اخبار و اعلانات

 آمار

تعداد نشریات286
تعداد نشریات سازمان84
تعداد شماره‌ها2,944
تعداد مقالات33,229
تعداد مشاهده مقاله43,866,115
تعداد دریافت فایل اصل مقاله20,372,363
Ayob Alsaiegh, O. M, Lateef Husein, A, Harith Mohammad, M, Dhafer Abdulnafa, Z. (1402). Evaluation of the Coenzyme Q10 and Some Biochemical Parameters in Patients with Ischemic Heart Disease. سامانه مدیریت نشریات علمی, 78(3), 853-861. doi: 10.22092/ari.2022.359889.2500
O. M Ayob Alsaiegh; A Lateef Husein; M Harith Mohammad; Z Dhafer Abdulnafa. "Evaluation of the Coenzyme Q10 and Some Biochemical Parameters in Patients with Ischemic Heart Disease". سامانه مدیریت نشریات علمی, 78, 3, 1402, 853-861. doi: 10.22092/ari.2022.359889.2500
Ayob Alsaiegh, O. M, Lateef Husein, A, Harith Mohammad, M, Dhafer Abdulnafa, Z. (1402). 'Evaluation of the Coenzyme Q10 and Some Biochemical Parameters in Patients with Ischemic Heart Disease', سامانه مدیریت نشریات علمی, 78(3), pp. 853-861. doi: 10.22092/ari.2022.359889.2500
Ayob Alsaiegh, O. M, Lateef Husein, A, Harith Mohammad, M, Dhafer Abdulnafa, Z. Evaluation of the Coenzyme Q10 and Some Biochemical Parameters in Patients with Ischemic Heart Disease. سامانه مدیریت نشریات علمی, 1402; 78(3): 853-861. doi: 10.22092/ari.2022.359889.2500

Evaluation of the Coenzyme Q10 and Some Biochemical Parameters in Patients with Ischemic Heart Disease

Archives of Razi Institute
مقاله 10، دوره 78، شماره 3، مرداد و شهریور 2023، صفحه 853-861    اصل مقاله (502.36 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359889.2500
نویسندگان
O. M Ayob Alsaiegh* 1؛ A Lateef Husein1؛ M Harith Mohammad2؛ Z Dhafer Abdulnafa2
1Department of Biochemistry, College of Medicine University of Tikrit, Tikrit, Iraq
2College of Medicine, University of Mosul, Mosul, Iraq
چکیده
Ischemic heart disease (IHD) is a common diagnosis and a leading cause of death in both males and females. It accounts for 30% of deaths worldwide, including 40% in high-income countries and approximately 28% in developing nations. Several cardiac markers have been used to diagnose and manage cardiovascular diseases. The Coenzyme Q10 (CoQ10) plays a potential role in the prevention and treatment of cardiovascular diseases by improving cellular bioenergetics. This study aimed to evaluate the role of CoQ10 and other biochemical parameters in IHD (angina pectoris and myocardial infarction). A case-control study was conducted at the Intensive Care Unit of Ibn-Sina Teaching Hospital and Al-Salam General Hospital in Nineveh Province, Iraq, for two months, from April 1 to June 1, 2022. It included 90 adult participants divided into case and control groups. The case group included 60 patients admitted to the Intensive Care Unit and diagnosed with IHD (myocardial infarction or angina pectoris), and the control group included 30 healthy participants matched in age and gender with the case group. Subsequent assay of C-reactive protein (CRP), creatine phosphokinase (CPK), troponin level, and serum CoQ10. In this study, 81.7% of patients in the case group were diagnosed with myocardial infarction. Means of serum lactate dehydrogenase (LDH), CRP, CPK, and troponin were significantly higher, while those of CoQ10 were significantly lower in the case group, compared to the controls. Statistically, a significant moderate negative correlation was detected between CoQ10 level and age. Moreover, significant weak correlations were observed between CoQ10 level and all serum LDH, CRP, and troponin levels. Patients with IHDs had considerably low serum levels of CoQ10, compared to the control group. The highest mean value of lipid profile, except for triglyceride, was observed in patients with IHD, compared to the control group. This explains the role that cholesterol compounds play in the progression of IHD. No significant correlations were found between CoQ10 with body mass index and CPK. The CoQ10 had a negative correlation with age, serum LDH, CRP, and troponin.
کلیدواژه‌ها
Biomarkers؛ Cardiovascular diseases؛ Coenzyme Q10؛ Iraq؛ Ischemia
سایر فایل های مرتبط با مقاله
مراجع
  1. Wang H, Bhutta ZA, Coates MM, Coggeshall M, Dandona L, Diallo K, et al. Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1725-74.
  2. Kivimäki M, Nyberg ST, Batty GD, Fransson EI, Heikkilä K, Alfredsson L, et al. Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data. Lancet. 2012;380(9852):1491-7.
  3. Ayer A, Macdonald P, Stocker R. CoQ10 function and role in heart failure and ischemic heart disease. Annu Rev Nutr. 2015;35:175-213.
  4. Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, Vega AF, De La Mata M, Pavón AD, et al. Coenzyme q10 therapy. Mol Syndromol. 2014;5(3-4):187-97.
  5. Zozina VI, Covantev S, Goroshko OA, Krasnykh LM, Kukes VG. Coenzyme Q10 in Cardiovascular and Metabolic Diseases: Current State of the Problem. Curr Cardiol Rev. 2018;14(3):164-74.
  6. Khandelwal V, Kapoor A, Kazmi D, Sinha A, Kashyap S, Khanna R, et al. Exploring the association of fibrinogen and CRP with the clinical spectrum of CAD and periprocedural outcomes in patients undergoing percutaneous coronary interventions. Ann Card Anaesth. 2022;25(1):34-40.
  7. Bouzidi N, Messaoud MB, Maatouk F, Gamra H, Ferchichi S. Relationship between high sensitivity C-reactive protein and angiographic severity of coronary artery disease. J Geriatr Cardiol. 2020;17(5):256-63.
  8. Shahid SU, Sarwar S. The abnormal lipid profile in obesity and coronary heart disease (CHD) in Pakistani subjects. Lipids in health and disease. 2020;19(1):1-7.
  9. Petrie JR, Guzik TJ, Touyz RM. Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms. Can J Cardiol. 2018;34(5):575-84.
  10. Shimizu M, Miyazaki T, Takagi A, Sugita Y, Ouchi S, Aikawa T, et al. Low coenzyme Q10 levels in patients with acute cardiovascular disease are associated with long-term mortality. Heart Vessels. 2021;36(3):401-7.
  11. Yalcin A, Kilinc E, Sagcan A, Kultursay H. Coenzyme Q10 concentrations in coronary artery disease. Clin Biochem. 2004;37(8):706-9.
  12. Potgieter M, Pretorius E, Pepper MS. Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation. Nutr Rev. 2013;71(3):180-8.
  13. Kumar A, Kaur H, Devi P, Mohan V. Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome. Pharmacol Ther. 2009;124(3):259-68.
  14. Bergamini C, Cicoira M, Rossi A, Vassanelli C. Oxidative stress and hyperuricaemia: pathophysiology, clinical relevance, and therapeutic implications in chronic heart failure. Eur J Heart Fail. 2009;11(5):444-52.
  15. Lim J-Y, Park SJ, Hwang H-Y, Park EJ, Nam JH, Kim J, et al. TGF-β1 induces cardiac hypertrophic responses via PKC-dependent ATF-2 activation. J Mol Cell Cardiol. 2005;39(4):627-36.
  16. Yang Y-K, Wang L-P, Chen L, Yao X-P, Yang K-Q, Gao L-G, et al. Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction. Clinica Chimica Acta. 2015;450:83-9.
  17. Swarnakar NK, Jain AK, Singh RP, Godugu C, Das M, Jain S. Oral bioavailability, therapeutic efficacy and reactive oxygen species scavenging properties of coenzyme Q10-loaded polymeric nanoparticles. Biomaterials. 2011;32(28):6860-74.
  18. Mirhashemi SM, Najafi V, Raygan F, Asemi Z. The effects of coenzyme Q10 supplementation on cardiometabolic markers in overweight type 2 diabetic patients with stable myocardial infarction: A randomized, double-blind, placebo-controlled trial. ARYA Atheroscler. 2016;12(4):158.
  19. Muthukumaran K, Leahy S, Harrison K, Sikorska M, Sandhu JK, Cohen J, et al. Orally delivered water soluble Coenzyme Q10 (Ubisol-Q10) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson’s disease. BMC Neurosci. 2014;15(1):1-11.
  1. Fumagalli S, Fattirolli F, Guarducci L, Cellai T, Baldasseroni S, Tarantini F, et al. Coenzyme Q10 terclatrate and creatine in chronic heart failure: a randomized, placebo-controlled, double-blind study. Clin Cardiol. 2011;34(4):211-7.
  2. Biradar MS. Lipid Profile Study in Patients Diagnosed with Acute Myocardial Infarction for First Time and Admitted in Tertiary Care Hospital Mysuru. J Assoc Physicians India. 2022;70(4):11-2.
  3. Thabet NI, Hassanin HA, Kamal YM. Study of High Density Lipoprotein Cholesterol among Patients with Acute Coronary Syndrome in Sohag University Hospital. J Cardiol Curr Res. 2015;2(5):00073.
آمار
تعداد مشاهده مقاله: 2,042
تعداد دریافت فایل اصل مقاله: 448


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب