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Shahsavari, Sara, Bakht, Mehdi, Sadeghi, Hamid, Rahimi, Sara, Movahed, Farideh, Chegini, Venus, Gholamzadeh Khoei, Saeideh. (1402). Effect of diabetes mellitus on the spectrum of uropathogens and the antimicrobial resistance in patients with urinary tract infection. سامانه مدیریت نشریات علمی, 79(1), 92-101. doi: 10.32592/ARI.2024.79.1.92
Sara Shahsavari; Mehdi Bakht; Hamid Sadeghi; Sara Rahimi; Farideh Movahed; Venus Chegini; Saeideh Gholamzadeh Khoei. "Effect of diabetes mellitus on the spectrum of uropathogens and the antimicrobial resistance in patients with urinary tract infection". سامانه مدیریت نشریات علمی, 79, 1, 1402, 92-101. doi: 10.32592/ARI.2024.79.1.92
Shahsavari, Sara, Bakht, Mehdi, Sadeghi, Hamid, Rahimi, Sara, Movahed, Farideh, Chegini, Venus, Gholamzadeh Khoei, Saeideh. (1402). 'Effect of diabetes mellitus on the spectrum of uropathogens and the antimicrobial resistance in patients with urinary tract infection', سامانه مدیریت نشریات علمی, 79(1), pp. 92-101. doi: 10.32592/ARI.2024.79.1.92
Shahsavari, Sara, Bakht, Mehdi, Sadeghi, Hamid, Rahimi, Sara, Movahed, Farideh, Chegini, Venus, Gholamzadeh Khoei, Saeideh. Effect of diabetes mellitus on the spectrum of uropathogens and the antimicrobial resistance in patients with urinary tract infection. سامانه مدیریت نشریات علمی, 1402; 79(1): 92-101. doi: 10.32592/ARI.2024.79.1.92

Effect of diabetes mellitus on the spectrum of uropathogens and the antimicrobial resistance in patients with urinary tract infection

Archives of Razi Institute
مقاله 10، دوره 79، شماره 1، فروردین و اردیبهشت 2024، صفحه 92-101    اصل مقاله (335.96 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2024.79.1.92
نویسندگان
Sara Shahsavari1؛ Mehdi Bakht1؛ Hamid Sadeghi1؛ Sara Rahimi1؛ Farideh Movahed2؛ Venus Chegini2؛ Saeideh Gholamzadeh Khoei* 1، 2
1Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran
2Clinical Research Development Unit, Kowsar Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
چکیده
Background: Patients with diabetes mellitus (DM) frequently experience urinary tract infections. Many studies indicated that diabetes patients experience higher treatment costs, morbidity, and death due to UTI as a result of the spread of resistant bacterial strains in hospitals. In the current study, we looked at how glycemic control affects diabetic patients'''' rates of UTI, the pathogens that cause them, the presence of multi-drug-resistant (MDR) and extensively drug-resistant (XDR) organisms, and the infections'''' relation to diabetes.
Methods: Diabetes patients'''' midstream urine (MSU) samples were taken in a sterile, spotless, and dry wide-mouthed bottle. After following the standard methodology to collect and identify the organisms, disc diffusion antibiotic sensitivity tests were conducted. HbA1c measured for all patients. Using the SPSS 16.0 version, the data were examined.
Results: In the current study, 500 diabetic patients provided urine samples, after analyzing of urines it was revealed that189 (37.2%) of those individuals had UTI. Compared to 59 patients with managed glycemia, 130 individuals in the uncontrolled glycemic group experienced the most UTI cases. In both diabetic groups, females had a significantly higher prevalence of UTI than males (88.4% and 11.6%, respectively, 𝑃 < 0.004). 52.3% of women over 46 with uncontrolled glycemia experienced UTIs. The most common bacterial isolate, E. coli, displayed 58.4% MDR.
Conclusion: These findings demonstrate that, regardless of age or gender, glycemic control in diabetes patients is essential for decreasing UTI rates. It should be noted that, the best empirical treatment for diabetic patients with UTI should involve regular monitoring of the uropathogenic susceptibility patterns.
کلیدواژه‌ها
UTI؛ Diabetes mellitus؛ antibacterial resistance؛ glycemia
عنوان مقاله [English]
تاثیر دیابت بر پاتوژن های ادراری و مقاومت ضد میکروبی در بیماران مبتلا به عفونت ادراری
چکیده [English]
زمینه و هدف: بیماران مبتلا به دیابت ملیتوس اغلب دچار عفونت های مجاری ادراری می شوند. بیماران دیابتی در نتیجه گسترش سویه‌های باکتریایی مقاوم در بیمارستان‌ها، هزینه‌های درمانی وعوارض ناشی از UTI بالاتری را تجربه می‌کنند. در مطالعه حاضر، ما به چگونگی تأثیر کنترل قند خون بر میزان UTI در بیماران دیابتی، و همچنین پاتوژن هایی که آنها را ایجاد می کنند، وجود ارگانیسم های مقاوم به چند دارو و ارتباط عفونت ها با دیابت را بررسی کردیم.
روش‌ها: نمونه‌های ادرار میانی بیماران دیابتی در یک بطری دهان گشاد استریل جمع آوری کرده و طبق روش استاندارد برای جمع‌آوری و شناسایی ارگانیسم‌ها، آزمایش‌های حساسیت آنتی‌بیوتیکی انتشار دیسک انجام شد. HbA1c برای همه بیماران اندازه گیری شد. با استفاده از نسخه SPSS 16.0 داده ها مورد بررسی قرار گرفت.
یافته‌ها: 500 بیمار دیابتی نمونه ادرار خود را برای این مطالعه ارائه کردند که 189 نفر (2/37%) مبتلا به عفونت ادراری بودند. در مقایسه با 59 بیمار مبتلا به قند خون مدیریت شده، 130 نفر در گروه قند کنترل نشده بیشترین موارد UTI را تجربه کردند. در هر دو گروه دیابتی، زنان به طور قابل توجهی شیوع UTI بالاتری نسبت به مردان داشتند (به ترتیب 88.4% و 11.6%، ❑ < 0.004). 52.3 درصد از زنان بالای 46 سال مبتلا به قند خون کنترل نشده عفونت ادراری را تجربه کردند. شایع ترین ایزوله باکتری، E. coli، 58.4% MDR را نشان داد.
نتیجه‌گیری: این یافته‌ها نشان می‌دهد که بدون در نظر گرفتن سن یا جنسیت، کنترل قند خون در بیماران دیابتی برای کاهش میزان UTI ضروری است. بهترین درمان تجربی برای بیماران دیابتی مبتلا به UTI باید شامل نظارت منظم بر الگوهای حساسیت ادراری پاتوژن باشد.
کلیدواژه‌ها [English]
UTI, دیابت ملیتوس, مقاومت آنتی باکتریال, گلیسمی
مراجع
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