Phytochemical Profiles and Antioxidant Activity of Iranian Melia azedarach L.

Kamali, Marzie; Valizadeh, Jafar; Shaterian, Hamid Reza; Mottaghipisheh, Javad

doi:10.22092/jmpb.2022.358593.1472

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	Phytochemical Profiles and Antioxidant Activity of Iranian Melia azedarach L.
Journal of Medicinal plants and By-product
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 24 آبان 1401 اصل مقاله (359.78 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22092/jmpb.2022.358593.1472
نویسندگان
Marzie Kamali ¹^{، 2}؛ Jafar Valizadeh³؛ Hamid Reza Shaterian¹؛ Javad Mottaghipisheh⁴
¹Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran
²Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
³Department of Biology, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran
⁴Center for Molecular Biosciences (CMBI), Institute of Pharmacy/Pharmacognosy, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria
چکیده
Melia azedarach L. (Meliaceae family) is traditionally consumed to treat rheumatic pains, astringent, skin diseases, and diuretics. The present study aims to investigate the chemical composition of the flowers essential oil, as well as in vitro antioxidant activities of the leaves and fruits extracts of M. azedarach by DPPH (2,2-diphenyl-1-picrylhydrazyl) and FRAP (ferric reducing antioxidant power) assays. The GC-MS analysis of the essential oil identified oxygenated sesquiterpenes (43.7%) as the major chemical class. The volatile oil was rich in trans-nerolidol (39.5%), 1,4-dimethoxybenzene (11.6%), 2-phenylacetaldehyde (9.1%), and phenyl ethyl alcohol (7%). The leaves ethanolic extracts (LEE) indicating the IC₅₀ values 149 ± 0.05 µg/mL and 20.31 ± 0.03 mmol of the FeSO₄/g of the extract exhibited the strongest radical scavenging activity assessed via DPPH and FRAP assays, respectively. The higher antioxidant activity of LEE was correlated with the higher total phenolic contents (42.86 ± 0.02 μg gallic acid/mg extract) compared to the fruits (26.8 ± 0.05 μg gallic acid/mg extract). To the best of our knowledge, this is the first report on the essential oil compositions and the antioxidant activity of this species collected from the southeast ofIran. This study highlights that the M. azedarach essential oil can be a rich natural source of trans-nerolidol with diverse biological activities. Additionally, the ethanolic extract of leaves has significant antioxidant activities. Therefore, these findings might direct further complementary phytochemical and biological investigations of this species.
کلیدواژه‌ها
Antioxidant activity؛ Essential oil؛ Melia azedarach؛ Trans-nerolidol؛ Phytochemical profile

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Phytochemical Profiles and Antioxidant Activity of Iranian Melia azedarach L.