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| تعداد نشریات | 284 |
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Histopathological changes of induced thin layer endometrium by pentoxifylline and pentoxifylline loaded-plga effectiveness in female rats | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 30 خرداد 1402 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2023.361848.2693 | ||
| نویسندگان | ||
| S. S Raheem1؛ H. F Hasan2؛ A. H Abid Ali* 3، 4؛ A. M Jasim5 | ||
| 1Department of Community Health, College of Health and Medical Techniques, Al_FuratAl_Awsat Technical University, 31003 Al-Kufa, Iraq | ||
| 2Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq | ||
| 3Department of Medical Laboratory Techniques, College of Health and Medical Techniques, Al-Furat Al-Awsat Technical University, Kufa, Iraq | ||
| 4Southern Federal University, st. B. Sadovaya, 105/42, 344006 Rostov-on-Don, Russian | ||
| 5Department of Pharmacology and Toxicology, College of Veterinary Medicine, Al-Qasim Green University, Al Qasim, Iraq | ||
| چکیده | ||
| Pentoxifylline is the vasoactive agents that have an significant role in treatment the thin layer endometrium case. Pentoxifylline, also identified as oxpentifylline, is a member of xanthine derivatives, and it is a competitive nonselective phosphodiesterase inhibitor leading to elevates of intracellular cAMP, inhibits TNF and leukotriene synthesis, activates PKA, reduces inflammation and innate immunity, and used as an agent to relieve muscle pain in people with peripheral artery disease (vascular irregularities) and is also a acceptable choice for radiation-induced fibrosis. Therefore, determination the advantageous impact of Pentoxifylline (PTX) and Pentoxifylline loaded Poly Lactic-co-Glycolic Acid (PLGA) was the objective of this study to female rats after being exposed to ethanol to create a thin layer of endometrium, fifty female rats were divided into five groups (G1: negative normal control, G2: positive control, G3: empty PLGA, G4: preference PTX, and G5: PLGA- PTX groups) for a twenty-day treatment period. In this study noticed the histopathogical section revealed a perfect improvement in the tissues of uterine horn of female rats that induced endometrial and treated with PLGA-Pentoxifylline when it appeared a clear healing and an increase in the thickness of endometrium and myometrium in comparison with the ordinary Pentoxifylline treated group that noticed the lowest in recovery characteristics, whilst the positive control group is shown a decrease significantly in the endometrium, myometrium thickness, vascular and glandular density. This study showed that the PTX-loaded PLGA had the capacity to in healing thin layer endometrium with improving the levels of histopathological changes, especially regarding with a thickness of endometrium and myometrium more than an ordinary Pentoxifylline treated group. | ||
| کلیدواژه‌ها | ||
| Pentoxifylline loaded PLGA؛ Endometrium female rats؛ Nanoparticles؛ Myometrium thickness؛ Vascular and Glandular density | ||
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آمار تعداد مشاهده مقاله: 64 |
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