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Mahde, B. W, Abbas Hussein, A, Sahib, A. S. (1402). Preparation and in vitro Evaluation of Rasagiline Mesylate Hybrid Nanoparticles. سامانه مدیریت نشریات علمی, 78(3), 1023-1028. doi: 10.22092/ari.2022.360193.2563
B. W Mahde; A Abbas Hussein; A. S Sahib. "Preparation and in vitro Evaluation of Rasagiline Mesylate Hybrid Nanoparticles". سامانه مدیریت نشریات علمی, 78, 3, 1402, 1023-1028. doi: 10.22092/ari.2022.360193.2563
Mahde, B. W, Abbas Hussein, A, Sahib, A. S. (1402). 'Preparation and in vitro Evaluation of Rasagiline Mesylate Hybrid Nanoparticles', سامانه مدیریت نشریات علمی, 78(3), pp. 1023-1028. doi: 10.22092/ari.2022.360193.2563
Mahde, B. W, Abbas Hussein, A, Sahib, A. S. Preparation and in vitro Evaluation of Rasagiline Mesylate Hybrid Nanoparticles. سامانه مدیریت نشریات علمی, 1402; 78(3): 1023-1028. doi: 10.22092/ari.2022.360193.2563

Preparation and in vitro Evaluation of Rasagiline Mesylate Hybrid Nanoparticles

Archives of Razi Institute
مقاله 30، دوره 78، شماره 3، مرداد و شهریور 2023، صفحه 1023-1028    اصل مقاله (523.67 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.360193.2563
نویسندگان
B. W Mahde* 1، 2؛ A Abbas Hussein3؛ A. S Sahib4
1College of Pharmacy, University of Al-Qadisiyah, Al-Qadisiyah, Iraq
2College of Pharmacy, University of Baghdad, Baghdad, Iraq
3Baghdad College of Medical Sciences, Baghdad, Iraq
4Al-Mustaqbal University College, Babylon, Iraq
چکیده
Rasagiline is a selective and irreversible inhibitor of monoamine oxidase B (MAO-B) that is effective in the treatment of Parkinson’s disease (PD). It had antioxidant and anti-apoptotic activity in experimental models. Moreover, it has low permeability and its oral bioavailability is weak and highly variable due to extensive first-pass hepatic metabolism (35%). This study aimed to formulate rasagiline mesylate (RM) as a lipid-polymer hybrid nanoparticle in order to enhance its permeation and increase its chance to be absorbed by lymphatic circulation to avoid metabolism and control its release. Successful formulation (PCL-2) was reached by the nanoprecipitation method using polycaprolactone with RM in the organic phase and lecithin in the aqueous phase DSPE-PEG. The lipid:polymer ratio of 24% and DSPE: lecithin of 50% resulted in stable nanoparticles having a particle size of 132±4.58 nm, polydispersity index of 0.273±0.02, zeta potential of -25.6±3.3, entrapment efficiency of 46±3.9%, and drug loading of 51.93±6.5. Results showed that the diffusion was more effective on the release profile than the degradation and resulted in a Fickian diffusion mechanism.
کلیدواژه‌ها
Nanoparticles؛ Parkinson's disease؛ Propargylamine؛ Rasagiline
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مراجع
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