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Haramipour, P, Hassanpour, Sh, Rezaei, A. (1401). Prenatal Exposure to L-Citrulline Has Positive Effects on Reflexive Motor Behavior in Newborn Mice. سامانه مدیریت نشریات علمی, 77(5), 1961-1970. doi: 10.22092/ari.2022.359827.2482
P Haramipour; Sh Hassanpour; A Rezaei. "Prenatal Exposure to L-Citrulline Has Positive Effects on Reflexive Motor Behavior in Newborn Mice". سامانه مدیریت نشریات علمی, 77, 5, 1401, 1961-1970. doi: 10.22092/ari.2022.359827.2482
Haramipour, P, Hassanpour, Sh, Rezaei, A. (1401). 'Prenatal Exposure to L-Citrulline Has Positive Effects on Reflexive Motor Behavior in Newborn Mice', سامانه مدیریت نشریات علمی, 77(5), pp. 1961-1970. doi: 10.22092/ari.2022.359827.2482
Haramipour, P, Hassanpour, Sh, Rezaei, A. Prenatal Exposure to L-Citrulline Has Positive Effects on Reflexive Motor Behavior in Newborn Mice. سامانه مدیریت نشریات علمی, 1401; 77(5): 1961-1970. doi: 10.22092/ari.2022.359827.2482

Prenatal Exposure to L-Citrulline Has Positive Effects on Reflexive Motor Behavior in Newborn Mice

Archives of Razi Institute
مقاله 56، دوره 77، شماره 5، آذر و دی 2022، صفحه 1961-1970    اصل مقاله (765.9 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359827.2482
نویسندگان
P Haramipour1؛ Sh Hassanpour* 2؛ A Rezaei1
1Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده
L-citrulline (L-cit) is a nonessential amino acid that interacts with the veracity of neurotransmitters in the brain and might have a positive effect on fetal growth. However, there is no information about the possible effect of L-cit on reflexive motor behavior. Thus, this study aimed to determine the effects of prenatal exposure to L-cit on reflexive motor behavior in mice offspring. Forty pregnant female mice were allocated into four groups. In the control group, mice received water, while in groups 2-4, female mice orally gavage with L-cit (25, 50, and 100 mg/kg) at 5, 8, 11, 14, and 17 days of gestation (GD). Following delivery, pups were selected, and reflexive motor behaviors were determined using ambulation, hind-limb foot angle, surface righting, hind-limb strength, grip strength, front limb suspension, and negative geotaxis tests. Also, serum Nitric oxide (NO), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GPx) were determined. Based on the findings, maternal exposure to L-cit improved ambulation score, hind-limb suspension score, grip strength, and front-limb suspension in offspring (P<0.05). Prenatal exposure to L-cit decreased surface righting, hind-limb foot angle, and negative geotaxis in offspring (P<0.05). L-cit decreased immobility time in forced swimming test (FST), tail suspension test (TST), and increased number of squares crossed in the open field test (OFT) and spending time on rotarod on postpartum mice (P<0.05). L-cit increased serum NO levels (P<0.05). L-cit decreased blood MDA and increased SOD and GPx levels in offspring (P<0.05). Findings revealed that L-cit improves postpartum behaviors in mice and reflexive motor in their pups.
کلیدواژه‌ها
L-Citrulline؛ Maternal exposure؛ Motor reflex؛ Mice
مراجع
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