اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,038
تعداد مقالات33,991
تعداد مشاهده مقاله45,938,516
تعداد دریافت فایل اصل مقاله77,248,441
Alimoradi, Zainab, Taghian, Farzaneh, Jalali Dehkordi, Khosro. (1403). Effect of Linalool, Cineole, and β-Bourbonene Coupled with Aerobic Training on the Improvement of Presenilin-1/Amyloid Protein Precursor/Interleukin-1 beta/CASPASE 1 Network, Oxidative Capacity, and miRNA-210 in Mice with Alzheimer's Disease. سامانه مدیریت نشریات علمی, 79(3), 629-638. doi: 10.32592/ARI.2024.79.3.629
Zainab Alimoradi; Farzaneh Taghian; Khosro Jalali Dehkordi. "Effect of Linalool, Cineole, and β-Bourbonene Coupled with Aerobic Training on the Improvement of Presenilin-1/Amyloid Protein Precursor/Interleukin-1 beta/CASPASE 1 Network, Oxidative Capacity, and miRNA-210 in Mice with Alzheimer's Disease". سامانه مدیریت نشریات علمی, 79, 3, 1403, 629-638. doi: 10.32592/ARI.2024.79.3.629
Alimoradi, Zainab, Taghian, Farzaneh, Jalali Dehkordi, Khosro. (1403). 'Effect of Linalool, Cineole, and β-Bourbonene Coupled with Aerobic Training on the Improvement of Presenilin-1/Amyloid Protein Precursor/Interleukin-1 beta/CASPASE 1 Network, Oxidative Capacity, and miRNA-210 in Mice with Alzheimer's Disease', سامانه مدیریت نشریات علمی, 79(3), pp. 629-638. doi: 10.32592/ARI.2024.79.3.629
Alimoradi, Zainab, Taghian, Farzaneh, Jalali Dehkordi, Khosro. Effect of Linalool, Cineole, and β-Bourbonene Coupled with Aerobic Training on the Improvement of Presenilin-1/Amyloid Protein Precursor/Interleukin-1 beta/CASPASE 1 Network, Oxidative Capacity, and miRNA-210 in Mice with Alzheimer's Disease. سامانه مدیریت نشریات علمی, 1403; 79(3): 629-638. doi: 10.32592/ARI.2024.79.3.629

Effect of Linalool, Cineole, and β-Bourbonene Coupled with Aerobic Training on the Improvement of Presenilin-1/Amyloid Protein Precursor/Interleukin-1 beta/CASPASE 1 Network, Oxidative Capacity, and miRNA-210 in Mice with Alzheimer's Disease

Archives of Razi Institute
مقاله 24، دوره 79، شماره 3، مرداد و شهریور 2024، صفحه 629-638    اصل مقاله (753.37 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2024.79.3.629
نویسندگان
Zainab Alimoradi1؛ Farzaneh Taghian* 2؛ Khosro Jalali Dehkordi3
1Ph.D. student, Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
2Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
3Assistant professor, Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
چکیده
Alzheimer's is an advanced nervous disorder related to aging. This research aims to determine the effect of eight weeks of aerobic training and linalool, cineole, and β-Bourbonene on preventing and improving Alzheimer's disease. Mice randomly divided into 8 groups: Control group, Mice induced Alzheimer's disease treating with β-amyloid (Alzheimer group), Alzheimer's mice were treated with bioactive compounds of herbal medicine (Linalool with a concentration of 25 mg/kg, Cineol with a concentration of 100 mg/kg, β-Bourbonene with a concentration of 0.20 μg by gavage for 8 weeks, Alzheimer+Biocompounds group), Alzheimer's mice treated with aerobic exercise with a moderate intensity treadmill for 8 weeks (Alzheimer's+Training group), Alzheimer's mice treated with bioactive compounds of herbal medicine and aerobic exercise for 8 weeks (Alzheimer+Biocompounds+Training group), Healthy mice were first treated with the bioactive compounds of the herbal medicine, and then were induced with Alzheimer's (Biocompounds+Alzheimer group), Healthy mice were first treated with aerobic exercise using a treadmill with moderate intensity for 8 weeks and then induced Alzheimer's disease (Training+Alzheimer group), Healthy mice were first treated with the bioactive compounds of the herbal medicine and aerobic exercise for 8 weeks and then induced Alzheimer's disease (Biocompounds+Training+Alzheimer group). Compared to other groups, the IL1β/CASP3/PSEN1/APP level improved in mice first treated with aerobic exercise and biocompounds. Oxidative capacity was improved by exercise training and bioactive compounds. In addition, exercise training and bioactive compounds regulated the miRNA-210 in the hippocampus of the mice with Alzheimer's. We could conclude that consuming biocompounds and aerobic training can manage and prevent Alzheimer's.
کلیدواژه‌ها
Alzheimer؛ aerobic exercise؛ herbal compounds؛ Biocompounds
عنوان مقاله [English]
تاثیر لینالول، سینائول، بتا بوربونین همراه با تمرین هوازی سبب بهبود شبکه‌های PSEN1/APP/IL1β/CASP3، ظرفیت اکسیداتیو و miRNA-210 را در موش‌های مبتلا به بیماری آلزایمر.
چکیده [English]
آلزایمر یک اختلال عصبی پیشرفته مرتبط با افزایش سن است. این تحقیق با هدف تعیین تأثیر هشت هفته تمرین هوازی و مصرف لینالول، سینائول، بتا بوربونین بر پیشگیری و بهبود بیماری آلزایمر انجام شد. موش‌ها به‌طور تصادفی به 8 گروه تقسیم شدند: گروه کنترل، موش‌های آلزایمر تحت درمان با بتا آمیلوئید (گروه Alzheimer)، موش‌های آلزایمر با ترکیبات زیست فعال داروی گیاهی (لینالول با غلظت 25 میلی‌گرم بر کیلوگرم، سینائول با غلظت 100 میلی گرم بر کیلوگرم و بتا بوربونن با غلظت 0.2 میکروگرم به صورت گاواژ به مدت 8 هفته، گروه Alzheimer+Biocompounds)، موش های آلزایمر تحت درمان با ورزش هوازی با تردمیل با شدت متوسط به مدت 8 هفته) گروه Alzheimer's+Training )، موش های آلزایمر تحت درمان با ترکیبات زیست فعال داروی گیاهی و ورزش هوازی به مدت 8 هفته (گروه Alzheimer+Biocompounds+Training)، موش های سالم ابتدا با ترکیبات زیست فعال داروی گیاهی تحت درمان قرار گرفتند و سپس آلزایمر القا شدند (گروه Biocompounds+Alzheimer)، موش های سالم ابتدا با استفاده از تردمیل با شدت متوسط به مدت 8 هفته تحت درمان با ورزش هوازی قرار گرفتند و سپس به بیماری آلزایمر القاء شدند (گروه Training+Alzheimer)، موش های سالم ابتدا با ترکیبات زیست فعال داروی گیاهی و ورزش هوازی تحت درمان قرار گرفتند (گروه Biocompounds+Training+Alzheimer). سطح L1β/CASP3/PSEN1/APP در موش‌هایی که ابتدا با ورزش هوازی و ترکیبات زیستی تحت درمان قرار گرفتند در مقایسه با سایر گروه‌ها بهبود یافت. ظرفیت اکسیداتیو با تمرینات ورزشی و ترکیبات زیست فعال بهبود یافت. علاوه بر این، تمرینات ورزشی و ترکیبات زیست فعال، miRNA-210 را در هیپوکامپ موش‌های مبتلا به آلزایمر تنظیم کردند. می توان نتیجه گرفت که مصرف ترکیبات زیستی و تمرینات هوازی می تواند آلزایمر را مدیریت و از آن پیشگیری کند.
کلیدواژه‌ها [English]
آلزایمر, ورزش هوازی, ترکیبات گیاهی, ترکیبات زیستی
سایر فایل های مرتبط با مقاله
مراجع
  1. Ogrodnik M, Salmonowicz H, Gladyshev VN. Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells. Aging cell. 2019;18(1):e12841.
  2. Foreman J. Exercise is Medicine: How Physical Activity Boosts Health and Slows Aging: Oxford University Press; 2019.
  3. Sommerlad A, Perera G, Singh-Manoux A, Lewis G, Stewart R, Livingston G. Accuracy of general hospital dementia diagnoses in England: sensitivity, specificity, and predictors of diagnostic accuracy 2008–2016. Alzheimer's & Dementia. 2018;14(7):933-43.
  4. Anand R, Gill KD, Mahdi AA. Therapeutics of Alzheimer's disease: Past, present and future. Neuropharmacology. 2014;76:27-50.
  5. Knopman DS, Amieva H, Petersen RC, Chételat G, Holtzman DM, Hyman BT, et al. Alzheimer disease. Nature reviews Disease primers. 2021;7(1):33.
  6. Hajibabaie F, Abedpoor N, Taghian F, Safavi K. A cocktail of polyherbal bioactive compounds and regular mobility training as senolytic approaches in age-dependent alzheimer’s: the in silico analysis, lifestyle intervention in old age. Journal of Molecular Neuroscience. 2023;73(2-3):171-84.
  7. Liang Y-J, Su Q-W, Sheng Z-R, Weng Q-Y, Niu Y-F, Zhou H-D, et al. Effectiveness of physical activity interventions on cognition, neuropsychiatric symptoms, and quality of life of Alzheimer’s disease: An update of a systematic review and meta-analysis. Frontiers in aging neuroscience. 2022;14:155.
  8. Kivimäki M, Singh-Manoux A, Pentti J, Sabia S, Nyberg ST, Alfredsson L, et al. Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis. bmj. 2019;365.
  9. Lubitz I, Ricny J, Atrakchi‐Baranes D, Shemesh C, Kravitz E, Liraz‐Zaltsman S, et al. High dietary advanced glycation end products are associated with poorer spatial learning and accelerated Aβ deposition in an Alzheimer mouse model. Aging Cell. 2016;15(2):309-16.
  10. Delagarza VW. Pharmacologic treatment of Alzheimer's disease: an update. American Family Physician. 2003;68(7):1365-73.
  11. Sabogal-Guáqueta AM, Osorio E, Cardona-Gómez GP. Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer's mice. Neuropharmacology. 2016;102:111-20.
  12. Hajibabaie F, Abedpoor N, Javanmard SH, Hasan A, Sharifi M, Rahimmanesh I, et al. The molecular perspective on the development of melanoma and genome engineering of T-cells in targeting therapy. Environmental Research. 2023:116980.
  13. Li W-y, Gao J-y, Lin S-Y, Pan S-t, Xiao B, Ma Y-t, et al. Effects of involuntary and voluntary exercise in combination with Acousto-optic stimulation on adult neurogenesis in an Alzheimer's mouse model. Molecular Neurobiology. 2022;59(5):3254-79.
  14. Xiang S, Liu F, Lin J, Chen H, Huang C, Chen L, et al. Fucoxanthin inhibits β-amyloid assembly and attenuates β-amyloid oligomer-induced cognitive impairments. Journal of agricultural and food chemistry. 2017;65(20):4092-102.
  15. Abedpoor N, Taghian F, Ghaedi K, Niktab I, Safaeinejad Z, Rabiee F, et al. PPARγ/Pgc-1α-Fndc5 pathway up-regulation in gastrocnemius and heart muscle of exercised, branched chain amino acid diet fed mice. Nutrition & metabolism. 2018;15(1):1-15.
  16. Santos ECd, Silva LS, Pinheiro AS, Teixeira DE, Peruchetti DB, Silva-Aguiar RP, et al. The monoterpene 1, 8-cineole prevents cerebral edema in a murine model of severe malaria. Plos one. 2022;17(5):e0268347.
  17. Liu S, Fan M, Zheng Q, Hao S, Yang L, Xia Q, et al. MicroRNAs in Alzheimer's disease: Potential diagnostic markers and therapeutic targets. Biomedicine & Pharmacotherapy. 2022;148:112681.
  18. Ren Z, Yu J, Wu Z, Si W, Li X, Liu Y, et al. MicroRNA-210-5p contributes to cognitive impairment in early vascular dementia rat model through targeting Snap25. Frontiers in Molecular Neuroscience. 2018;11:388.
  19. Nunomura A, Perry G. RNA and oxidative stress in Alzheimer’s disease: focus on microRNAs. Oxidative medicine and cellular longevity. 2020;2020.
  20. Ramakrishna S, Muddashetty RS. Emerging role of microRNAs in dementia. Journal of molecular biology. 2019;431(9):1743-62.
  21. Smith PY, Hernandez-Rapp J, Jolivette F, Lecours C, Bisht K, Goupil C, et al. miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo. Human molecular genetics. 2015;24(23):6721-35.
  22. Li Y, Zhang T, Zhou Y, Sun Y, Cao Y, Chang X, et al. A Presenilin/Notch1 pathway regulated by miR-375, miR-30a, and miR-34a mediates glucotoxicity induced-pancreatic beta cell apoptosis. Scientific reports. 2016;6(1):36136.
  23. Hajibabaie F, Kouhpayeh S, Mirian M, Rahimmanesh I, Boshtam M, Sadeghian L, et al. MicroRNAs as the actors in the atherosclerosis scenario. Journal of physiology and biochemistry. 2020;76:1-12.
  24. Hajibabaie F, Abedpoor N, Assareh N, Tabatabaiefar MA, Shariati L, Zarrabi A. The importance of SNPs at miRNA binding sites as biomarkers of gastric and colorectal cancers: a systematic review. Journal of Personalized Medicine. 2022;12(3):456.
  25. Watts M, Williams G, Lu J, Nithianantharajah J, Claudianos C. MicroRNA-210 Knockout Alters Dendritic Density and Behavioural Flexibility. bioRxiv. 2019:762450.
  26. Siedlecki-Wullich D, Català-Solsona J, Fábregas C, Hernández I, Clarimon J, Lleó A, et al. Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer’s disease. Alzheimer's research & therapy. 2019;11:1-11.
  27. Khan A, Vaibhav K, Javed H, Tabassum R, Ahmed ME, Khan MM, et al. 1, 8-cineole (eucalyptol) mitigates inflammation in amyloid Beta toxicated PC12 cells: relevance to Alzheimer’s disease. Neurochemical research. 2014;39:344-52.
آمار
تعداد مشاهده مقاله: 11,848
تعداد دریافت فایل اصل مقاله: 608


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب