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Jadgalradeh, Abdolhakim, Iqbal, Mudassar. (1403). Antinociceptive and anti-inflammatory activities of Ferula elaeochytris Korovin methanolic extract in rat model. سامانه مدیریت نشریات علمی, 79(3), 645-650. doi: 10.32592/ARI.2024.79.3.645
Abdolhakim Jadgalradeh; Mudassar Iqbal. "Antinociceptive and anti-inflammatory activities of Ferula elaeochytris Korovin methanolic extract in rat model". سامانه مدیریت نشریات علمی, 79, 3, 1403, 645-650. doi: 10.32592/ARI.2024.79.3.645
Jadgalradeh, Abdolhakim, Iqbal, Mudassar. (1403). 'Antinociceptive and anti-inflammatory activities of Ferula elaeochytris Korovin methanolic extract in rat model', سامانه مدیریت نشریات علمی, 79(3), pp. 645-650. doi: 10.32592/ARI.2024.79.3.645
Jadgalradeh, Abdolhakim, Iqbal, Mudassar. Antinociceptive and anti-inflammatory activities of Ferula elaeochytris Korovin methanolic extract in rat model. سامانه مدیریت نشریات علمی, 1403; 79(3): 645-650. doi: 10.32592/ARI.2024.79.3.645

Antinociceptive and anti-inflammatory activities of Ferula elaeochytris Korovin methanolic extract in rat model

Archives of Razi Institute
مقاله 26، دوره 79، شماره 3، مرداد و شهریور 2024، صفحه 645-650    اصل مقاله (343.25 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2024.79.3.645
نویسندگان
Abdolhakim Jadgalradeh* ؛ Mudassar Iqbal
Department of Pharmacy Practice, Faculty of Pharmacy, University of Sindh Jamshoro, Pakistan
چکیده
Today, the current chemical agents for pain control have relatively many complications. They are associated with the occurrence of disorders in the digestive system, kidney damage, or addiction, which has caused people to find newer drugs that, in addition to removing side effects, are cheap and available. The present in vivo survey aimed to assess the antinociceptive and anti-inflammatory activity of Ferula elaeochytris Korovin methanolic extract (FEME) in male Swiss mice. After obtaining the methanolic extract through the maceration process, the antinociceptive efficacy of FEME at doses of 25 to 100 mg/kg was assessed by the tail-flick, hot-plate, and formalin tests. In addition, anti-inflammatory evaluation was performed by the Carrageenan-induced paw edema model. We found that in the tail-flick and hot plate test, FEME mainly at the dose of 100 mg/kg significantly reduced the latency time as well as better the time of the observance of licking or jumping in comparison with normal saline (P<0.001). We reported that FEME at 50, and 100 mg/kg considerably declined the pain behaviors in the acute and chronic phase in comparison with normal saline (p<0.001). FEME markedly (p < 0.05) declined paw edema in a dose- and time-dependent response, so a significant difference was observed in paw edema followed by treatment with FEME at 50 and 100 mg/kg (p<0.001). To conclude, this study reported the potent analgesic and inflammatory effects of F. elaeochytris methanolic extract to control peripheral and central pain. However, additional experiments are mandatory to clear the accurate mechanisms of action of this plant.
کلیدواژه‌ها
analgesic؛ inflammation؛ natural products؛ in vivo؛ pain
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مراجع
  1. Lamont LA, Tranquilli WJ, Grimm KA. Physiology of pain. Vet Clin North Am Small Anim Pract. 2000; 30(4): 703–728.
  2. Abdulkhaleq LA, Assi MA, Abdullah R, Zamri-Saad M, Taufiq-Yap YH, Hezmee MN. The crucial roles of inflammatory mediators in inflammation: A review. Veterinary world. 2018;11(5):627.
  3. Ahmed AU. An overview of inflammation: mechanism and consequences. Frontiers in Biology. 2011;6(4):274-81.
  4. Khodabakhshi Rad, A., Kazemi Mehrjerdi, H., Pedram, M. S., Azizzadeh, M., Amanollahi, S. Clinical Evaluation of the Effect of Methylprednisolone Sodium Succinate and Meloxicam in Experimental Acute Spinal Cord Injury. Iranian Journal of Veterinary Medicine, 2023;17(2):129-138.
  5. Nikjooy, N., Asghari, A., Hassanpour, S., Arfaee, F. Study of Antinociceptive Role of the Manna of Hedysarum and the Neurotransmitter Systems Involved in Mice. Iranian Journal of Veterinary Medicine, 2022;16(3):265-273.
  6. Gagnier JJ, van Tulder MW, Berman B, Bombardier C. Herbal medicine for low back pain: a Cochrane review. Spine. 2007;32(1):82–92.
  7. Mohammadhosseini M, Venditti A, Sarker SD, Nahar L, Akbarzadeh A. The genus Ferula: Ethnobotany, phytochemistry and bioactivities–A review. Industrial crops and products. 2019;129:350-94.
  8. Salehi M, Naghavi MR, Bahmankar M. A review of Ferula species: Biochemical characteristics, pharmaceutical and industrial applications, and suggestions for biotechnologists. Industrial Crops and Products. 2019;139:111511.
  9. Sahebkar A, Iranshahi M. Volatile constituents of the genus Ferula (Apiaceae): A review. Journal of Essential Oil Bearing Plants. 2011;14(5):504-31.
  10. Bagheri SM, Shieh A, Ghalenoei JA, Yadegari M, Alborzi N. Review of potential spermatogenic and aphrodisiac effects of the Ferula genus. Clinical and Experimental Reproductive Medicine. 2023;50(3):143.
  11. Mahmoudvand H, Sepahvand P, Jahanbakhsh S, Azadpour M. Evaluation of the antileishmanial and cytotoxic effects of various extracts of garlic (Allium sativum) on Leishmania tropica. Journal of Parasitic Diseases. 2016;40:423-6.
  12. Jahanbakhsh S, Azadpour M, Tavakoli Kareshk A, Keyhani A, Mahmoudvand H. Zataria multiflora Bioss: lethal effects of methanolic extract against protoscoleces of Echinococcus granulosus. Journal of parasitic diseases. 2016;40:1289-92.
  13. Evans WC. Trease and Evans pharmacognosy. 14th ed. London: WB Saunders Company Limited, 1972.
  14. Mahmoudvand H, Khaksarian M, Ebrahimi K, Shiravand S, Jahanbakhsh S, Niazi M, Nadri S. Antinociceptive effects of green synthesized copper nanoparticles alone or in combination with morphine. Annals of Medicine and Surgery. 2020;51:31-6.
  15. Ghasemian Yadegari J, Fazeli Moghadam E, Golmohammadi H, Dastyarhaghighi S, Ghoulami M, Mahmoudvand H. Effect of oral administration of Astragalus ecbatanus chloroform extract on acute and chronic pain in Balb/C mice. Research Journal of Pharmacognosy. 2023.
  16. Mahmoudvand H, Ziaali N, Ghazvini H, Shojaee S, Keshavarz H, Esmaeilpour K, Sheibani V. Toxoplasma gondii infection promotes neuroinflammation through cytokine networks and induced hyperalgesia in BALB/c mice. Inflammation. 2016;39:405-12.
  17. Medeiros MA, Gama e Silva M, de Menezes Barbosa J, Martins de Lavor É, Ribeiro TF, Macedo CA, de Souza Duarte-Filho LA, Feitosa TA, de Jesus Silva J, Fokoue HH, Araújo CR. Antinociceptive and anti-inflammatory effects of hydrazone derivatives and their possible mechanism of action in mice. Plos one. 2021;16(11):e0258094.
  18. Nadri S, Mahmoudvand H, Mahmoudvand H, Rashnoo M, Khaksarian M. Chemical composition, antinociceptive and acute toxicity of Pistacia atlantica fruit extract. Entomol Appl Sci Letters. 2018;5(3):8-12.
  19. Carlisson KH, Jurna I. Depression by flupirtine; a novel analgesic agent of motor and sensory response of nociceptive system in the rat spinal cord. Eur J Pharmacol. 1987;143(1): 87–99.
  20. Dubisson D, Dennis SG. The formalin test a quantivie study of the analgesic effects of morphin, meperidne and brainstem stimulation in rat and cats. Pain. 1997;4(2):161–174.
  21. Chen CL, Broom DC, Liu Y, Denooji JC, Li Z, Cen C, Abdel Samad O, Jessell TM, Woolf CJ, Ma Q. Run x1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron. 2006; 49(3):365–377.
  22. Tgolsen A, Berge OG, Hunskaar S, Rosland JH, Hole K. The formalin test: an evaluation of the method. Pain. 1991; 51(1):17–25.
  23. Manabu S, Tsuyako O, Hiroshi T, Reizo I. Modified formalin test: characteristic biphasic pain response. Pain. 1989;38(3):347–352.
  24. Souza MA, Scapinello J, Guzatti JG, Scatolin M, Martello R, Schindler MS, Calisto JF, Alves B, Morgan LV, Oliveira JV, Dal Magro J. Antinociceptive effect and mechanism of supercritical carbon dioxide extract of Aloysia gratissima leaves in mice. biomedical journal. 2021;44(6):S63-72.
  25. Verri Jr WA, Vicentini FT, Baracat MM, Georgetti SR, Cardoso RD, Cunha TM, Ferreira SH, Cunha FQ, Fonseca MJ, Casagrande R. Flavonoids as anti-inflammatory and analgesic drugs: mechanisms of action and perspectives in the development of pharmaceutical forms. Studies in natural products chemistry. 2012;36:297-330.
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