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Rahimi, Fariba, zendehdel, morteza, Rezaee, Mohammad Jaafar, vazir, bita, Fakour, shahin. (1402). The effects of melatonin alone or in combination with zinc on gonadotropin and thyroid hormones in female rats. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2023.362054.2718
Fariba Rahimi; morteza zendehdel; Mohammad Jaafar Rezaee; bita vazir; shahin Fakour. "The effects of melatonin alone or in combination with zinc on gonadotropin and thyroid hormones in female rats". سامانه مدیریت نشریات علمی, , , 1402, -. doi: 10.22092/ari.2023.362054.2718
Rahimi, Fariba, zendehdel, morteza, Rezaee, Mohammad Jaafar, vazir, bita, Fakour, shahin. (1402). 'The effects of melatonin alone or in combination with zinc on gonadotropin and thyroid hormones in female rats', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2023.362054.2718
Rahimi, Fariba, zendehdel, morteza, Rezaee, Mohammad Jaafar, vazir, bita, Fakour, shahin. The effects of melatonin alone or in combination with zinc on gonadotropin and thyroid hormones in female rats. سامانه مدیریت نشریات علمی, 1402; (): -. doi: 10.22092/ari.2023.362054.2718

The effects of melatonin alone or in combination with zinc on gonadotropin and thyroid hormones in female rats

Archives of Razi Institute
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 17 اردیبهشت 1402
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2023.362054.2718
نویسندگان
Fariba Rahimi1؛ morteza zendehdel* 2؛ Mohammad Jaafar Rezaee3؛ bita vazir1؛ shahin Fakour4
1Department of Basic Science, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran
3Department of Anatomy, Faculty of Medicine, Kurdistan of Medical Science, Sanandaj, Iran
4Department of Clinical Science, Faculty of Veterinary Medicine, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran
چکیده
Thyroid and gonadotropin hormones play an essential role in regulating various physiological functions. The effects of melatonin and zinc (Zn) on these hormones have already been investigated. The current research was aimed to examine the effect of melatonin with and without zinc on the gonadotropin hormones and thyroid hormones (tri-iodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH)) levels in female rats. In general, 35 mature female rats were randomly separated into five treatment groups, each group including 7 rats, in a completely randomized design (CRD) during the research. Rats were treated daily by gavage with Zn and melatonin as follows: T1 (control 1, basal diet), T2 (control 2, treated with normal saline), and other experimental groups, including T3, T4 and T5 were treated with doses of Zn (40 ppm), melatonin (5 mg/kg), and combination of Zn plus melatonin with the same level, respectively. The administration of drugs was continued for 20 days (daily) after which the plasma samples were obtained for determination of LH, FFH, LH/FSH, estrogen, progestron, T3, T4 and TSH levels. Results showed no significant variations between treatments in the FSH and LH amounts. Estrogen, progesterone, and TSH levels in rats that received 5 mg of melatonin per day were higher than other groups, but not statistically significant (P>0.05). However, concentration of T3 significantly decreased in the group that received 40 mg/kg of Zn in comparison with other experiments. (P<0.05). The results showed no meaningful deviation among the treatments in T4 level (P>0.05). In conclusion, except for T3, no remarkable changes were observed in other variables in female rats that received melatonin, Zn or a combination of melatonin and Zn.
کلیدواژه‌ها
Zinc؛ Melatonin؛ Thyroid؛ Gonadotropin؛ Female Rat
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تعداد مشاهده مقاله: 15


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