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The Modulatory Role of Orexin 1 Receptor in nucleus accumbens(NAc) on spatial memory in rats | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 30 آذر 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.360741.2599 | ||
| نویسندگان | ||
Laleh Zokaei1؛ Esmaeil Akbari   2؛ vahab babapour3؛ morteza zendehdel 3
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| 1Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 2Department of Physiology and Pharmacology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran | ||
| 3Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran | ||
| چکیده | ||
| The neuropeptide orexin is mainly localized to neurons within and around the lateral hypothalamus and exhibits high affinity to orexin 1 and 2 receptors (OX1R, OX2R). Orexinergic neurons send their axons to the nucleus accumbens (NAc), which expresses OX1Rs. Previous studies have shown the involvement of orexins and their roles in learning and memory processes in the dorsal raphe nucleus and hippocampus, but no study has yet examined the effects of orexin in the NAc on memory. In the present study, the effect of post-training and pre-probe of trial intra-NAc administration of SB-33486-A (OX1R antagonist) (12 μg/0.5μl) and TCS-OX2-29 (OX2R antagonist) (10 μg/0.5 μl) on consolidation and retrieval in Morris Water Maze (MWM) task was examined. In experiment 1, rats were trained in MWM and immediately after every training received bilateral injections of Dimethyl sulfoxide (DMSO) (control group), SB-334867-A, and TCS-OX2-29 into NAc. Experiment 2 was similar to experiment 1 except rats received DMSO, SB-33486-A, and TCS-OX2-29, 15 minutes before the probe test. Then, probe and visible tests were performed after the last training and distance moved, escape latency, and velocity were recorded. In experiment 3, rats trained in experiments 1 and 2 immediately after the probe test were given the trials for visuo-motor coordination assessment on the visible platform. According to the results, injection of SB-334867-A, could increased distance moved and escape latency compared to the control group in consolidation phase of spatial memory (P < 0.05), but not in the retrieval phase of spatial memory (P > 0.05). However, TCS-OX2-29 had no effect. These results suggested that the inactivation of NAs OX1Rs but not OX2Rs impairs consolidation but not retrieval of spatial memory in rats. | ||
| کلیدواژه‌ها | ||
| Orexin receptors؛ Memory؛ Nucleus accumbens | ||
| عنوان مقاله [English] | ||
| نقش میانجیگری گیرنده های اورکسینی 1 در هسته آکومبنس بر حافظه فظایی در رت ها | ||
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آمار تعداد مشاهده مقاله: 65 |
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