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Fazlelahi, Z, Kaboutari, J, Zendehdel, M, Panahi, N. (1402). Effects of Intracerebroventricular Injection of the Steroidal and Non-Steroidal Anti-Inflammatory Drugs on the Seizures during the Estrous Cycle in Rat. سامانه مدیریت نشریات علمی, 78(3), 807-813. doi: 10.22092/ari.2022.360115.2553
Z Fazlelahi; J Kaboutari; M Zendehdel; N Panahi. "Effects of Intracerebroventricular Injection of the Steroidal and Non-Steroidal Anti-Inflammatory Drugs on the Seizures during the Estrous Cycle in Rat". سامانه مدیریت نشریات علمی, 78, 3, 1402, 807-813. doi: 10.22092/ari.2022.360115.2553
Fazlelahi, Z, Kaboutari, J, Zendehdel, M, Panahi, N. (1402). 'Effects of Intracerebroventricular Injection of the Steroidal and Non-Steroidal Anti-Inflammatory Drugs on the Seizures during the Estrous Cycle in Rat', سامانه مدیریت نشریات علمی, 78(3), pp. 807-813. doi: 10.22092/ari.2022.360115.2553
Fazlelahi, Z, Kaboutari, J, Zendehdel, M, Panahi, N. Effects of Intracerebroventricular Injection of the Steroidal and Non-Steroidal Anti-Inflammatory Drugs on the Seizures during the Estrous Cycle in Rat. سامانه مدیریت نشریات علمی, 1402; 78(3): 807-813. doi: 10.22092/ari.2022.360115.2553

Effects of Intracerebroventricular Injection of the Steroidal and Non-Steroidal Anti-Inflammatory Drugs on the Seizures during the Estrous Cycle in Rat

Archives of Razi Institute
مقاله 5، دوره 78، شماره 3، مرداد و شهریور 2023، صفحه 807-813    اصل مقاله (474.37 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.360115.2553
نویسندگان
Z Fazlelahi1؛ J Kaboutari* 2؛ M Zendehdel3؛ N Panahi1
1Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Basic Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
3Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran
چکیده
Because of the mutual relationship between neural inflammation and seizure, this study aimed to determine the effects of intracerebroventricular (ICV) injection of the steroidal and non-steroidal anti-inflammatory drugs on pentylenetetrazol (PTZ)-induced seizures during the estrous cycle in rats. A total of 105 adult female Wistar rats were selected and divided into seven groups, including the control (saline), ketorolac tris salt (7.5, 15, and 30 µg), and methylprednisolone acetate (0.15, 0.3, and 0.6 µg), each with four subgroups (proestrus, estrus, metestrus, and diestrus) and three replicates (n=5). After a week of acclimatization, the estrous phase determination and synchronization were performed. Acute epilepsy was inspired by the intraperitoneal injection of 80 mg/kg of PTZ 30 min after the ICV injection of ketorolac and methylprednisolone acetate. The initiation time of myoclonic seizures (ITMS), the initiation time of tonic-clonic seizures (ITTS), seizure duration (SD), and mortality rate (MR) were measured for 30 min. Data were shown as mean±SD and analyzed using One-way ANOVA followed by Tukey–Kramer multiple comparison post hoc test (P<0.05). According to the results, ketorolac (15 and 30 µg) and methylprednisolone acetate (0.3 and 0.6 µg) significantly increased the ITTS and ITMS but decreased SD during the estrous cycle, compared to the control (P<0.05). Moreover, MR and SD were significantly decreased by ketorolac (7.5, 15, and 30 µg) and methylprednisolone (0.3 and 0.6 µg), compared to the control during the estrous cycle (P<0.05). Therefore, it seems that both ketorolac and methylprednisolone possess dose-dependent anticonvulsant effects that may decrease neural inflammation.
کلیدواژه‌ها
Intracerebroventricular؛ Methylprednisolone acetate؛ Ketorolac tris salt؛ Rat؛ Seizure
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مراجع
  1. Kumar D, Iltaf Sr S, Umer A, Fatima M, Zaheer M, Waqar K, et al. The frequency of catamenial epilepsy in female epileptic patients of reproductive age group presented to the tertiary care hospital. Cureus. 2020;12(11).
  1. Veliskova J, Desantis KA. Sex and hormonal influences on seizures and epilepsy. Horm Behav. 2013;63(2):267-77.
  2. Frank S, Tyson NA. A Clinical Approach to Catamenial Epilepsy: A Review. Perm J. 2020;24:1-3.
  3. Guille C, Spencer S, Cavus I, Epperson CN. The role of sex steroids in catamenial epilepsy and premenstrual dysphoric disorder: implications for diagnosis and treatment. Epilepsy Behav. 2008;13(1):12-24.
  4. Radu BM, Epureanu FB, Radu M, Fabene PF, Bertini G. Nonsteroidal anti-inflammatory drugs in clinical and experimental epilepsy. Epilepsy Res. 2017;131:15-27.
  5. Vicatos AI, Caira MR. Cyclodextrin complexes of the anticonvulsant agent valproic acid. CrystEngComm. 2021;23(37):6582-90.
  6. Guvenir H, Dibek Misirlioglu E, Civelek E, Toyran M, Buyuktiryaki B, Ginis T, et al. The Frequency and Clinical Features of Hypersensitivity Reactions to Antiepileptic Drugs in Children: A Prospective Study. J Allergy Clin Immunol Pract. 2018;6(6):2043-50.
  7. Yoshino T, Noguchi M, Okutsu H, Kimoto A, Sasamata M, Miyata K. Celecoxib does not induce convulsions nor does it affect GABAA receptor binding activity in the presence of new quinolones in mice. Eur J Pharmacol. 2005;507(1-3):69-76.
  8. Mattson RH, Cramer JA. Epilepsy, sex hormones, and antiepileptic drugs. Epilepsia. 1985;26(1):40-51.
  9. van Luijtelaar G, Budziszewska B, Jaworska-Feil L, Ellis J, Coenen A, Lason W. The ovarian hormones and absence epilepsy: a long-term EEG study and pharmacological effects in a genetic absence epilepsy model. Epilepsy Res. 2001;46(3):225-39.
  1. Kaboutari J, Zendehdel M, Habibian S, Azimi M, Shaker M, Karimi B. The antiepileptic effect of sodium valproate during different phases of the estrous cycle in PTZ-induced seizures in rats. J Physiol Biochem. 2012;68(2):155-61.
  2. Zanboori A, Tamaddonfard E, Mojtahedin A. The effect of intracerebroventricular injection of histamine in visceral nociception induced by acetic acid in rats. Indian J Pharmacol. 2010;42(5):289-92.
  3. Godfrey KEM, Gardner AC, Kwon S, Chea W, Muthukumaraswamy SD. Differences in excitatory and inhibitory neurotransmitter levels between depressed patients and healthy controls: A systematic review and meta-analysis. J Psychiatr Res. 2018;105:33-44.
  4. Clossen BL, Reddy DS. Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy. Biochim Biophys Acta Mol Basis Dis. 2017;1863(6):1519-38.
  5. Gunn BG, Baram TZ. Stress and Seizures: Space, Time and Hippocampal Circuits. Trends Neurosci. 2017;40(11):667-79.
  6. Voinescu PE. Catamenial Epilepsy. In: O’Neal MA, editor. Neurology and Psychiatry of Women: A Guide to Gender-based Issues in Evaluation, Diagnosis, and Treatment. Cham: Springer International Publishing; 2019. p. 85-94.
  7. Reddy DS, Carver CM, Clossen B, Wu X. Extrasynaptic gamma-aminobutyric acid type A receptor-mediated sex differences in the antiseizure activity of neurosteroids in status epilepticus and complex partial seizures. Epilepsia. 2019;60(4):730-43.
  8. Van Meervenne SA, Volk HA, Matiasek K, Van Ham LM. The influence of sex hormones on seizures in dogs and humans. Vet J. 2014;201(1):15-20.
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