اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,081
تعداد مقالات34,376
تعداد مشاهده مقاله47,923,718
تعداد دریافت فایل اصل مقاله78,889,868
Widjaja, G, Ibrahim, N. J, Hadi, S. J, Cababat, F, Turki Jalil, A, Al-Charak, A. G. H, Yasin, G, Sultan, M. Q, Fakri Mustafa, Y. (1401). The Effect of Eucalyptus globulus Hydroalcoholic Extract on LH, FSH and Testosterone Concentrations and Sperm Morphology. سامانه مدیریت نشریات علمی, 78(1), 115-123. doi: 10.22092/ari.2022.359470.2426
G Widjaja; N. J Ibrahim; S. J Hadi; F Cababat; A Turki Jalil; A. G. H Al-Charak; G Yasin; M. Q Sultan; Y Fakri Mustafa. "The Effect of Eucalyptus globulus Hydroalcoholic Extract on LH, FSH and Testosterone Concentrations and Sperm Morphology". سامانه مدیریت نشریات علمی, 78, 1, 1401, 115-123. doi: 10.22092/ari.2022.359470.2426
Widjaja, G, Ibrahim, N. J, Hadi, S. J, Cababat, F, Turki Jalil, A, Al-Charak, A. G. H, Yasin, G, Sultan, M. Q, Fakri Mustafa, Y. (1401). 'The Effect of Eucalyptus globulus Hydroalcoholic Extract on LH, FSH and Testosterone Concentrations and Sperm Morphology', سامانه مدیریت نشریات علمی, 78(1), pp. 115-123. doi: 10.22092/ari.2022.359470.2426
Widjaja, G, Ibrahim, N. J, Hadi, S. J, Cababat, F, Turki Jalil, A, Al-Charak, A. G. H, Yasin, G, Sultan, M. Q, Fakri Mustafa, Y. The Effect of Eucalyptus globulus Hydroalcoholic Extract on LH, FSH and Testosterone Concentrations and Sperm Morphology. سامانه مدیریت نشریات علمی, 1401; 78(1): 115-123. doi: 10.22092/ari.2022.359470.2426

The Effect of Eucalyptus globulus Hydroalcoholic Extract on LH, FSH and Testosterone Concentrations and Sperm Morphology

Archives of Razi Institute
مقاله 16، دوره 78، شماره 1، فروردین و اردیبهشت 2023، صفحه 115-123    اصل مقاله (675.19 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359470.2426
نویسندگان
G Widjaja* 1؛ N. J Ibrahim2؛ S. J Hadi2؛ F Cababat3؛ A Turki Jalil4؛ A. G. H Al-Charak2؛ G Yasin5؛ M. Q Sultan6؛ Y Fakri Mustafa7
1Faculty of Public Health, Indonesia University, Depok, Indonesia
2Veterinary Medicine Collage, Al-Qasim Green University, Al-Qasim, Iraq
3College of Arts and Sciences, Cebu Technological University, Moalboal, Cebu, Philippines
4Faculty of Biology and Ecology, YankaKupala State University of Grodno, 230023 Grodno, Belarus
5Department of Botany, Bahauddin Zakariya University, Multan, Pakistan
6College of Dentistry, Al-Ayen University, Thi-Qar, Iraq
7Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul-41001, Iraq
چکیده
Scientists have been paying attention to the life-giving properties of medicinal plants for many years. Among these plants is the eucalyptus plant. This plant has various compounds such as cineole and terpenes. It also contains compounds such as flavonoids, aliphatic aldehydes, sesquiterpene, quinotanen, catechins, salts, and vitamins. In the present study, the hydroalcoholic extract of Eucalyptus leaves with concentrations of 175, 350, and 700 mg/kg body weight, and spermatogenesis were studied in 40 adult Wistar rats in five groups of eight. Adult male mice received the extract at the above concentrations by gavage for 28 days. Control mice received only solvent and water, while control mice received no substance other than municipal tap water and normal food. After the last administration of the drug, the animals were weighed and anesthetized, and then blood samples were taken from their hearts. Concentrations of LH, FSH, and testosterone were measured by an ELISA kit. The results showed that body weight and testis, seminiferous tube diameter, Leydig cell diameter, epithelium thickness, number of Leydig cells, spermatogonium, spermatocytes, spermatids, sperm, and testosterone concentration increased significantly with the group. But no significant difference was observed in the concentration of FSH and LH hormones or the number of Sertoli cells. Therefore, it can be concluded that eucalyptus leaf extract may increase the proliferation of sex cells in the seminiferous tubules of rats.
کلیدواژه‌ها
Hydroalcoholic extract؛ Eucalyptus leaves؛ Reproductive hormone؛ Sperm morphology
سایر فایل های مرتبط با مقاله
مراجع
  1. Vecchio MG, Loganes C, Minto C. Beneficial and healthy properties of Eucalyptus plants: A great potential use. Open Agric J. 2016;10(1).
  2. Ben Marzoug HN, Romdhane M, Lebrihi A, Mathieu F, Couderc F, Abderraba M, et al. Eucalyptus oleosa essential oils: chemical composition and antimicrobial and antioxidant activities of the oils from different plant parts (stems, leaves, flowers and fruits). Molecules. 2011;16(2):1695-709.
  3. Boukhatem MN, Amine FM, Kameli A, Saidi F, Walid K, Mohamed SB. Quality assessment of the essential oil from Eucalyptus globulus Labill of Blida (Algeria) origin. ILCPA. 2014;17.
  4. Dhakad AK, Pandey VV, Beg S, Rawat JM, Singh A. Biological, medicinal and toxicological significance of Eucalyptus leaf essential oil: a review. J Sci Food Agric. 2018;98(3):833-48.
  1. Okamura H, Mimura A, Yakou Y, Niwano M, Takahara Y. Antioxidant activity of tannins and flavonoids in Eucalyptus rostrata. Phytochemistry. 1993;33(3):557-61.
  2. Saravani K, Bameri O, Baradaran Kayal I, Ramezan Nejad P. A Review of Plants Effective Against Trichomonas vaginalis (Causative Agent of Human Infections) and Their Therapeutic Properties. J Obstet Gynecol Cancer Res. 2020;5(4):131-6.
  3. Tascini C, Ferranti S, Gemignani G, Messina F, Menichetti F. Clinical microbiological case: fever and headache in a heavy consumer of eucalyptus extract. Clin Microbiol Infect. 2002;8(7):445-6.
  4. Nagata H, Inagaki Y, Tanaka M, Ojima M, Kataoka K, Kuboniwa M, et al. Effect of eucalyptus extract chewing gum on periodontal health: a double-masked, randomized trial. J Periodontol. 2008;79(8):1378-85.
  5. Dey B, Mitra A. Chemo-profiling of eucalyptus and study of its hypoglycemic potential. World J Diabetes. 2013;4(5):170-6.
  6. Vuong QV, Chalmers AC, Jyoti Bhuyan D, Bowyer MC, Scarlett CJ. Botanical, Phytochemical, and Anticancer Properties of the Eucalyptus Species. Chem Biodivers. 2015;12(6):907-24.
  7. Pereira V, Dias C, Vasconcelos MC, Rosa E, Saavedra MJ. Antibacterial activity and synergistic effects between Eucalyptus globulus leaf residues (essential oils and extracts) and antibiotics against several isolates of respiratory tract infections (Pseudomonas aeruginosa). Ind Crops Prod. 2014;52:1-7.
  8. Mulyaningsih S, Sporer F, Zimmermann S, Reichling J, Wink M. Synergistic properties of the terpenoids aromadendrene and 1,8-cineole from the essential oil of Eucalyptus globulus against antibiotic-susceptible and antibiotic-resistant pathogens. Phytomedicine. 2010;17(13):1061-6.
  9. Nakhaee A, Bokaeian M, Saravani M, Farhangi A, Akbarzadeh A. Attenuation of oxidative stress in streptozotocin-induced diabetic rats by Eucalyptus globulus. Indian J Clin Biochem. 2009;24(4):419-25.
  10. Sharma AD. Eucalyptol (1, 8 cineole) from eucalyptus essential oil a potential inhibitor of COVID 19 corona virus infection by molecular docking studies. 2020.
  11. Ishikawa J, Shimotoyodome Y, Chen S, Ohkubo K, Takagi Y, Fujimura T, et al. Eucalyptus increases ceramide levels in keratinocytes and improves stratum corneum function. Int J Cosmet Sci. 2012;34(1):17-22.
  12. Meckfessel MH, Brandt S. The structure, function, and importance of ceramides in skin and their use as therapeutic agents in skin-care products. J Am Acad Dermatol. 2014;71(1):177-84.
  13. Murata M, Yamakoshi Y, Homma S, Aida K, Hori K, Ohashi Y. Macrocarpal A, a Novel Antibacterial Compound from Eucalyptus macrocarpa. Agric Biol Chem. 1990;54(12):3221-6.
  14. Mondal M, Quispe C, Sarkar C, Bepari TC, Alam MJ, Saha S, Ray P, Rahim MA, Islam MT, Setzer WN, Salehi B. Analgesic and anti-inflammatory potential of essential oil of Eucalyptus camaldulensis leaf: in vivo and in silico studies. Nat Prod Commun. 2021;16(4).
  15. Galan DM, Ezeudu NE, Garcia J, Geronimo CA, Berry NM, Malcolm BJ. Eucalyptol (1,8-cineole): an underutilized ally in respiratory disorders? J Essent Oil Res. 2020;32(2):103-10.
  16. Salehi B, Sharifi-Rad J, Quispe C, Llaique H, Villalobos M, Smeriglio A, et al. Insights into Eucalyptus genus chemical constituents, biological activities and health-promoting effects. Trends Food Sci Technol. 2019;91:609-24.
  17. Wong JH, Lau KM, Wu YO, Cheng L, Wong CW, Yew DT, et al. Antifungal mode of action of macrocarpal C extracted from Eucalyptus globulus Labill (Lan An) towards the dermatophyte Trichophyton mentagrophytes. Chin Med. 2015;10:34.
  18. Ebrahimi Kia F. Allelopathic effects of leaf extracts and essential oils of Eucalyptus species on weeds on crops: M. Sc thesis, Shiraz University; 2003.
  19. Arise R, Malomo S, Adebayo J, Igunnu A. Effects of aqueous extract of Eucalyptus globulus on lipid peroxidation and selected enzymes of rat liver. J Med Plant Res. 2009;3(2):077-81.
  20. Sugimoto K, Suzuki J, Nakagawa K, Hayashi S, Enomoto T, Fujita T, et al. Eucalyptus leaf extract inhibits intestinal fructose absorption, and suppresses adiposity due to dietary sucrose in rats. Br J Nutr. 2005;93(6):957-63.
  21. Al-Khazraji SM. The effect of aqueous extract of the leaves of Eucalyptus globulus on clinical laboratory parameters in alloxan induced diabetic rats. J Tech. 2009;22(4).
  22. Ismail SM. The effect of aqueous extract of the leaves of eucalyptus globules on the blood glucose level in fasted rats. Iran J Pharmacol Ther. 2007;6(2):239-0.
  23. Macleod J, Gold RZ. The male factor in fertility and infertility. II. Spermatozoon counts in 1000 men of known fertility and in 1000 cases of infertile marriage. J Urol. 1951;66(3):436-49.
  24. Dohle GR, Smit M, Weber RF. Androgens and male fertility. World J Urol. 2003;21(5):341-5.
  25. Maduro MR, Lamb DJ. Understanding new genetics of male infertility. J Urol. 2002;168(5):2197-205.
  26. Sokol RZ. Endocrinology of male infertility: evaluation and treatment. Semin Reprod Med. 2009;27(2):149-58.
  27. Shojaeepour S, Sharififar F, Haghpanah T, Iranpour M, Imani M, Dabiri S. Panax ginseng ameliorate toxic effects of cadmium on germ cell apoptosis, sperm quality, and oxidative stress in male Wistar rats. Toxin Rev. 2022;41(2):389-401.
  28. Yakubu MT. Effect of a 60-day oral gavage of a crude alkaloid extract from Chromolaena odorata leaves on hormonal and spermatogenic indices of male rats. J Androl. 2012;33(6):1199-207.
  29. Kiasalari Z, Khalili M, Roghani M, Heidari H, Azizi Y. Antiepileptic and antioxidant effect of hydroalcoholic extract of ferula assa foetida gum on pentylentetrazole-induced kindling in male mice. Basic Clin Neurosci. 2013;4(4):299.
  30. Mohammed W, Soud S, Hameed A, Hussein N. Assessment of the Cytotoxic Activity of Alcoholic Extract of Eucalyptus camaldulensis on Breast Cancer Cell Line. Arch Razi Inst. 2021;76(5):1307-14.
  31. Fenech M, Aitken C, Rinaldi J. Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis. 1998;19(7):1163-71.
  32. Hartmann A, Niess AM, Grunert-Fuchs M, Poch B, Speit G. Vitamin E prevents exercise-induced DNA damage. Mutat Res. 1995;346(4):195-202.
  33. Sram RJ, Binkova B, Rossner P, Jr. Vitamin C for DNA damage prevention. Mutat Res. 2012;733(1-2):39-49.
  34. Ristić N, Ajdžanović V, Petrović-Kosanović D, Miler M, Ušćebrka G, Milošević V. Immunohistomorphometric Changes of The Pituitary Gonadotropic Cells After Testosterone Application in a Rat Model of the Andropause. Maced Vet Rev. 2019;42(1):5-13.
  35. Silvan AM, Abad MJ, Bermejo P, Villar A. Effects of compounds extracted from Tanacetum microphyllum on arachidonic acid metabolism in cellular systems. Planta Med. 1998;64(3):200-3.
  1. Sumner H, Salan U, Knight DW, Hoult JR. Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components. Biochem Pharmacol. 1992;43(11):2313-20.
  2. Lin H, Tsai SC, Chen JJ, Chiao YC, Wang SW, Wang GJ, et al. Effects of evodiamine on the secretion of testosterone in rat testicular interstitial cells. Metabolism. 1999;48(12):1532-5.
  3. Bergh A. Local differences in Leydig cell morphology in the adult rat testis: evidence for a local control of Leydig cells by adjacent seminiferous tubules. Int J Androl. 1982;5(3):325-30.
  4. Chemes HE. Infancy is not a quiescent period of testicular development. Int J Androl. 2001;24(1):2-7.
  5. Begum MM, Sultana F. Sertoli-Leydig Cell Tumor (SLCT) of the Ovary-A Case Report. Bangladesh J Obstet Gynecol. 2017;32(2):117-20.
  6. Sajjad Y. Development of the genital ducts and external genitalia in the early human embryo. J Obstet Gynaecol Res. 2010;36(5):929-37.
  7. Liu X, Wang Z, Liu F. Chronic exposure of BPA impairs male germ cell proliferation and induces lower sperm quality in male mice. Chemosphere. 2021;262:127880.
  8. Simorangkir DR, Ramaswamy S, Marshall GR, Pohl CR, Plant TM. A selective monotropic elevation of FSH, but not that of LH, amplifies the proliferation and differentiation of spermatogonia in the adult rhesus monkey (Macaca mulatta). Hum Reprod. 2009;24(7):1584-95.
  9. Heinrich A, DeFalco T. Essential roles of interstitial cells in testicular development and function. Andrology. 2020;8(4):903-14.
  10. Chabory E, Damon C, Lenoir A, Kauselmann G, Kern H, Zevnik B, et al. Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice. J Clin Invest. 2009;119(7):2074-85.
  11. Drevet JR. The antioxidant glutathione peroxidase family and spermatozoa: a complex story. Mol Cell Endocrinol. 2006;250(1-2):70-9.
  12. Ahlem S, Khaled H, Wafa M, Sofiane B, Mohamed D, Jean-Claude M, et al. Oral administration of Eucalyptus globulus extract reduces the alloxan-induced oxidative stress in rats. Chem Biol Interact. 2009;181(1):71-6.
آمار
تعداد مشاهده مقاله: 2,859
تعداد دریافت فایل اصل مقاله: 6,220


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب