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Mohammed Jasim, E, Khudhur Jameel, S, Ihsan Awadh, N. (1402). Estimation of Interleukin 32 and Interleukin 37 Serum Levels in Iraqi Patients with Rheumatoid Arthritis. سامانه مدیریت نشریات علمی, 78(2), 743-750. doi: 10.22092/ari.2022.359861.2489
E Mohammed Jasim; S Khudhur Jameel; N Ihsan Awadh. "Estimation of Interleukin 32 and Interleukin 37 Serum Levels in Iraqi Patients with Rheumatoid Arthritis". سامانه مدیریت نشریات علمی, 78, 2, 1402, 743-750. doi: 10.22092/ari.2022.359861.2489
Mohammed Jasim, E, Khudhur Jameel, S, Ihsan Awadh, N. (1402). 'Estimation of Interleukin 32 and Interleukin 37 Serum Levels in Iraqi Patients with Rheumatoid Arthritis', سامانه مدیریت نشریات علمی, 78(2), pp. 743-750. doi: 10.22092/ari.2022.359861.2489
Mohammed Jasim, E, Khudhur Jameel, S, Ihsan Awadh, N. Estimation of Interleukin 32 and Interleukin 37 Serum Levels in Iraqi Patients with Rheumatoid Arthritis. سامانه مدیریت نشریات علمی, 1402; 78(2): 743-750. doi: 10.22092/ari.2022.359861.2489

Estimation of Interleukin 32 and Interleukin 37 Serum Levels in Iraqi Patients with Rheumatoid Arthritis

Archives of Razi Institute
مقاله 31، دوره 78، شماره 2، خرداد و تیر 2023، صفحه 743-750    اصل مقاله (493.25 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359861.2489
نویسندگان
E Mohammed Jasim* 1؛ S Khudhur Jameel1؛ N Ihsan Awadh2
1Medical Microbiology Department, Medical College, Al-Iraqia University, Baghdad, Iraq
2Medical City Complex, Internal Medicine Department, Rheumatology Unit, Baghdad, Iraq
چکیده
Rheumatoid arthritis (RA) is an autoimmune condition characterized by persistent inflammation in synovial joints. Interleukine-32 (IL32) is known to have significant pro-inflammatory effects in RA, and IL37 is an anti-inflammatory cytokine that reduces the immune response and inflammation. This study aimed to investigate serum levels of IL32 and IL73 in RA patients. The sample included 50 patients (46 females and four males) with RA and 40 healthy controls. The enzyme-linked immunosorbent assay (ELISA) detected serum levels of IL32 and IL37. The disease parameters’ activity was measured by the clinical disease activity index, and the Erythrocyte sedimentation rate was measured by the Westergren method. Moreover, C-Reactive protein, Rheumatoid factor, and Anti-Cyclic Citrullinated Peptide antibodies were measured using the ELISA. The results showed elevated serum levels of IL32 and IL37 in patients with RA (P<0.05). The mean duration of RA in most patients was <12 years, and the level of disease activity among the cases group was mainly moderate (70%). There was no significant difference between the mean levels of IL32 and IL37 in patients with RA. This study showed that although IL32 and IL37 played an essential role in RA pathogenesis, there was no significant correlation between serum levels of IL32 and IL37 and disease duration or activity.
کلیدواژه‌ها
Cytokines؛ IL32؛ IL37؛ Pro-inflammatory cytokine؛ Rheumatoid arthritis
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مراجع
  1. Salama A, El-Ragehy N, Ali A, Elmahdy E. Role of interleukin-33 in patients with chronic hepatitis C in Menoufia University Hospitals, Egypt. 2017;30(1):249-54.
  2. Brennan FM, McInnes IB. Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest. 2008;118(11):3537-45.
  3. Alunno A, Carubbi F, Giacomelli R, Gerli R. Cytokines in the pathogenesis of rheumatoid arthritis: new players and therapeutic targets. BMC Rheumatol. 2017;1:3.
  4. Xu WD, Zhang M, Feng CC, Yang XK, Pan HF, Ye DQ. IL-32 with potential insights into rheumatoid arthritis. Clin Immunol. 2013;147(2):89-94.
  5. Dinarello CA. Introduction to the interleukin-1 family of cytokines and receptors: Drivers of innate inflammation and acquired immunity. Immunol Rev. 2018;281(1):5-7.
  6. Jia H, Liu J, Han B. Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases. Biomed Res Int. 2018;2018:3058640.
  7. Xia T, Zheng XF, Qian BH, Fang H, Wang JJ, Zhang LL, et al. Plasma Interleukin-37 Is Elevated in Patients with Rheumatoid Arthritis: Its Correlation with Disease Activity and Th1/Th2/Th17-Related Cytokines. Dis Markers. 2015;2015:795043.
  8. Singh H, Kumar H, Handa R, Talapatra P, Ray S, Gupta V. Use of clinical disease activity index score for assessment of disease activity in rheumatoid arthritis patients: an Indian experience. Arthritis. 2011;2011:146398.
  9. Favalli EG, Biggioggero M, Crotti C, Becciolini A, Raimondo MG, Meroni PL. Sex and Management of Rheumatoid Arthritis. Clin Rev Allergy Immunol. 2019;56(3):333-45.
  10. Al-Rubaye AF, Kadhim MJ, Hameed IH. Rheumatoid arthritis: history, stages, epidemiology, pathogenesis, diagnosis and treatment. Int J Toxicol Pharmacol Res. 2017;9(2):145-55.
  1. Alwan SA, Abdul-Ridha RA, Ali AI. Assessment of Plasma Level of CTHRC-I in Patients with Rheumatoid Arthritis. Iraqi J Med Sci. 2021;19(2).
  2. Ibrahem M. Siam MD, Nesreen S. Abd El-ghany, M.D., Monir AM. Gender Impact on Rheumatoid Arthritis Disease Characteristics in A Cohort of Egyptian Patients. Med J Cairo Univ. 2019;87(June):1895-9.
  3. Khadim NT, Al-Kazaz AKA. Single Nucleotide Polymorphism of Padi4 Gene )Rs11203367( in A Sample of Rheumatoid Arthritis Iraqi Patients. Iraqi J Sci. 2022;63(1):116-23.
  4. Gamal RM, Mahran SA, Abo El Fetoh N, Janbi F. Quality of life assessment in Egyptian rheumatoid arthritis patients: Relation to clinical features and disease activity. Egypt Rheumatol. 2016;38(2):65-70.
  5. Vazquez-Del Mercado M, Gomez-Banuelos E, Chavarria-Avila E, Cardona-Munoz E, Ramos-Becerra C, Alanis-Sanchez A, et al. Disease duration of rheumatoid arthritis is a predictor of vascular stiffness: a cross-sectional study in patients without known cardiovascular comorbidities: A STROBE-compliant article. Medicine (Baltimore). 2017;96(33):e7862.
  6. Salaffi F, Di Carlo M, Farah S, Marotto D, Atzeni F, Sarzi-Puttini P. Rheumatoid arthritis disease activity assessment in routine care: performance of the most widely used composite disease activity indices and patient-reported outcome measures. Acta Bio Medica: Atenei Parmensis. 2021;92(4).
  7. Gorial FI. Validity and reliability of CDAI in comparison to DAS28 in iraqi patients with active rheumatoid arthritis. J Fac Med Baghdad. 2012;54(3):231-3.
  8. Tishkowski K, Gupta V. Erythrocyte Sedimentation Rate. StatPearls: tatPearls Publishing; 2022.
  9. Subhi IM, Zgair AK, Al-Osami MH. Some immunological aspects of rheumatoid arthritis post treated with biological treatment (enbrel). J Pharm Sci Res. 2018;10(11):2934-7.
  10. Abd El-Aziz TA, Mohamed RH. Influence of MTHFR C677T gene polymorphism in the development of cardiovascular disease in Egyptian patients with rheumatoid arthritis. Gene. 2017;610:127-32.
  11. Sproston NR, Ashworth JJ. Role of C-Reactive Protein at Sites of Inflammation and Infection. Front Immunol. 2018;9:754.
  1. Ahmad R, Zgair A. Immunological and Biological Manifestation of Rheumatoid Arthritis Patient in Iraq. Indian J Med Forensic Med Toxicol. 2021;15(4):1344-50.
  2. Abdulrazzaq AA, Hadi TF. The Effect Of Prealbumin On Liver In Rheumatoid Arthritis In Iraqi Patients. Nveo-Nat Volatiles Essent Oils J. 2021:4671-80.
  3. van Delft MAM, Huizinga TWJ. An overview of autoantibodies in rheumatoid arthritis. J Autoimmun. 2020;110:102392.
  4. Al-Taee MM, Mohmood DI, Muhammed MM. Determining Levels of Rheumatoid Factor (RF) and C-reactive protein (CRP) in a Blood Sample of Iraqi Patients with Rheumatoid Arthritis (RA). Al-Nisour J Med Sci. 2019;1(1):133-9.
  5. Mohamed A, Abdellatif S, El-Noshokaty E. Serum level of 14-3-3η (Eta) protein as a diagnostic marker for rheumatoid arthritis and potential correlation with disease activity. MOJ Orthop Rheumatol. 2017;7(4):280.
  6. Damen M, Schraa K, Tweehuysen L, den Broeder AA, Netea MG, Popa CD, et al. Genetic variant in IL-32 is associated with the ex vivo cytokine production of anti-TNF treated PBMCs from rheumatoid arthritis patients. Sci Rep. 2018;8(1):14050.
  7. Gualberto Cardoso PR, Diniz Lopes Marques C, de Melo Vilar K, Dantas AT, Branco Pinto Duarte AL, Pitta IDR, et al. Interleukin-18 in Brazilian Rheumatoid Arthritis Patients: Can Leflunomide Reduce It? Autoimmune Dis. 2021;2021:6672987.
  1. Joosten LA, Netea MG, Kim SH, Yoon DY, Oppers-Walgreen B, Radstake TR, et al. IL-32, a proinflammatory cytokine in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2006;103(9):3298-303.
  2. Gui M, Zhang H, Zhong K, Li Y, Sun J, Wang L. Clinical significance of interleukin-32 expression in patients with rheumatoid arthritis. Asian Pac J Allergy Immunol. 2013;31(1):73-8.
  3. Mohammad WJ, Ibrahim NAK, Obed SF, Jebur MS. Association of TNFRII polymorphisms and IL-37 in rheumatoid arthritis Iraqi patients. J. Port Sci Res. 2021;4(1):35-40.
  4. Ebrahiem SA, Falih EH, Mahdi HAM, Shaban AH. Indoor 222Rn measurement and hazards indices in houses of Al-Najaf province – Iraq. AIP Conference Proceedings. 2018;1968(1).
  5. Cao S, Shi H, Sun G, Chen Y, Hou G, Wang D, et al. Serum IL-37 Level Is Associated with Rheumatoid Arthritis and Disease Activity: A Meta-Analysis. Biomed Res Int. 2021;2021:6653439.
  6. Baraka EA, Balata MG, Ahmed SH, Khamis AF, Elattar EA. Interleukin-37 as an anti-inflammatory cytokine: does its relation to disease activity suggest its potential role in rheumatoid arthritis therapy? Egypt Rheumatol Rehabil. 2021;48(1):1-9.
  7. Wells AF, Curtis JR, Betts KA, Douglas K, Du EX, Ganguli A. Systematic Literature Review and Meta-analysis of Tumor Necrosis Factor-Alpha Experienced Rheumatoid Arthritis. Clin Ther. 2017;39(8):1680-94 e2.
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