اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,036
تعداد مقالات33,971
تعداد مشاهده مقاله45,644,475
تعداد دریافت فایل اصل مقاله75,863,955
Safaeinejad, Fahimeh, Soodi, Maliheh, Esmaeili, Somayeh, Jafari, Fatemeh, Shirzad Kebria, Maedeh, Keramatian, Behnaz, Hajimehdipoor, Homa, Rajabi, Sadegh. (1403). Anti-fatigue and Antioxidant Effects of Aqueous Extract of Echium amoenum on a Rat Model of Acute Fatigue. سامانه مدیریت نشریات علمی, 13(Special), 855-862. doi: 10.22034/jmpb.2023.363436.1601
Fahimeh Safaeinejad; Maliheh Soodi; Somayeh Esmaeili; Fatemeh Jafari; Maedeh Shirzad Kebria; Behnaz Keramatian; Homa Hajimehdipoor; Sadegh Rajabi. "Anti-fatigue and Antioxidant Effects of Aqueous Extract of Echium amoenum on a Rat Model of Acute Fatigue". سامانه مدیریت نشریات علمی, 13, Special, 1403, 855-862. doi: 10.22034/jmpb.2023.363436.1601
Safaeinejad, Fahimeh, Soodi, Maliheh, Esmaeili, Somayeh, Jafari, Fatemeh, Shirzad Kebria, Maedeh, Keramatian, Behnaz, Hajimehdipoor, Homa, Rajabi, Sadegh. (1403). 'Anti-fatigue and Antioxidant Effects of Aqueous Extract of Echium amoenum on a Rat Model of Acute Fatigue', سامانه مدیریت نشریات علمی, 13(Special), pp. 855-862. doi: 10.22034/jmpb.2023.363436.1601
Safaeinejad, Fahimeh, Soodi, Maliheh, Esmaeili, Somayeh, Jafari, Fatemeh, Shirzad Kebria, Maedeh, Keramatian, Behnaz, Hajimehdipoor, Homa, Rajabi, Sadegh. Anti-fatigue and Antioxidant Effects of Aqueous Extract of Echium amoenum on a Rat Model of Acute Fatigue. سامانه مدیریت نشریات علمی, 1403; 13(Special): 855-862. doi: 10.22034/jmpb.2023.363436.1601

Anti-fatigue and Antioxidant Effects of Aqueous Extract of Echium amoenum on a Rat Model of Acute Fatigue

Journal of Medicinal plants and By-products
مقاله 14، دوره 13، Special، بهمن 2024، صفحه 855-862    اصل مقاله (973.13 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2023.363436.1601
نویسندگان
Fahimeh Safaeinejad1؛ Maliheh Soodi2، 3؛ Somayeh Esmaeili4؛ Fatemeh Jafari1؛ Maedeh Shirzad Kebria2؛ Behnaz Keramatian1؛ Homa Hajimehdipoor* 4؛ Sadegh Rajabi* 1
1Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
3Institute of Natural Products and Medicinal Plants, Tarbiat Modares University, Tehran, Iran
4Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Echium amoenum Fisch. & C.A.Mey. has been used for the management of the common cold, inflammation, depression, anxiety, and fatigue. This study aimed to explore the anti-fatigue and antioxidant effects of aqueous extract of E. amoenum (AEEA) on a rat model of acute fatigue. After preparing for AEEA, 30 Wistar rats were divided into five groups of six animals. Group 1 received distilled water; Group 2 was treated with distilled water and underwent a forced swimming test (FST); Groups 3-5 rats were administered AEEA (250, 500, and 1000 mg/kg), and subsequently underwent FST. Then, the levels of some biochemical parameters and oxidative stress markers were measured in the serum and liver tissues of rats. AEEA treatment significantly augmented the swimming time of rats compared to the control group. AEEA-treated animals had increased serum glucose and decreased serum urea levels. AEEA diminished serum activities of creatine phosphokinase (CPK) and lactate dehydrogenase (LDH). Treating the rats with AEEA activated superoxide dismutase (SOD) and catalase (CAT) and decreased total oxidant status (TOS) in serum. AEEA increased the levels of thiols and glutathione (GSH) as well as the activity of glutathione peroxidase (GPx) and CAT in the liver tissues. In the liver tissue, AEEA also induced the activity of SOD and reduced TOS. These results may suggest AEEA as a potential anti-fatigue natural product to ameliorate the adverse effects of acute fatigue on the body.
کلیدواژه‌ها
Anti-oxidant؛ Echium amoenum؛ Fatigue؛ Forced swimming test؛ Oxidative stress؛ Rat
مراجع
  1. Zhang G., Lu B., Wang E., Wang W., Li Z., Jiao L., Li H., Wu W. Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway. Pharm. Biol. 2023;61(1): 316-323.
  2. Arring N.M., Millstine D., Marks L.A., Nail L.M. Ginseng as a Treatment for Fatigue: A Systematic Review. J. Altern Complement Med. 2018;24(7):624-633.
  3. Penner I.K., Paul F. Fatigue as a symptom or comorbidity of neurological diseases. Nat. Rev. Neurol. 2017; 13 (11): 662-675.
  4. Wei W., Li Z.P., Zhu T., Fung H.Y., Wong T.L., Wen X., Ma D.L., Leung CH., Han Q.B. Anti-Fatigue Effects of the Unique Polysaccharide Marker of Dendrobium officinale on BALB/c Mice. Molecules. 2017;22(1): 155.
  5. Mizuno K., Tanaka M., Nozaki S., Mizuma H., Ataka S., Tahara T., Sugino T., Shirai T., Kajimoto Y., Kuratsune H., Kajimoto O., Watanabe Y. Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition. 2008; 24 (4): 293-299.
  6. Liu R., Wu L., Du Q., Ren J.W., Chen QH, Li D, Mao RX, Liu XR, Li Y. Small Molecule Oligopeptides Isolated from Walnut (Juglans regia L.) and Their Anti-Fatigue Effects in Mice. Molecules. 2018; 24 (1): 45.
  7. Xu J., Potter M., Tomas C., Elson J.L., Morten K.J., Poulton J., Wang N., Jin H., Hou Z., Huang W.E. A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy. Analyst. 2019; 144 (3):913-920.
  8. Twisk F.N. The status of and future research into Myalgic Encephalomyelitis and Chronic Fatigue Syndrome: the need of accurate diagnosis, objective assessment, and acknowledging biological and clinical subgroups. Front Physiol. 2014; 5 (1): 109.
  9. Lee J.S., Kim H.G., Lee D.S., Son C.G. Oxidative Stress is a Convincing Contributor to Idiopathic Chronic Fatigue. Sci. Rep. 2018;8(1):12890.
  10. Samimi F., Baazm M., Eftekhar E., Rajabi S., Goodarzi M.T., Jalali Mashayekhi F. Possible antioxidant mechanism of coenzyme Q10 in diabetes: impact on Sirt1/Nrf2 signaling pathways. Res. Pharm. Sci. 2019;14 (6): 524-533.
  11. Soodi M., Saeidnia S., Sharifzadeh M., Hajimehdipoor H., Dashti A., Sepand M.R., Moradi S. Satureja bachtiarica ameliorate beta-amyloid induced memory impairment, oxidative stress and cholinergic deficit in animal model of Alzheimer's disease. Metab. Brain. Dis. 2016; 31(2):395-404.
  12. Zal F., Taheri R., Khademi F., Keshavarz E., Rajabi S., Mostafavi-Pour Z. The combined effect of furosemide and propranolol on GSH homeostasis in ACHN renal cells. Toxicol. Mech. Methods. 2014; 24 (6): 412-416.
  13. Kahkeshani N., Razzaghirad Y., Ostad S.N., Hadjiakhoondi A., Shams Ardekani M.R., Hajimehdipoor H., Attar H., Samadi M., Jovel E., Khanavi M. Cytotoxic, acetylcholinesterase inhibitor and antioxidant activity of Nepeta menthoides Boiss & Buhse essential oil. J Essen Oil Bear Plants. 2014; 17 (4): 544-552.
  14. Fukuda S., Nojima J., Motoki Y., Yamaguti K., Nakatomi Y., Okawa N., Fujiwara K., Watanabe Y., Kuratsune H. A potential biomarker for fatigue: Oxidative stress and anti-oxidative activity. Biol Psychol. 2016; 118(1):88-93.
  15. Chen W., Jia Z, Pan M.H., Anandh Babu P.V. Natural Products for the Prevention of Oxidative Stress-Related Diseases: Mechanisms and Strategies. Oxid Med Cell Longev. 2016; 2016 4628502.
  16. Zha Z., Liu S., Liu Y., Li C., Wang L. Potential Utility of Natural Products against Oxidative Stress in Animal Models of Multiple Sclerosis. Antioxidants (Basel). 2022; 11(8):1495.
  17. Ruhee R.T., Suzuki K. The Integrative Role of Sulforaphane in Preventing Inflammation, Oxidative Stress and Fatigue: A Review of a Potential Protective Phytochemical. Antioxidants. 2020;9(6):521.
  18. Jamnani M.J., Holmelid B., Vedeler A., Parsian H.H., Andersen H.L., Fossen T. Natural Products from Leaves of the Ancient Iranian Medicinal Plant Echium amoenum Fisch. & C. A. Mey. Molecules. 2023; 28 (1): 385.
  19. Jafari H., Mokaberinejad R., Raeis-Abdollahi E. Echium amoenum from viewpoint of Avicenna: a brief review. J Contemp Med. Sci. 2018; 4 (4): 187–190.
  20. Zannou O., Pashazadeh H., Ghellam M., Ibrahim S.A., Koca I. Extraction of Anthocyanins from Borage (Echium amoenum) Flowers Using Choline Chloride and a Glycerol-Based, Deep Eutectic Solvent: Optimization, Antioxidant Activity, and In Vitro Bioavailability. Molecules. 2021;27(1): 134.
  21. Cartwright A.C. The British pharmacopoeia. 7th ed. London: The Stationary Office; 2013.
  22. National Research Council Committee for the Update of the Guide for the C, Use of Laboratory A. The National Academies Collection: Reports funded by National Institutes of Health. Guide for the Care and Use of Laboratory Animals. Washington (DC): National Academies Press. (US); 2011.
  23. Yadollahi H, Safaeinejad F, Hajimehdipoor H, Mousavi Z, Ara L, Esmaeili S. Anti-Fatigue Effect of Viola odorata L. in Forced Swimming Test in Rat. Trad. Integ. Med. 2023; 8 (1): 164-169.
  24. Naviaux R.K., Naviaux J.C., Li K., Bright A.T., Alaynick W.A., Wang L., Baxter A., Nathan N., Anderson W., Gordon E. Metabolic features of chronic fatigue syndrome. Proc. Natl. Acad. Sci. USA. 2016; 113(37): E5472-5480.
  25. Hody S., Rogister B., Leprince P., Wang F., Croisier J.L. Muscle fatigue experienced during maximal eccentric exercise is predictive of the plasma creatine kinase (CK) response. Scand. J. Med. Sci. Sports. 2013; 23 (4): 501-507.
  26. Neame M.T., Wright D., Chandrasekaran S. Persisting fatigue and myalgia as the presenting features in a case of hypokalaemic periodic paralysis. BMJ Case Rep. 2017; 2017 2017219991.
  27. Kiba N. ENZYMES | Enzymes in Physiological Samples. In: Worsfold P, Townshend A, Poole C, eds. Encyclopedia of Analytical Sci. (Second Edition). Oxford: Elsevier; 2005:536-544.
  28. Sadeghi L., Yousefi Babadi V., Tanwir F. Improving effects of Echium amoenum aqueous extract on rat model of Alzheimer's disease. J. Integr. Neurosci. 2018;17(3-4): 661-669.
  29. Rabiei Z., Setorki M. Effect of hydroalcoholic Echium amoenum extract on scopolamine-induced learning and memory impairment in rats. Pharm. Biol. 2018; 56 (1): 672-677.
  30. Sadeghi L., Tanwir F., Yousefi Babadi V. Physiological and Biochemical Effects of Echium Amoenum Extract on Mn (2+)-Imposed Parkinson Like Disorder in Rats. Adv. Pharm. Bull. 2018;8(4):705-713.
  31. Nouri M., Farajdokht F., Torbati M., Ranjbar F., Hamedyazdan S., Araj-Khodaei M., Sadigh-Eteghad S. A Close Look at Echium amoenum Processing, Neuroactive Components, and Effects on Neuropsychiatric Disorders. Galen Med J. 2019;8(2019): e1559.
آمار
تعداد مشاهده مقاله: 421
تعداد دریافت فایل اصل مقاله: 360


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب