اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان83
تعداد شماره‌ها2,644
تعداد مقالات30,248
تعداد مشاهده مقاله20,345,677
تعداد دریافت فایل اصل مقاله14,704,440
Elizondo-Quiroga, Darwin, De Los Santos-Acuña, Maria, Gutierrez-Ortega, Abel, Galan-Martinez, Claudia, Pedroza-Roldan, Cesar. (1402). Genome sequences of Canine Parvovirus type 2c prevalent in Western Mexico. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2023.363230.2825
Darwin Elizondo-Quiroga; Maria Alejandra De Los Santos-Acuña; Abel Gutierrez-Ortega; Claudia Galan-Martinez; Cesar Pedroza-Roldan. "Genome sequences of Canine Parvovirus type 2c prevalent in Western Mexico". سامانه مدیریت نشریات علمی, , , 1402, -. doi: 10.22092/ari.2023.363230.2825
Elizondo-Quiroga, Darwin, De Los Santos-Acuña, Maria, Gutierrez-Ortega, Abel, Galan-Martinez, Claudia, Pedroza-Roldan, Cesar. (1402). 'Genome sequences of Canine Parvovirus type 2c prevalent in Western Mexico', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2023.363230.2825
Elizondo-Quiroga, Darwin, De Los Santos-Acuña, Maria, Gutierrez-Ortega, Abel, Galan-Martinez, Claudia, Pedroza-Roldan, Cesar. Genome sequences of Canine Parvovirus type 2c prevalent in Western Mexico. سامانه مدیریت نشریات علمی, 1402; (): -. doi: 10.22092/ari.2023.363230.2825

Genome sequences of Canine Parvovirus type 2c prevalent in Western Mexico

Archives of Razi Institute
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 02 آبان 1402
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2023.363230.2825
نویسندگان
Darwin Elizondo-Quiroga1؛ Maria Alejandra De Los Santos-Acuña2؛ Abel Gutierrez-Ortega1؛ Claudia Galan-Martinez2؛ Cesar Pedroza-Roldan* 3
1Unidad de Biotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C. Guadalajara, Jalisco, México.
2Departmento de Medicina Veterinaria, Centro Universitario de Ciencias Biológicas Y Agropecuarias, Universidad de Guadalajara, Zapopan, Jalisco, México.
3Departamento de Medicina Veterinaria, Centro Universitario de Ciencias Biológicas y Agropecuarias. Universidad de Guadalajara. Zapopan, Jalisco, Mexico.
چکیده
Canine Parvovirus 2 is one of the main etiologies of viral gastroenteritis in dogs worldwide. This disease is characterized mainly by the presence of diarrhea, abdominal pain, vomiting, anorexia and dehydration. This virus is responsible for a high mortality and morbidity rate in dogs younger than 3 months and those incomplete or not vaccinated. Monitoring of viral variants in our region has shown that in the last 7 years, variant 2c has been circulating exclusively, which is unusual if we consider that in the rest of the world at least 2 variants co-circulate among dog populations. In Mexico, there are no studies that report genomic sequences of CPV-2 which are relevant for population comparisons at the genetic level; thus, the purpose of the present study was to sequence genomes associated with CPV-2c. To meet this objective, stool samples were collected from dogs with suspected CPV-2 infection; five positive cases diagnosed by lateral flow testing and PCR were selected for viral genome sequencing. Comparative analyses showed that the genome sequences obtained were >99% homologous to those reported for CPV-2 in GenBank. On the other hand, 52 nucleotide mutations were identified in the vp1/vp2 gene of which 3 impacted the amino acid transition (T226S, F267Y, A440T). Phylogenetic analysis of the vp1/vp2 gene showed that the five sequences cluster in a clade called "III", which is related to sequences from USA and Uruguay. To our knowledge, this is the first report of genomic sequences associated with CPV-2 in Mexico, which is of great relevance for the epidemiological-molecular understanding and evolution of the virus.
کلیدواژه‌ها
Canine parvovirus type 2c؛ genome؛ Mexico
آمار
تعداد مشاهده مقاله: 27


counter
سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب