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Hamzah, Nurraihana, Safuan, Sabreena, Wan Ishak, Wan Rosli. (1403). Protective Effects of the Phenolic-rich Fraction of Young Corn Silk (Zea mays L.) against Pancreatic Islet Destruction in Streptozotocin-induced Diabetic Rats. سامانه مدیریت نشریات علمی, 13(3), 614-620. doi: 10.22034/jmpb.2023.359722.1497
Nurraihana Hamzah; Sabreena Safuan; Wan Rosli Wan Ishak. "Protective Effects of the Phenolic-rich Fraction of Young Corn Silk (Zea mays L.) against Pancreatic Islet Destruction in Streptozotocin-induced Diabetic Rats". سامانه مدیریت نشریات علمی, 13, 3, 1403, 614-620. doi: 10.22034/jmpb.2023.359722.1497
Hamzah, Nurraihana, Safuan, Sabreena, Wan Ishak, Wan Rosli. (1403). 'Protective Effects of the Phenolic-rich Fraction of Young Corn Silk (Zea mays L.) against Pancreatic Islet Destruction in Streptozotocin-induced Diabetic Rats', سامانه مدیریت نشریات علمی, 13(3), pp. 614-620. doi: 10.22034/jmpb.2023.359722.1497
Hamzah, Nurraihana, Safuan, Sabreena, Wan Ishak, Wan Rosli. Protective Effects of the Phenolic-rich Fraction of Young Corn Silk (Zea mays L.) against Pancreatic Islet Destruction in Streptozotocin-induced Diabetic Rats. سامانه مدیریت نشریات علمی, 1403; 13(3): 614-620. doi: 10.22034/jmpb.2023.359722.1497

Protective Effects of the Phenolic-rich Fraction of Young Corn Silk (Zea mays L.) against Pancreatic Islet Destruction in Streptozotocin-induced Diabetic Rats

Journal of Medicinal plants and By-products
مقاله 16، دوره 13، شماره 3، آذر 2024، صفحه 614-620    اصل مقاله (494.93 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2023.359722.1497
نویسندگان
Nurraihana Hamzah1؛ Sabreena Safuan2؛ Wan Rosli Wan Ishak* 1
1Nutrition Program, School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
2Biomedicine Program, School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
چکیده
The phytochemical and bioactive characteristics of plants are influenced by their species and varieties. However, not much is known about the ability of baby corn silk in repairing pancreatic damage. In this study, we investigate the protective effects of the phenolic-rich fraction of vegetable variety baby corn silk (PRFsilk) on the pancreas of streptozotocin (STZ)-induced diabetic rats. Thirty rats were divided into five groups, where Group 1 comprised six nondiabetic control rats; Group 2 was diabetic control; Groups 3 and 4 were diabetic rats treated with 100 and 200 mg/kg/day of PRFsilk, respectively; and Group 5 served as diabetic treatment control with 150 mg/kg/day of metformin. After 28 days of administrating PRFsilk, diabetic rats in Groups 3 and 4 had their blood glucose levels significantly lowered by 67.45% and 66.85%, respectively, compared with the diabetic control group, with more insulin detected in their pancreatic homogenates through ELISA assay. The histological assessment found signs of damage and atrophy in the islet cells of all diabetic rats, with the worst observed in the diabetic control group. However, the islets of PRFsilk-treated rats had little damage caused by STZ induction compared with the pancreas of metformin-treated rats, particularly in Group 3, which was treated with a lower PRFsilk dose. This showed that the PRF of baby corn silk could ameliorate STZ-induced pancreatic damage in rats, most likely through its anti-oxidative and immune-boosting properties.
کلیدواژه‌ها
Corn silk؛ Phenolic fraction؛ Pancreas؛ Histology؛ Diabetic rats
مراجع
  1. Zimmet P., Alberti K.G., Magliano D.J., Bennett PH. Diabetes mellitus statistics on prevalence and mortality: facts and fallacies. Nat Rev Endocrinol. 2016;12(10):616–22.
  2. Feldstein I.T., Dyszak G.N. Road crossing decisions in real and virtual environments: a comparative study on simulator validity. Accid Anal Prev [Internet]. 2020;137. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079176496&doi=10.1016%2Fj.aap.2019.105356&partnerID=40&md5=c6e2bdf4991403adfa4b4658b7e2082c.
  3. Gao J., Han Y-L., Jin Z-Y., Xu X-M., Zha X-Q., Chen H-Q., et al. Protective effect of polysaccharides from Opuntia dillenii Haw. fruits on streptozotocin-induced diabetic rats. Carbohydr Polym. 2015;124:25–34.
  4. Shi C., Wu L., Li L. LncRNA-MALAT 1 regulates cardiomyocyte scorching in diabetic cardiomyopathy by targeting NLRP3. Cell Mol Biol. 2021;67(6):213–9.
  5. Li J., Li X., Qiao X. Analysis of circRNA regulatory network in myocardial tissue of type 1 diabetic mice. Cell Mol Biol. 2021;67(3):201–3.
  6. Huo J., Meng G., Jiang X. Influence of Heme Oxygenase-1 on rats with diabetic retinopathy through ERK1/2 signaling pathway. Cell Mol Biol. 2022;68(6):92–7.
  7. Bahadoran Z., Mirmiran P., Azizi F. Dietary polyphenols as potential nutraceuticals in management of diabetes: a review. J Diabetes Metab Disord. 2013;12(1):1–9.
  8. Dragan S., Andrica F., Serban M-C., Timar R. Polyphenols-rich natural products for treatment of diabetes. Curr Med Chem. 2015;22(1):14–22.
  9. Lin D., Xiao M., Zhao J., Li Z., Xing B., Li X., et al. An overview of plant phenolic compounds and their importance in human nutrition and management of type 2 diabetes. Molecules. 2016;21(10):1374.
  10. Aryaeian N., Sedehi S.K., Arablou T. Polyphenols and their effects on diabetes management: a review. Med J Islam Repub Iran. 2017;31:134.
  11. Solayman M., Ali Y., Alam F., Islam A., Alam N., Khalil I., et al. Polyphenols: potential future arsenals in the treatment of diabetes. Curr Pharm Des. 2016;22(5):549–65.
  12. Wan Rosli W.I., Rahman N.A. Cornsilk as an Alternate Functional Ingredient. In: Functional Foods Wonder of the World Evidence-Based Functional Foods in Health & Disease. Selangor, Malaysia: Penerbit Universiti Putra Malaysia; 2017. p. 267–85.
  13. Guo J., Liu T., Han L., Liu Y. The effects of corn silk on glycaemic metabolism. Nutr Metab (Lond). 2009;6(1):1–6.
  14. Zhao W., Yin Y., Yu Z., Liu J., Chen F. Comparison of anti-diabetic effects of polysaccharides from corn silk on normal and hyperglycemia rats. Int J Biol Macromol. 2012;50(4):1133–7.
  15. Zhang Y., Wu L., Ma Z., Cheng J., Liu J. Anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of flavonoids from corn silk on STZ-induced diabetic mice. Molecules. 2016;21(1):7.
  16. Pan Y., Wang C., Chen Z., Li W., Yuan G., Chen H. Physicochemical properties and antidiabetic effects of a polysaccharide from corn silk in high-fat diet and streptozotocin-induced diabetic mice. Carbohydr Polym. 2017;164:370–8.
  17. Riupassa I.E., Kim Y.R., Tenrilili A.N.A., Untung J.S., Djamaludin N.S., Achmad M.A. Corn silk based ethosomal gel: a new treatment for periodontitis in diabetic albino rats a preliminary study. Indian J Public Heal Res Dev. 2020;11(1).
  18. Suzuki R., Okada Y., Okuyama T. The favorable effect of style of Zea mays L. on streptozotocin induced diabetic nephropathy. Biol Pharm Bull. 2005;28(5):919–20.
  19. Sheng L., Chen Q., Di L., Li N. Evaluation of anti-diabetic potential of corn silk in high-fat diet/streptozotocin-induced type 2 diabetes mice model. Endocrine, Metab Immune Disord Targets (Formerly Curr Drug Targets-Immune, Endocr Metab Disord. 2021;21(1):131–8.
  20. Lukitaningtyas D., Sudiana I.K., Bakar A. The effect of corn silk ethanol extract (Zea mays. l) on decreasing the blood glucose levels. Int J Nurs Heal Serv. 2020;3(1):96–100.
  21. Wen X., Yue L. The influence of corn silk polysaccharide on signal pathway of TGF-β1 in type 2 diabetic mellitus rat. Open Biomed Eng J. 2015;9:204.
  22. Nurraihana H., Wan Rosli W.I., Sabreena S., Norfarizan-Hanoon N.A. Optimisation extraction procedure and identification of phenolic compounds from fractional extract of corn silk (Zea mays hair) using LC-TOF/MS system. J. Food Meas Charact. 2018;12(3):1852–62.
  23. Hamzah N., Safuan S., Wan Ishak W.R. Potential effect of polyphenolic-rich fractions of corn silk on protecting endothelial cells against high glucose damage using in vitro and in vivo approaches. Molecules. 2021;26(12):3665.
  24. Rahman F.A.A. Phytochemical screening and antihyperglycaemic activities of Cordyceps sinensis and its based product (ESULIN). Kubang Kerian, Malaysia: Universiti Sains Malaysia; 2016.
  25. Patel S.B., Santani D., Shah M.B., Patel V.S. Anti-hyperglycemic and anti-hyperlipidemic effects of Bryonia laciniosa seed extract and its saponin fraction in streptozotocin-induced diabetes in rats. J Young Pharm. 2012;4(3):171–6.
  26. Kausar M.A., Parveen K., Siddiqui W.A., Anwar S., Zahra A., Ali A., et al. Nephroprotective effects of polyherbal extract via attenuation of the severity of kidney dysfunction and oxidative damage in the diabetic experimental model. Cell Mol Biol. 2021;67(4):42–55.
  27. Testa R., Bonfigli A.R., Genovese S., De Nigris V., Ceriello A. The possible role of flavonoids in the prevention of diabetic complications. Nutrients. 2016;8(5):310.
  28. Iliya I.A., Mohammed B., Akuyam S.A., Yaro J.D., Timbuak J.A., Tanko M., et al. Histological and biochemical evaluation of the antidiabetic potentials of S-allyl-cysteine and mangiferin in type 2 diabetic rat models. Sub-Saharan African J Med. 2016;3(1):32.
  29. Bergman R.N., Finegood D.T., Ader M. Assessment of insulin sensitivity in vivo. Endocr Rev. 1985;6(1):45–86.
  30. Xiangyang Q., Weijun C., Liegang L., Ping Y., Bijun X. Effect of a Siraitia grosvenori extract containing mogrosides on the cellular immune system of type 1 diabetes mellitus mice. Mol Nutr Food Res. 2006;50(8):732–8.
  31. Ghorbani A., Rashidi R., Shafiee-Nick R. Flavonoids for preserving pancreatic beta cell survival and function: a mechanistic review. Biomed Pharmacother. 2019;111:947–57.
  32. Ortsäter H., Grankvist N., Wolfram S., Kuehn N., Sjöholm Å. Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in db/db mice. Nutr Metab (Lond). 2012;9(1):1–10.
  33. Kang Y-J., Jung U.J., Lee M-K., Kim H-J., Jeon S-M., Park Y.B., et al. Eupatilin, isolated from Artemisia princeps Pampanini, enhances hepatic glucose metabolism and pancreatic β-cell function in type 2 diabetic mice. Diabetes Res Clin Pract. 2008;82(1):25–32.
  34. Bashir N., Manoharan V., Miltonprabu S. Grape seed proanthocyanidins protects against cadmium induced oxidative pancreatitis in rats by attenuating oxidative stress, inflammation and apoptosis via Nrf-2/HO-1 signaling. J Nutr Biochem. 2016;32:128–41.
  35. Newsholme P., Rebelato E., Abdulkader F., Krause M., Carpinelli A., Curi R. Reactive oxygen and nitrogen species generation, antioxidant defenses, and β-cell function: a critical role for amino acids. J Endocrinol. 2012;214(1):11–20.
  36. Liu C., Dai L., Liu Y., Dou D., Sun Y., Ma L. Pharmacological activities of mogrosides. Vol. 10, Future Medicinal Chemistry. Future Sci. 2018. p. 845–50.
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