- همه نشریات
- نشریات علمی سازمان تحقیقات، آموزش و ترویچ کشاورزی
- مجلات ترویجی سازمان تحقیقات، آموزش و ترویج کشاورزی
- سایر نشریات سازمان تحقیقات، آموزش و ترویج کشاورزی
- نشریات علمی انجمن ها
- علوم آب و خاک
- علوم اقتصاد و ترویج کشاورزی
- علوم جنگل, مرتع و آبخیزداری
- علوم دامی و شیلات
- علوم زراعی و باغی
- علوم گیاهپزشکی
- علوم مهندسی و مکانیزاسیون کشاورزی
- نشریات با زبان انگلیسی
- نشریات با زبان فارسی
- نشریات دانشگاه آزاد اسلامی
- نشریات علمی
پیوندهای مفید
اخبار و اعلانات
آمار
| تعداد نشریات | 284 |
| تعداد نشریات سازمان | 83 |
| تعداد شماره‌ها | 2,603 |
| تعداد مقالات | 29,892 |
| تعداد مشاهده مقاله | 18,740,593 |
| تعداد دریافت فایل اصل مقاله | 14,162,173 |
Apoptosis induction by new coumarin derivatives in a mice model of breast cancer | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 21 خرداد 1402 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2023.362087.2722 | ||
| نویسندگان | ||
| Mehran Mesgari Abbasi1؛ Monireh Khordadmehr* 2؛ Dariush Shanehbandi3؛ Farinaz Jigari-Asl2؛ Reza Teimuri-Mofrad4؛ Shabnam Tahmasebi4؛ Mohammad Shahab Asar5؛ Fatemeh Eskandari1؛ Yousef Panahi6 | ||
| 1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 2Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran | ||
| 3Immunology research center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 4Department of Organic and Biochemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran | ||
| 5Faculty of Veterinary Medicine, Shabestar Branch, Islamic Azad University, Shabestar, Iran | ||
| 6Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran | ||
| چکیده | ||
| Background: In recent decades, a large number of studies have focused on finding novel agents for the suppression of cancer cell growth. This study evaluated the effect of the two novel synthetic coumarin derivatives, including 2-amino-4-(4-(2-hydroxyethoxy)-3-methoxyphenyl)-5-oxo-4H,5H-pyrano[3,2-c]coumarin-3-carbonitrile and 2-amino-4-(4-hydroxyphenyl)-5-oxo-4H,5H-pyrano[3,2-c]coumarin-3-carbonitrile on induction of apoptosis in breast cancer in a mice model. Methods: The breast cancer was induced in BALB/c mice, which were divided randomly into six groups, and the experiment was performed. The groups and treatments included A1/ coumarin A with a low-dose (10µm), A2/ coumarin A with a high-dose (1 mM), B1/ coumarin B with a low-dose (10µm), B2/ coumarin B with a high-dose (1 mM), D (Doxorubicin), and C (cancer control/treated by normal saline). The treatments were performed for five weeks. The animals were euthanized, and the tissue samples, including lung, liver, and tumor mass, were taken for histopathological examinations. Besides, qRT-PCR was conducted to evaluate some apoptotic markers, such as BCL-2, Caspase-9, COX-2, and c-Myc. Results: The qRT-PCR presented that both coumarin compounds could significantly alter the expression levels of BCL-2, Caspase-9, COX-2, and c-Myc. Also, consistent with these results, histopathological observations showed a notable reduction of pathological lesions and severity of malignancy in tumor mass and reduced microscopic metastases in the lung and liver. Conclusion: Here, it is concluded that the present new coumarin compounds can induce apoptosis in the breast cancer cells by altering some apoptosis-related genes that may have a chemotherapeutic role in breast cancer therapy in the future. | ||
| کلیدواژه‌ها | ||
| programmed cell death؛ chemotherapy؛ doxorubicin؛ natural products | ||
| عنوان مقاله [English] | ||
| القاء آپپتوز به وسیله مشتقات جدید کومارین در مدل موشی سرطان پستان | ||
|
آمار تعداد مشاهده مقاله: 78 |
||
سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب