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Membrane trafficking mechanisms and their biological relevance | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 26 شهریور 1402 | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2023.362844.2783 | ||
| نویسنده | ||
| Akinwunmi Oluwaseun Adeoye* | ||
| Department of Biochemistry, Faculty of Science, Federal University Oye-Ekiti | ||
| چکیده | ||
| The majority of chemicals expressed in mammalian cells have complex delivery and transport mechanisms to get to the right intracellular sites. Numerous cellular organelles which include the plasma membrane, have their size, shape, and molecular makeup regulated by membrane transport. One of these transports the majority of transmembrane proteins as well as nearly all secreted proteins from the endoplasmic reticulum, where they are created, to their final sites. Nearly all eukaryotic cells contain a membrane-trafficking mechanism, which is both a prominent and critical component. This system, which is composed of compartments that are dynamically coupled, supports the export and uptake of extracellular material, remodeling and signaling at the cellular interface, intracellular targeting, and preservation of internal compartmentalization (organelles). This system permits both regular cellular activity and specialized tasks, such as neural transmission and hormone control, in animal cells. Human disease, including neurodegenerative conditions like Alzheimer's disease, heart disease, and cancer, is linked to disruption or dysregulation of the membrane-trafficking system. The treatment and cure of human disease depend on understanding the cellular and molecular principles underpinning membrane trafficking routes. A single gene mutation or mutations that result in impaired membrane trafficking give rise to a number of clinical disorders brought on by modifications in cellular homeostasis. Other eukaryotic creatures with significant economic and agricultural value, like plants and fungi, also depend on the membrane-trafficking system for survival. This review emphasizes the major human disorders connected to the process of membrane trafficking while concentrating on a broad overview of membrane trafficking. | ||
| کلیدواژه‌ها | ||
| Membrane trafficking؛ membrane proteins؛ exocytosis؛ endocytosis؛ vesicular transport | ||
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آمار تعداد مشاهده مقاله: 71 |
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