15).
  11. Ho PC. Free from Pain or Trapped in Pain? The Role of Prescribed Opioids: Lehigh University; 2021.
  1. Offor SJ, Amadi CN, Chijioke-Nwauche I, Manautou JE, Orisakwe OE. Potential deleterious effects of paracetamol dose regime used in Nigeria versus that of the United States of America. Toxicol Rep. 2022;9:1035-44.
  2. Wang P, Cui Y, Wang J, Liu D, Tian Y, Liu K, et al. Mesenchymal stem cells protect against acetaminophen hepatotoxicity by secreting regenerative cytokine hepatocyte growth factor. Stem Cell Res Ther. 2022;13(1):94.
  3. Mas-Bargues C, Escriva C, Dromant M, Borras C, Vina J. Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease. Arch Biochem Biophys. 2021;709:108941.
  4. Nikravesh H, Khodayar MJ, Mahdavinia M, Mansouri E, Zeidooni L, Dehbashi F. Protective Effect of Gemfibrozil on Hepatotoxicity Induced by Acetaminophen in Mice: the Importance of Oxidative Stress Suppression. Adv Pharm Bull. 2018;8(2):331-9.
  5. Sedaghattalab M, Razazan M, Sadeghi H, Doustimotlagh AH, Toori MA, Abbasi Larki R, et al. Effects of Nasturtium officinale Extract on Antioxidant and Biochemical Parameters in Hemodialysis Patients: A Randomized Double-Blind Clinical Trial. Evid Based Complement Alternat Med. 2021;2021:1632957.
  6. Liao Y, Yang Y, Wang X, Wei M, Guo Q, Zhao L. Oroxyloside ameliorates acetaminophen-induced hepatotoxicity by inhibiting JNK related apoptosis and necroptosis. J Ethnopharmacol. 2020;258:112917.
  1. Shehu S, Kurya AU, Aliyu U, Sharma DC. Role of inflammatory cytokines in the pathogenesis of rheumatoid arthritis and novel therapeutic targets. Asian J Immunol. 2020:37-46.
  2. Zhao Z, Wei Q, Hua W, Liu Y, Liu X, Zhu Y. Hepatoprotective effects of berberine on acetaminophen-induced hepatotoxicity in mice. Biomed Pharmacother. 2018;103:1319-26.
  3. Han R, Zhang F, Wan C, Liu L, Zhong Q, Ding W. Effect of perfluorooctane sulphonate-induced Kupffer cell activation on hepatocyte proliferation through the NF-kappaB/TNF-alpha/IL-6-dependent pathway. Chemosphere. 2018;200:283-94.
  4. Gao RY, Wang M, Liu Q, Feng D, Wen Y, Xia Y, et al. Hypoxia-Inducible Factor-2alpha Reprograms Liver Macrophages to Protect Against Acute Liver Injury Through the Production of Interleukin-6. Hepatology. 2020;71(6):2105-17.
  5. Ye X, Li Y, Lv B, Qiu B, Zhang S, Peng H, et al. Endogenous Hydrogen Sulfide Persulfidates Caspase-3 at Cysteine 163 to Inhibit Doxorubicin-Induced Cardiomyocyte Apoptosis. Oxid Med Cell Longev. 2022;2022:6153772.
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