اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,038
تعداد مقالات33,991
تعداد مشاهده مقاله45,938,449
تعداد دریافت فایل اصل مقاله77,248,414
Kamali, Marzie, Valizadeh, Jafar, Shaterian, Hamid Reza, Mottaghipisheh, Javad. (1401). Phytochemical Profiles and Antioxidant Activity of Iranian Melia azedarach L.. سامانه مدیریت نشریات علمی, 13(1), 51-56. doi: 10.22092/jmpb.2022.358593.1472
Marzie Kamali; Jafar Valizadeh; Hamid Reza Shaterian; Javad Mottaghipisheh. "Phytochemical Profiles and Antioxidant Activity of Iranian Melia azedarach L.". سامانه مدیریت نشریات علمی, 13, 1, 1401, 51-56. doi: 10.22092/jmpb.2022.358593.1472
Kamali, Marzie, Valizadeh, Jafar, Shaterian, Hamid Reza, Mottaghipisheh, Javad. (1401). 'Phytochemical Profiles and Antioxidant Activity of Iranian Melia azedarach L.', سامانه مدیریت نشریات علمی, 13(1), pp. 51-56. doi: 10.22092/jmpb.2022.358593.1472
Kamali, Marzie, Valizadeh, Jafar, Shaterian, Hamid Reza, Mottaghipisheh, Javad. Phytochemical Profiles and Antioxidant Activity of Iranian Melia azedarach L.. سامانه مدیریت نشریات علمی, 1401; 13(1): 51-56. doi: 10.22092/jmpb.2022.358593.1472

Phytochemical Profiles and Antioxidant Activity of Iranian Melia azedarach L.

Journal of Medicinal plants and By-products
دوره 13، شماره 1، خرداد 2024، صفحه 51-56    اصل مقاله (514.19 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22092/jmpb.2022.358593.1472
نویسندگان
Marzie Kamali* 1، 2؛ Jafar Valizadeh3؛ Hamid Reza Shaterian1؛ Javad Mottaghipisheh4
1Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran
2Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
3Department of Biology, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran
4Center for Molecular Biosciences (CMBI), Institute of Pharmacy/Pharmacognosy, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria
چکیده
Melia azedarach L. (Meliaceae family) is traditionally consumed to treat rheumatic pains, astringent, skin diseases, and diuretics. The present study aims to investigate the chemical composition of the flowers essential oil, as well as in vitro antioxidant activities of the leaves and fruits extracts of M. azedarach by DPPH (2,2-diphenyl-1-picrylhydrazyl) and FRAP (ferric reducing antioxidant power) assays. The GC-MS analysis of the essential oil identified oxygenated sesquiterpenes (43.7%) as the major chemical class. The volatile oil was rich in trans-nerolidol (39.5%), 1,4-dimethoxybenzene (11.6%), 2-phenylacetaldehyde (9.1%), and phenyl ethyl alcohol (7%). The leaves ethanolic extracts (LEE) indicating the IC50 values 149 ± 0.05 µg/mL and 20.31 ± 0.03 mmol of the FeSO4/g of the extract exhibited the strongest radical scavenging activity assessed via DPPH and FRAP assays, respectively. The higher antioxidant activity of LEE was correlated with the higher total phenolic contents (42.86 ± 0.02 μg gallic acid/mg extract) compared to the fruits (26.8 ± 0.05 μg gallic acid/mg extract). To the best of our knowledge, this is the first report on the essential oil compositions and the antioxidant activity of this species collected from the southeast ofIran. This study highlights that the M. azedarach essential oil can be a rich natural source of trans-nerolidol with diverse biological activities. Additionally, the ethanolic extract of leaves has significant antioxidant activities. Therefore, these findings might direct further complementary phytochemical and biological investigations of this species.
کلیدواژه‌ها
Antioxidant activity؛ Essential oil؛ Melia azedarach؛ Trans-nerolidol؛ Phytochemical profile
مراجع
  1. Dehsheikh A.B., Sourestani M.M., Dehsheikh P.B., Mottaghipisheh J., Vitalini S., Iriti M. Monoterpenes: Essential oil components with valuable features. Mini Rev Med Chem. 2020;20:958-974.
  2. Mottaghipisheh J., Maghsoudlou M.T., Valizadeh J., Arjomandi R. Antioxidant activity and chemical composition of the essential oil of Ducrosia anethifolia (DC.) Boiss. from Neyriz. J Medicinal Plants by- Products. 2014;3:215-218.
  3. Mottaghipisheh J., Kiss T., Tóth B., Csupor D. The Prangos genus: a comprehensive review on traditional use, phytochemistry, and pharmacological activities. Phytochem Rev. 2020;19:1449-1470.
  4. Moon J-K., Shibamoto T. Antioxidant assays for plant and food components. J Agric Food Chem. 2009;57:1655-1666.
  5. Krishnaiah D., Sarbatly R., Nithyanandam R. A review of the antioxidant potential of medicinal plant species. Chem Eng Res Des. 2011;89:217-233.
  6. Kasote D.M., Katyare S.S., Hegde M.V., Bae H. Significance of antioxidant potential of plants and its relevance to therapeutic applications. Int J Biol Sci. 2015;11:982-991.
  7. Orhan I.E., Guner E., Ozturk N., Senol F., Erdem S.A., Kartal M., Sener B. Enzyme inhibitory and antioxidant activity of Melia azedarach L. naturalized in Anatolia and its phenolic acid and fatty acid composition. Ind Crops Prod. 2012;37:213-218.
  8. Oelrichs P.B., Hill M.W., Vallely P.J., MacLeod J.K., Molinski T.F. Toxic tetranortriterpenes of the fruit of Melia azedarach. Phytochemistry. 1983;22:531-534.
  9. Khan M.F., Rawat A.K., Pawar B., Gautam S., Srivastava A.K., Negi D.S. Bioactivity-guided chemical analysis of Melia azedarach L.(Meliaceae), displaying antidiabetic activity. Fitoterapia. 2014;98:98-103.
  10. Adams R.P. Identification of essential oil components by gas chromatography/mass spectrometry. Allured Publishing Corporation. 2007.
  11. Van Den Dool H., Kratz P.D. A generalization of the retention index system including linear temperature programmed gas-liquid partition chromatography. J Chromatogr A. 1963;11:463-471.
  12. Blois M.S. Antioxidant determinations by the use of a stable free radical. Nature. 1958;181:1199-1200.
  13. Benzie I.F., Strain J.J. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem. 1996;239:70-6.
  14. Kahkonen M., Hopia A., Vuorela H., Rauha J., Pihlaja K. Kujala TSl, Antioxidant activity of plant extracts containing phenolic compounds. J Agric Food Chem.1999;47:3954–3962.
  15. Nickavar B., Esbati N. Evaluation of the antioxidant capacity and phenolic content of three Thymus species. J Acupunct Meridian Stud. 2012;5:119-125.
  16. Safaei-Ghomi J., Ahmadi T., Batooli H. GC-MS identification of essential oil components and in vitro investigation of antioxidant activity of methanol extracts from flower and fruit fractions of Melia azedarach cultivated in central Iran. Chem Nat Compd. 2010;46:816-818.
  17. Kharkwal G., Pande C., Tewari G., Panwar A., Pande V. Volatile terpenoid composition and antimicrobial activity of flowers of Melia azedarach Linn. from north west Himalayas, India. J Indian Chem Soc. 2015;92:141-145.
  18. Piri E., Mahmoodi Sourestani M., Khaleghi E., Mottaghipisheh J., Zomborszki Z.P., Hohmann J., Csupor D. Chemo-diversity and antiradical potential of twelve Matricaria chamomilla L. populations from Iran: proof of ecological effects. Molecules. 2019;24:1315.
  19. Lau K-M., Su W-S., Chien S-C., Wang S-Y., Senthil Kumar K. Melia azedarach flowers and their volatile components improved human physiological and psychological functions. J Essent Oil-Bear Plants. 2021;24:1200-1211.
  20. Nahak G., Sahu R.K. In vitro antioxidative acitivity of Azadirachta indica and Melia azedarach Leaves by DPPH scavenging assay. Nat Sci. 2010;8:22-28.
  21. Marimuthu S., Balakrishnan P., Nair S. Phytochemical investigation and radical scavenging activities of Melia azedarach and its DNA protective effect in cultured lymphocytes. Pharm Biol. 2013;51:1331-1340.
  22. Njanje I., Bagla V.P., Beseni B.K., Mbazima V., Lebogo K.W., Mampuru L., Mokgotho M.P. Defatting of acetone leaf extract of Acacia karroo (Hayne) enhances its hypoglycaemic potential. BMC Complement Altern Med. 2017;17:482.
  23. Ervina M., Poerwono H., Widyowati R., Matsunami K. Sukardiman. Bio-selective hormonal breast cancer cytotoxic and antioxidant potencies of Melia azedarach L. wild type leaves. Biotechnol Rep. 2020;25:e00437.
  24. Afkhami-Ardekani O., Esmailidehaj M., Afkhami-Ardekani M., Esmaeili H., Afkhami-Ardekani A. Melia azedarach L. fruit extract effect on plasma lipid profile and cardiac and hepatic functions of diabetic rats. Iran j diabetes obes. 2017;9:155-163.
  25. Laughton M.J., Halliwell B., Evans P.J., Robin J., Hoult S. Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin: effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA. Biochem Pharmacol. 1989;38:2859-2865.
آمار
تعداد مشاهده مقاله: 518
تعداد دریافت فایل اصل مقاله: 910


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب