اخبار و اعلانات

 آمار

تعداد نشریات286
تعداد نشریات سازمان84
تعداد شماره‌ها3,015
تعداد مقالات33,700
تعداد مشاهده مقاله44,906,754
تعداد دریافت فایل اصل مقاله44,027,343
Al-Rubaye, D. S, Mohammed Hamza, H, Ahmed Al-Khafaji, Q. (1402). Interleukin 17 and Growth Differentiation Factor 9 Influence in a Sample of Iraqi Infertile Males. سامانه مدیریت نشریات علمی, 78(3), 1147-1151. doi: 10.22092/ari.2022.359893.2503
D. S Al-Rubaye; H Mohammed Hamza; Q Ahmed Al-Khafaji. "Interleukin 17 and Growth Differentiation Factor 9 Influence in a Sample of Iraqi Infertile Males". سامانه مدیریت نشریات علمی, 78, 3, 1402, 1147-1151. doi: 10.22092/ari.2022.359893.2503
Al-Rubaye, D. S, Mohammed Hamza, H, Ahmed Al-Khafaji, Q. (1402). 'Interleukin 17 and Growth Differentiation Factor 9 Influence in a Sample of Iraqi Infertile Males', سامانه مدیریت نشریات علمی, 78(3), pp. 1147-1151. doi: 10.22092/ari.2022.359893.2503
Al-Rubaye, D. S, Mohammed Hamza, H, Ahmed Al-Khafaji, Q. Interleukin 17 and Growth Differentiation Factor 9 Influence in a Sample of Iraqi Infertile Males. سامانه مدیریت نشریات علمی, 1402; 78(3): 1147-1151. doi: 10.22092/ari.2022.359893.2503

Interleukin 17 and Growth Differentiation Factor 9 Influence in a Sample of Iraqi Infertile Males

Archives of Razi Institute
مقاله 45، دوره 78، شماره 3، مرداد و شهریور 2023، صفحه 1147-1151    اصل مقاله (561.82 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359893.2503
نویسندگان
D. S Al-Rubaye* 1؛ H Mohammed Hamza1؛ Q Ahmed Al-Khafaji2
1Department of Biotechnology, College of Science, Baghdad University, Baghdad, Iraq
2Consultant Immunologist, Iraqi Ministry of Health, Baghdad, Iraq
چکیده
Infertility is defined as the inability of couples to conceive after 1 year of regular unprotected intercourse, which affects 10-15% of couples. The present study aimed to investigate the influence of Interleukin-17 (IL-17) and growth differentiation factor 9 (GDF9) on three groups of infertile males, including control, azoospermia, and oligozoospermia. In total, this study was performed on 93 participants, consisting of 18, 65, and 10 subjects in the Azoospermia, oligozoospermia, and control groups, respectively. The mean plasma levels of IL-17 in the azoospermia and oligozoospermia groups were 21.317±3.605 and 15.101±2.416 ng/l, respectively, which were significantly higher than that in the control group (5.392±1.731 ng/l). Furthermore, the mean plasma levels of GDF9 in the azoospermia and oligozoospermia groups were 3.299±1.051 and 6.2603±2.621 ng/l, respectively, which was significantly higher than that in the control group (12.807±2.170 ng/l). One-way analysis of variance and least significant difference post-hoc test were performed to assess significant differences among means. R-squared measures how well the linear regression model fits the data. It can be interpreted as the proportion of variance of the outcome Y explained by the linear regression model. R-squared is a number between 0 and 1. In non-obstructive forms of severe oligozoospermia and azoospermia, like the case in the current study, intracytoplasmic sperm injection is suggested by using testicular biopsy for spermatozoa extraction, if viable spermatozoa are present.
کلیدواژه‌ها
Interleukin 17؛ Growth؛ Factor 9؛ Infertile males
سایر فایل های مرتبط با مقاله
مراجع
  1. Tosi F, Bonora E, Moghetti P. Insulin resistance in a large cohort of women with polycystic ovary syndrome: a comparison between euglycaemic-hyperinsulinaemic clamp and surrogate indexes. Hum Reprod. 2017;32(12):2515-21.
  2. Zegers-Hochschild F, Adamson GD, Dyer S, Racowsky C, De Mouzon J, Sokol R, et al. The international glossary on infertility and fertility care. Hum Reprod. 2017;32(9):1786-801.
  3. Briceag I, Costache A, Purcarea V, Cergan R, Dumitru M, Sajin M, et al. Fallopian tubes–literature review of anatomy and etiology in female infertility. J Med Life. 2015;8(2):129.
  4. Kumar N, Singh AK. Trends of male factor infertility, an important cause of infertility: A review of literature. J Hum Reprod Sci. 2015;8(4):191.
  5. Wahyuni S, Gholib G, Adnyane I, Agil M, Hamny H, Agungpriyono S, et al. Characterization of Seminiferous Epithelium Stages in the Wild Javan Muntjac (Muntiacus muntjak muntjak) Using the Tubular Morphology Method. Vet Med Int. 2018;2018.
  1. Duca Y, Calogero AE, Cannarella R, Condorelli RA, La Vignera S. Current and emerging medical therapeutic agents for idiopathic male infertility. Expert Opin Pharmacother. 2019;20(1):55-67.
  2. Loveland KL, Klein B, Pueschl D, Indumathy S, Bergmann M, Loveland BE, et al. Cytokines in male fertility and reproductive pathologies: immunoregulation and beyond. Front Endocrinol. 2017;8:307.
  3. Mary AP, Nandeesha H, Papa D, Chitra T, Ganesh RN, Menon V. Matrix metalloproteinase-9 is elevated and related to interleukin-17 and psychological stress in male infertility: A cross-sectional study. Int J Reprod Biomed. 2021;19(4):333.
  4. Guo QY, Gao ZZ, Zhao L, He JP, Dong CS. Expression of growth differentiation factor 9 (GDF9), ALK5, and claudin-11 in adult alpaca testis. Acta Histochem. 2013;115(1):16-21.
  5. Gnessi L, Scarselli F, Minasi MG, Mariani S, Lubrano C, Basciani S, et al. Testicular histopathology, semen analysis and FSH, predictive value of sperm retrieval: supportive counseling in case of reoperation after testicular sperm extraction (TESE). BMC Urol. 2018;18(1):1-8.
  6. Alamiri W. Evaluation of seminal plasma interleukin 17 in infertile males. Human Andrology. 2021;11(11):1-5.
  7. Nicholls PK, Harrison CA, Gilchrist RB, Farnworth PG, Stanton PG. Growth differentiation factor 9 is a germ cell regulator of Sertoli cell function. Endocrinology. 2009;150(5):2481-90.
  8. Jungwirth A, Giwercman A, Tournaye H, Diemer T, Kopa Z, Dohle G, et al. European Association of Urology guidelines on Male Infertility: the 2012 update. Eur Urol. 2012;62(2):324-32.
  9. Esteves SC, Roque M, Bedoschi G, Haahr T, Humaidan P. Intracytoplasmic sperm injection for male infertility and consequences for offspring. Nat Rev Urol. 2018;15(9):535-62.
آمار
تعداد مشاهده مقاله: 1,764
تعداد دریافت فایل اصل مقاله: 2,395


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب