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Sumardi, Rosnidar, Rifai, Yusnita, Alam, Gemini. (1402). Synthesis of Remdesivir Derivatives as a Generation of Anti-COVID-19 Drugs Through Acetylation Reactions. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2023.361717.2674
Rosnidar Sumardi; Yusnita Rifai; Gemini Alam. "Synthesis of Remdesivir Derivatives as a Generation of Anti-COVID-19 Drugs Through Acetylation Reactions". سامانه مدیریت نشریات علمی, , , 1402, -. doi: 10.22092/ari.2023.361717.2674
Sumardi, Rosnidar, Rifai, Yusnita, Alam, Gemini. (1402). 'Synthesis of Remdesivir Derivatives as a Generation of Anti-COVID-19 Drugs Through Acetylation Reactions', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2023.361717.2674
Sumardi, Rosnidar, Rifai, Yusnita, Alam, Gemini. Synthesis of Remdesivir Derivatives as a Generation of Anti-COVID-19 Drugs Through Acetylation Reactions. سامانه مدیریت نشریات علمی, 1402; (): -. doi: 10.22092/ari.2023.361717.2674

Synthesis of Remdesivir Derivatives as a Generation of Anti-COVID-19 Drugs Through Acetylation Reactions

Archives of Razi Institute
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 21 خرداد 1402
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2023.361717.2674
نویسندگان
Rosnidar Sumardi* 1؛ Yusnita Rifai2؛ Gemini Alam2
1Faculty of Pharmacy, Hasanuddin University, makassar, Indonesia
2Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia
چکیده
Remdesivir, a competitive inhibitor of viral RNA-dependent RNA polymerase (RdRp), is the drug of choice for anti-COVID-19 treatment. However, the instability of these substances in plasma raises doubts about their therapeutic potency. Additionally, SARS-CoV-2-infected cells may exhibit a variety of antiviral behaviors as a result of the intricate activation pathways. The objective of this research is to develop a synthesis for remdesivir derivatives.
Remdesivir derivative was synthesized using acetyl chloride as a reagent in a ratio of 1:3 in dichloromethane and tetrahydrofuran solvent at 30°C for 6 hours. Thin layer chromatography (TLC) and spectrophotometer (1H NMR and 13C NMR) were used to identify the produced molecule that was discovered as a brownish-yellow crystalline powder. The results of the synthesis yielded 0.8 grams (77.34%), Rf value of remdesivir derivate is 0.54, and the characterization with 1H NMR at δ2.5 ppm (3H, s) indicated the presence of a proton in the H-C-C=O structure caused by the substitution of the acetyl group in the remdesivir structure, and the 13C NMR data indicated the presence of aromatic carbons, alkenes, C≡N, and carbon bonds with electronegative O. This remdesivir derivate chemical become a potential candidate for an anti-covid-19 drugs that has more potency because it has substitutions of acetyl groups at positions 2' and 3' in the structure of remdesivir.
کلیدواژه‌ها
Covid-19؛ Synthesis؛ Remdesivir؛ Remdesivir Derivate؛ Acetylation
آمار
تعداد مشاهده مقاله: 48


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