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Evaluation of IL-6, IL-25 & IL-35 in the COVID 19 Patients and their Correlation to DemographyData in the Symptomatic Patients | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 05 آذر 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.360087.2547 | ||
| نویسندگان | ||
Laith F. Mohammed H. Al-mquter  1؛ Saad Abdul Azeez Atiayh2
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| 1Microbiology department, College of Medicine, University of Thi-Qar, Iraq | ||
| 2Microbiology department, Cancer res. Unit, College of Medicine, University of Thi-Qar, Iraq | ||
| چکیده | ||
| The severe acute respiratory syndrome corona virus 2, also known as SARS-CoV-2, was first discovered in Wuhan, which is located in the province of Hubei in China. Cytokines play important role in the course of COVID 19 infections through their inflammatory or anti-inflammatory activities. This study was designed to detect the diagnostic value and relationships between the interleukins under this study, in addition to their relationships of demographic data in patients suffering from COVID 19. Patients with a confirmed diagnosis of COVID-19 based on laboratory (PCR) and the control healthy group were each given their own section of this investigation. The patient group had a total of 120 patients, including 62 men and 58 females, while the control group consisted of just 32 individuals (22 males and 10 females). Subdivision was then performed according to vaccinations, chronic diseases, gender, and residence. Cytokines levels were detected by using ELISA technique. The immunological status of COVID 19 patients was determined by measuring interleukin 6 (IL-6), interleukin 25 (IL-25), and interleukin 35 (IL-35). During the research, it was found that interleukin-6 was highly significant for patients with COVID 19 (0.001), and when compared with patients with chronic diseases it was not significant (0. 376) as well with residence (0.353) and gender (0.574), but it was significant with patients vaccinated with the corona vaccine(0.029), it was also found to be highly significant with IL- 25 &IL- 35. (.000). As for interleukin 25, it was highly significant for patients with COVID 19 (.007),and when compared with patients with chronic diseases it was significant (0. 049).While with residence ( 0.421) and gender (0.681) was no significant , but it was significant with patients vaccinated with the corona vaccine ( 0.047), it was also found to be highly significant with IL- 25 & IL- 35.( .000). As for interleukin 35, it was significant for patients with COVID 19 (0.013), and when compared with patients with chronic diseases I no significant (0. 344) as well with residence (0.877) and gender (0.880), but it was significant with patients vaccinated with the corona vaccine (0. 048). | ||
| کلیدواژه‌ها | ||
| SARS-CoV-2؛ Cytokines؛ Interleukins | ||
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آمار تعداد مشاهده مقاله: 72 |
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