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| تعداد نشریات | 281 |
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The Impact of Human Mammary Tumor virus (HMTV) on the Expression of Epidermal growth factor receptor (EGFR) and Death –Domain associated protein (DAXX) in Breast carcinoma tissues | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 22 مرداد 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.359520.2440 | ||
| نویسندگان | ||
Hanaa Ali Naeem  ؛ wijdan Nazar Ibraheim؛ Saad Abdulbaqi Abdullah Alomar
| ||
| Department of Pathology and Forensic, College of Medicine, University of Basrah, Iraq. | ||
| چکیده | ||
| The presence and characteristics of HMTV in Iraqi breast cancer women are still unknown .Furthermore, the identification of HMTV in human breast carcinoma tissue of patients differs by country, and the factors that influence it are still unknown. In many epithelial tumor types, the EGFR and its signaling pathways outcomes are necessary for behavior of cells and regulating their proliferation , and it has been discovered that DAXX has strong carcinogenic characteristics and could be a new treatment target. This case control retrospective study investigated the presence of HMTV in paraffin embedded blocks(FFPT) of tumor samples from 60 Iraqi women patients diagnosed with primary breast cancer and 20 cases of benign tumors as control group. HMTV env sequences were identified by Real time PCR. EGFR and DAXX expression were immunodetected by immunohistochemistry technique. Chi-square test and Fishers exact test was applied for statistical analysis to compare HMTV with EGFR and DAXX expression, and other clinicopathological features of study population . P < 0.05 was considered significant. HMTV sequences were detected in 15 (25%) samples of malignant breast tumors, and 8 (40%) samples of breast benign tumor. There was no statistical significant association between the detection of env sequences of HMTV and age, grade, hormone receptors, EGFR, or DAXX expression when compared to clinicopathological characteristics. However, Statistically the data showed highly significant difference in the expression of EGFR between study groups, age , and histological types (for all p value = 0.0001), and negative significant association was observed between EGFR and both Her2 and TNBC. There was statistical significant difference between DAXX (+) and DAXX (−) in study groups as( P =0.002),and it significantly associated with age and histological types of breast cancer(P= 0.031,0.007 respectively). Statistically no significant association was found between DAXX and EGFR , grade, Her2.TNBC of breast cancer. The current study found HMTV env sequences in breast tumors of Iraqi women, suggesting that a larger sample size is needed to illustrate the likely causative role of HMTV in the development of human breast malignancy. Moreover, a negative associations was found between HMTV and both DAXX and EGFR expression. | ||
| کلیدواژه‌ها | ||
| Breast cancer؛ HMTV؛ EGFR؛ DAXX | ||
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آمار تعداد مشاهده مقاله: 26 |
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