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Kareem, R. A, Kadhim Baqer, L. (1402). Immunological Role of Toll-Like Receptor Markers (TLR2 and TLR4) in Patients with Helicobacter pylori infection at Basrah, Iraq. سامانه مدیریت نشریات علمی, 78(2), 601-609. doi: 10.22092/ari.2022.359715.2458
R. A Kareem; L Kadhim Baqer. "Immunological Role of Toll-Like Receptor Markers (TLR2 and TLR4) in Patients with Helicobacter pylori infection at Basrah, Iraq". سامانه مدیریت نشریات علمی, 78, 2, 1402, 601-609. doi: 10.22092/ari.2022.359715.2458
Kareem, R. A, Kadhim Baqer, L. (1402). 'Immunological Role of Toll-Like Receptor Markers (TLR2 and TLR4) in Patients with Helicobacter pylori infection at Basrah, Iraq', سامانه مدیریت نشریات علمی, 78(2), pp. 601-609. doi: 10.22092/ari.2022.359715.2458
Kareem, R. A, Kadhim Baqer, L. Immunological Role of Toll-Like Receptor Markers (TLR2 and TLR4) in Patients with Helicobacter pylori infection at Basrah, Iraq. سامانه مدیریت نشریات علمی, 1402; 78(2): 601-609. doi: 10.22092/ari.2022.359715.2458

Immunological Role of Toll-Like Receptor Markers (TLR2 and TLR4) in Patients with Helicobacter pylori infection at Basrah, Iraq

Archives of Razi Institute
مقاله 13، دوره 78، شماره 2، خرداد و تیر 2023، صفحه 601-609    اصل مقاله (538.41 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359715.2458
نویسندگان
R. A Kareem* ؛ L Kadhim Baqer
Department of Microbiology, College of Medicine, University of Basrah, Basrah, Iraq
چکیده
Helicobacter pylori is a spiral-shaped, flagellated, microaerophilic bacteria found in the human gastric sub-mucosa. This study aimed to investigate the association between toll-like receptor markers (TLR2 and TLR4) and the infection with Helicobacter pylori. The study involved 224 participants randomly divided into 2 equal groups (n=112). The patient group (n=112) was involved with several gastrointestinal symptoms. They were compared to a control group (n=112) with negative H. pylori tests. Patients and control were subjected to upper digestive endoscopy with gastric biopsy for the rapid urease test, rapid diagnostic test, and ELISA test for TLR2 and TLR4 detection. The recorded data showed that 36 (32.1 %) patients with H. pylori were in the second to the third decades of their life (25-34 years), while 22 (19.6 %) positive H. pylori-infected individuals were in the age range of 15-24 years, which were very close to the participants in the age range of 35-44 years. On the other hand, it is revealed that 15 (13.4%) participants were in the fourth to fifth decades of life. This rate was very similar to the groups of patients within the sixth to seventh decades of their life (13 (11.6 %)), but the lowest number of cases with H. pylori patients found in the age range of 55-64 years were recorded 7.1%. In conclusion, the concentration of TLR2 and TLR4 is higher in H. pylori-positive participants compared to the control group. This might reflect the response of innate immunity of the body to the presence of H. pylori infection, and thus it may be used as an ancillary tool in the detection of the patient's susceptibility to this type of infection.
کلیدواژه‌ها
H. pylori؛ TLR 2 and TLR4؛ Gastrointestinal tract
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مراجع
  1. Dang BN, Graham DY. Helicobacter pylori infection and antibiotic resistance: a WHO high priority? Nat Rev Gastroenterol Hepatol. 2017;14(7):383-4.
  2. Youssefi M, Tafaghodi M, Farsiani H, Ghazvini K, Keikha M. Helicobacter pylori infection and autoimmune diseases; Is there an association with systemic lupus erythematosus, rheumatoid arthritis, autoimmune atrophy gastritis and autoimmune pancreatitis? A systematic review and meta-analysis study. J Microbiol Immunol Infect. 2021;54(3):359-69.
  1. Baqir GK, Al-Sulami A, Hamadi SS. Relationship between ABO blood groups and Helicobacter pylori infection among patients with dyspepsia. J Virol Microbiol. 2016;2016:30-1.
  2. Ansari S, Yamaoka Y. Survival of Helicobacter pylori in gastric acidic territory. Helicobacter. 2017;22(4):e12386.
  3. Alatbee AH. High prevalence of helicobacter pylori in Basra city Southern of Iraq. J Phys Conf Ser. 2019:1279(1):012073.
  4. Savoldi A, Carrara E, Graham DY, Conti M, Tacconelli E. Prevalence of antibiotic resistance in Helicobacter pylori: a systematic review and meta-analysis in World Health Organization regions. Gastroenterology. 2018;155(5):1372-82. e17.
  5. Sabbagh P, Mohammadnia-Afrouzi M, Javanian M, Babazadeh A, Koppolu V, Vasigala VR, et al. Diagnostic methods for Helicobacter pylori infection: ideals, options, and limitations. Eur J Clin Microbiol Infect Dis. 2019;38(1):55-66.
  6. Kawai T-LR. Their Crosstalk with Other Innate Receptors in Infection and Immunity. Immunity.
  7. Smith SM. Role of Toll-like receptors in Helicobacter pylori infection and immunity. World J Gastrointest Pathophysiol. 2014;5(3):133.
  8. Wallet SM, Puri V, Gibson III FC. Linkage of infection to adverse systemic complications: periodontal disease, toll-like receptors, and other pattern recognition systems. Vaccines. 2018;6(2):21.
  9. Li P, He C-Y, Xu Q, Sun L-P, Ha M-W, Yuan Y. Effect of the− 2081G/A polymorphism of the TLR4 gene and its interaction with Helicobacter pylori infection on the risk of gastric cancer in Chinese individuals. Genet Test Mol Biomarkers. 2014;18(9):610-5.
  10. Ihan A, Pinchuk IV, Beswick EJ. Inflammation, Immunity, and Vaccines for H elicobacter pylori Infection. Helicobacter. 2012;17:16-21.
  11. Loganathan R, Nazeer M, Goda V, Devaraju P, Ali M, Karunakaran P, et al. Genetic variants of TLR4 and TLR9 are risk factors for chronic Helicobacter pylori infection in South Indian Tamils. Hum Immunol. 2017;78(2):216-20.
  12. Matysiak-Budnik T, Megraud F. Helicobacter pylori in eastern European countries: what is the current status? Gut. 1994;35(12):1683.
  13. Al-Saimary IE. Demographical study of H. pylori associated gastritis. 2011.
  14. McColl KE. Helicobacter pylori infection. N Engl J Med. 2010;362(17):1597-604.
  15. Bakir WA, Yaseen NY, Kadem TJ, Hasoon HA, Majeed AM, Bakir WA, et al. Determination of serum pepsinogen I and II level at high risk for stomach cancer. Iraqi J Biotechnol. 2013;12(2):75-81.
  16. Mahmoud SS, Gasmi FM, Solan YO, Al-Harbi FA, Al-Harbi SA, Hummadi TA, et al. Prevalence and predictors of gastritis among patients attending health care facilities in Jazan, KSA. Int J Preventive Public Health Sci. 2016;2(1):1-7.
  17. Uno K, Kato K, Atsumi T, Suzuki T, Yoshitake J, Morita H, et al. Toll-like receptor (TLR) 2 induced through TLR4 signaling initiated by Helicobacter pylori cooperatively amplifies iNOS induction in gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2007;293(5):G1004-G12.
  18. Zhang Y, Zhang Y. Pterostilbene, a novel natural plant conduct, inhibits high fat-induced atherosclerosis inflammation via NF-κB signaling pathway in Toll-like receptor 5 (TLR5) deficient mice. Biomed Pharmacother. 2016;81:345-55.
  19. Turvey SE, Broide DH. Innate immunity. Journal of Allergy and Clinical Immunology. 2010;125(2):S24-S32.
  20. Amieva MR, El–Omar EM. Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology. 2008;134(1):306-23.
  21. Pimentel-Nunes P, Libânio D, Marcos-Pinto R, Areia M, Leja M, Esposito G, et al. Management of epithelial precancerous conditions and lesions in the stomach (maps II): European Society of gastrointestinal endoscopy (ESGE), European Helicobacter and microbiota Study Group (EHMSG), European Society of pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019. Endoscopy. 2019;51(04):365-88.
  22. AlSaimary IE, AlDhaheri HN, Murtadha MA. Molecular Gene Expression of Toll-Like Receptors 4 & 10 in Cellular Subsets of Human Peripheral Blood among Patients with Prostatitis: Conventional, Real Time Pcr and DNA Sequencing Techniques. Int J Med Sci Clin Invent. 2020;7(11):5095-102.
  23. Smith SM, Moran AP, Duggan SP, Ahmed SE, Mohamed AS, Windle HJ, et al. Tribbles 3: a novel regulator of TLR2-mediated signaling in response to Helicobacter pylori lipopolysaccharide. J Immunol. 2011;186(4):2462-71.
  24. Ghatage S, Anurupa M, Aithal SS, Shubha D, Angadi N. A study on reasons for nonadherence to 99DOTS among HIV-tuberculosis coinfected patients in Davanagere district, Karnataka. Int J Med Sci Public Health. 2018;7(10):805-9.
  25. Maeda S, Akanuma M, Mitsuno Y, Hirata Y, Ogura K, Yoshida H, et al. Distinct mechanism of Helicobacter pylori-mediated NF-κB activation between gastric cancer cells and monocytic cells. J Biol Chem. 2001;276(48):44856-64.
  26. Mustafa RA, Jasim HA, Al-Salait SKA. Quantitative Determination of Serum Level of TLR4, TLR7 and TLR9 in Pediatric Acute Lymphoblastic Leukemia (ALL) Patients in Basrah, Iraq. Biomed Pharmacol J. 2021;14(4):2255-60.
  1. Bartova J, Sommerova P, Lyuya-Mi Y, Mysak J, Prochazkova J, Duskova J, et al. Periodontitis as a risk factor of atherosclerosis. J Immunol Res. 2014;2014.
  2. Elseweidy M. Brief review on the causes, diagnosis and therapeutic treatment of gastritis disease. Altern Integr Med. 2017;6(1):1-6.
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