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آمار
| تعداد نشریات | 281 |
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Hepatoprotective Effect of Vitamin B12 in Acetaminophen Induce Hepatotoxicity in Male Rats | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 15 مرداد 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.359353.2408 | ||
| نویسندگان | ||
Rusul Ahmed Mohammed  1؛ Qayssar J. Fadheel2
| ||
| 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Kufa, Kufa, Iraq | ||
| 2Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Babylon, Babil, Iraq. | ||
| چکیده | ||
| Acetaminophen toxicity can be treated with vitamin B12, according to some medical studies. Acetaminophen poisoned rats are the subject of the current study, which examines the effects of vitamin B12 on their health. Male Wister rats were used in this research. There were three groups of animals: acetaminophen (750 ml/kg), vitamin B12 (0.63 g/kg), and distilled water (750 ml/kg). All animals were given oral medication for seven days. On the seventh day, the animal was sacrificed. The plasma levels of Alanine amino transferase (ALT), Aspartate amino transferase (AST), Glutathion (GSH), total antioxidant capacity (TAC), Caspase3, Malondialdehyde (MDA), Interlukin-6 (IL-6) and Tumor necrosis factor-alpha (TNF-α) were measured in the cardiac blood samples. Vitamin B12 lowers liver enzyme levels in the blood, increases overall antioxidant levels in the blood, and compensates for tissue glutathione deficiency while lowering serum elevations. TNF-α and interleukin-6 levels are also reduced by caspase3. Acetaminophen-induced hepatic necrosis and inflammatory cell infiltration were both considerably reduced by vitamin B12 supplementation. Vitamin B12 was found to have a protective effect against acetaminophen-induced hepatotoxicity, according to this study. | ||
| کلیدواژه‌ها | ||
| Acetaminophen؛ Hepatotoxicity؛ vitamin B12 | ||
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آمار تعداد مشاهده مقاله: 40 |
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