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Hosseinzadeh, Mohammad Hossein, Mortazavi, Parham, Hashemi, Zahra, Arab, Amirhosein, Eghbali, Mohammad, Ebrahimzadeh, Mohammad Ali. (1402). The role of Rosa damascena Mill. on acute hypoxia. سامانه مدیریت نشریات علمی, 2(1), 60-67. doi: 10.22092/jncc.2023.129601
Mohammad Hossein Hosseinzadeh; Parham Mortazavi; Zahra Hashemi; Amirhosein Arab; Mohammad Eghbali; Mohammad Ali Ebrahimzadeh. "The role of Rosa damascena Mill. on acute hypoxia". سامانه مدیریت نشریات علمی, 2, 1, 1402, 60-67. doi: 10.22092/jncc.2023.129601
Hosseinzadeh, Mohammad Hossein, Mortazavi, Parham, Hashemi, Zahra, Arab, Amirhosein, Eghbali, Mohammad, Ebrahimzadeh, Mohammad Ali. (1402). 'The role of Rosa damascena Mill. on acute hypoxia', سامانه مدیریت نشریات علمی, 2(1), pp. 60-67. doi: 10.22092/jncc.2023.129601
Hosseinzadeh, Mohammad Hossein, Mortazavi, Parham, Hashemi, Zahra, Arab, Amirhosein, Eghbali, Mohammad, Ebrahimzadeh, Mohammad Ali. The role of Rosa damascena Mill. on acute hypoxia. سامانه مدیریت نشریات علمی, 1402; 2(1): 60-67. doi: 10.22092/jncc.2023.129601

The role of Rosa damascena Mill. on acute hypoxia

Natural Compounds Chemistry
دوره 2، شماره 1، دی 2023، صفحه 60-67    اصل مقاله (538.82 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22092/jncc.2023.129601
نویسندگان
Mohammad Hossein Hosseinzadeh* 1؛ Parham Mortazavi2؛ Zahra Hashemi3؛ Amirhosein Arab4؛ Mohammad Eghbali3؛ Mohammad Ali Ebrahimzadeh3
1Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
2Student Research Committee, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
3Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
4Student Research Committee and Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
چکیده
Background: In the Rosaceae family, Rosa damascene Mill. is an important medicinal plant. Studies reported its antioxidant, cardioprotective, and neuroprotective effects that may be related to the anti-hypoxic activity. So, we investigated the anti-hypoxic effects of R. damascenaare in this study to evaluate the possible mechanism of plant effectiveness in cardiovascular and neurological disease.
Methods: The R. damascenaare flowers were extracted with methanol by maceration method and anti-hypoxic activities were evaluated in haemic, asphyctic, and circulatory models.
Results: In asphyctic hypoxia, extract at 250 mg/kg increased the survival time to 21.53±1.21 minutes, which was significantly lower (P<0.0001) than phenytoin (29.60±1.34 minutes). In haemic hypoxia, extract effects were similar to propranolol (P>0.05) at 125, and 250 mg/kg (15.85±0.69 and 16.19±1.71 vs. 16.44±1.39 minutes, P>0.05). In circulatory hypoxia, extract significantly increased the survival time at 250 mg/kg compared to the negative control (13.64±1.51 vs. 9.79±0.56 minutes, P<0.01) but its effect was weaker than propranolol (16.44±1.39 minutes).
Conclusion: R. damascenaare show potent anti-hypoxic activity in the haemic model. Its effects were significant in higher doses in asphyctic and circulatory models.
کلیدواژه‌ها
Cardiovascular Diseases؛ Reactive Oxygen Species؛ Asphyxia؛ Ischemia؛ Stroke
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