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Cajuday, Lilibeth, Malaluan, Ivane, Morano, Phil, Serrano, Jocelyn, Imperial, Jazzlyn. (1403). Antihypertensive and Antiobesity Activities of Selected Plants from Albay and Sorsogon Philippines. سامانه مدیریت نشریات علمی, 13(Special), 863-869. doi: 10.22034/jmpb.2024.364241.1631
Lilibeth Ase Cajuday; Ivane N Malaluan; Phil V Morano; Jocelyn E Serrano; Jazzlyn T Imperial. "Antihypertensive and Antiobesity Activities of Selected Plants from Albay and Sorsogon Philippines". سامانه مدیریت نشریات علمی, 13, Special, 1403, 863-869. doi: 10.22034/jmpb.2024.364241.1631
Cajuday, Lilibeth, Malaluan, Ivane, Morano, Phil, Serrano, Jocelyn, Imperial, Jazzlyn. (1403). 'Antihypertensive and Antiobesity Activities of Selected Plants from Albay and Sorsogon Philippines', سامانه مدیریت نشریات علمی, 13(Special), pp. 863-869. doi: 10.22034/jmpb.2024.364241.1631
Cajuday, Lilibeth, Malaluan, Ivane, Morano, Phil, Serrano, Jocelyn, Imperial, Jazzlyn. Antihypertensive and Antiobesity Activities of Selected Plants from Albay and Sorsogon Philippines. سامانه مدیریت نشریات علمی, 1403; 13(Special): 863-869. doi: 10.22034/jmpb.2024.364241.1631

Antihypertensive and Antiobesity Activities of Selected Plants from Albay and Sorsogon Philippines

Journal of Medicinal plants and By-products
مقاله 15، دوره 13، Special، بهمن 2024، صفحه 863-869    اصل مقاله (562.18 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2024.364241.1631
نویسندگان
Lilibeth Ase Cajuday* 1؛ Ivane N Malaluan2؛ Phil V Morano1؛ Jocelyn E Serrano1؛ Jazzlyn T Imperial1
1Biology Department, College of Science Bicol University, Albay 4500 Philippines
2Chemistry Department, College of Science Bicol University, Albay 4500 Philippines
چکیده
The present study evaluated the antihypertensive and antiobesity activities of twenty-three (23) selected plants from biodiverse sites in Albay and Sorsogon Philippines. In vitro antihypertensive and antiobesity activities of the plant extracts were screened using angiotensin-1 converting enzyme (ACE) and porcine pancreatic lipase (PPL) inhibition assays. The safety of the bioactive extracts was also evaluated using organ-specific toxicity assays. A total of five plants were potent ACE inhibitors (>70%) at 100 ppm concentration. The IC50 values of the bioactive extracts (50.77 to 67.94 ug/ml) were comparable to the potent drug Captopril (53.35 ug/ml). Seven plants were active against the PPL enzyme at 100 ppm concentration. Three plants exhibited strong PPL inhibitory activity (>70) with IC50 values of 46.1 to 53.45 ug/ml, less than half the value computed for Orlistat (96.04 ug/ml), indicative of its strong potential as an antiobesity agent. Cytotoxicity results revealed that all the bioactive plant extracts were non-toxic and safe.  The study's findings are very promising in the search for potential herbal drugs against hypertension and obesity from natural sources in the region.
کلیدواژه‌ها
ACE activity؛ Pancreatic lipase؛ CVDs؛ Herbal drug
مراجع
  1. World Health Organization. Cardiovascular diseases. 2021. https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(vcds).
  2. Sales C., Lin B., Palaniappan L. Philippine and Philippine-American Health Statistics, 1994-2018. Center for Asian Health Research and Education Data Brief 1. 2020.
  3. Sison J., Divinagracia R., Nailes J. Asian management of hypertension: Current status, home blood pressure, and specific concerns in Philippines (a country report). Journal of clinical hypertension (Greenwich, Conn.). 2020; 22(3): 504–507.
  4. Gutierrez M.M., Sakulbumrungsil R. Factors associated with medication adherence of hypertensive patients in the Philippines: A systematic review. J Clin Hypertens. 2021; 27(19).
  5. World Health Organization. Fact Sheets: Obesity and overweight. 2013. http://www.who.int/mediacentre /factsheets /fs311/en/index.html.
  6. World Health Organization. Obesity and Overweight. 2020. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
  7. Gumaru, M. Overweight and obesity is top nutrition concern in 8 Metro Manila cities-FNRI survey. FNRI Website. n.d. https://www.fnri.dost.gov.ph/index.php/programs-and-projects/news-and-announcement/769-overweight-and-obesity-is-top-nutrition-concern-in-8-metro-manila-cities-fnri-survey
  8. Yun J.W. Possible antiobesity therapeutics from nature: A review. Phytochem. 2011; 71: 1625–41.
  9. Marrelli M., Loizzo M.R., Nicoletti M., Menichini F., Conforti F. Inhibition of key enzymes linked to obesity by preparations from Mediterranean dietary plants: effects on α-amylase and pancreatic lipase activities. Plant Foods Hum Nutr. 2013; 68(4): 340–46.
  10. Liu T.T., Liu X.T., Chen Q.X., Shi Y. Lipase inhibitors for obesity: A review. Biomedicine & Pharmacotherapy. 2020; 128: 110314.
  11. Ahmad I., Yanuar A., Mulia K., Mun’im A. Review of angiotensin-converting enzyme inhibitory assay: Rapid method in drug discovery of herbal plants. Pharcamacogn Rev. 2017; 11(21): 1–7.
  12. Handa C.L., Zhang Y., Kumari S., Xu J., Ida E. I., Chang S.K.C. Comparative study of angiotensin I-converting enzyme (ACE) inhibition of soy foods as affected by processing methods and protein isolation. Processes. 2020; 8(8):978. http://dx.doi.org/10.3390/pr8080978
  13. Buot I. An ethnobotanical study of plant biodiversity of Mt. Mayon, Bicol Peninsula, Albay Philippines. JNS. 2009; 8(1): 1–10.
  14. [UNESCO] United Nations Educational, Scientific and Cultural Organization. Mayon Volcano Natural Park. 2015. https://whc.unesco.org/en/tentativelists/6007/.
  15. Key Biodiversity Areas Partnership. Key Biodiversity Areas factsheet: Bulusan Volcano Natural Park. In: World Database of Key Biodiversity Areas. Key Biodiversity Areas Partnership: BirdLife International, IUCN, American Bird Conservancy, Amphibian Survival Alliance, Conservation International, Critical Ecosystem Partnership Fund, Global Environment Facility, Re:wild, NatureServe, Rainforest Trust, Royal Society for the Protection of Birds, World Wildlife Fund and Wildlife Conservation Society. 2023.
  16. Quisumbing E. Medicinal Plants of the Philippines. Manila, Katha Publishing. 1978;1262.
  17. Tutor J., Hernandez C. Fluorescence-based angiotensin-converting enzyme (ACE) inhibition assay. In: Tuklas Lunas Protocols for Drug Discovery and Development Manual 2B: Primary Bioactivity Assays. Taguig City: Philippine Council for Health Res Development. 2019; 90–113.
  18. Allanigue E.J., Perez Y.P., Tutor J., Hernandez C. Lipase inhibition assay. Αlpha-glucosidase inhibition assay. In: Tuklas Lunas Protocols for Drug Discovery and Development Manual 2B: Primary Bioactivity Assays. Taguig City: Philippine Council for Health Research and Development. 2019;72–87.
  19. Joseph R.C. Re: How can I calculate the IC50 value from the percent inhibition graph for antioxidant activity? 2022. https://www.researchgate.net/post/How_can_I_calculate_IC50_ value_from_percent_inhibition_graph_for_antioxidant_activity4/61f3a772b837ba6eaa3ea777/citation/download.
  20. Consolini A.E., Baldini O.A., Amat A.G. Pharmacological basis for the empirical use of Eugenia uniflora L. (Myrtaceae) as antihypertensive. J Ethnopharmacol. 1999; 66(1): 33–39.
  21. Vechi G., De Souza P., Da Silva L.M., De Andrade S.F., Filho V.C., Da Silva R.C.M.V.A.F. Mechanisms underlying Eugenia mattosii D. legrand leaves extract, fractions, and compounds induce relaxation of the aorta in normotensive and hypertensive rats. 3 Biotech. 2019; 9(12), 445.
  22. Ribeiro R.M., Pinheiro N.V.F., Ribeiro K.S., Vieira D.A., Abreu I.C., Silva S., Cartágenes M., Freire S.M., Borges A.C., Borges M.O. The antihypertensive effect of Syzygium cumini in spontaneously hypertensive rats. Evid Based Complement Alternat Med. 2014; 605452. https://doi.org/ 10.1155/2014/605452.
  23. Wu J., Xiao’ai F., Yan Y., Yanfen D., Yanling L., Qingchun X., Junfeng B., Yanzhong C., Zhufen L. Profiling of phenolics from Canarium pimela leaves and its vasorelaxant and antioxidant activities. Rev Bras Farmacogn. 2017; 27(6), 716–723.
  24. Magos-Guerrero G.A., Santiago-Mejía J., Carrasco O.F. Exploratory studies of some Mexican medicinal plants: cardiovascular effects in rats with and without hypertension. J Intercult Ethnopharmacol. 2017; 6(3), 274–279.
  25. Phang S.C.W., Palanisamy U.D., Kadir K.A. Effects of geraniin (rambutan rind extract) on blood pressure and metabolic parameters in rats fed a high-fat diet. J Integr Med. 2019; 17(2), 100–106.
  26. Rivlin R.S. Historical perspective on the use of garlic. J Nutr. 2001; 131(3), 951S–954S
  27. Bustanji Y., Mohammad M., Hudaib M., Tawaha K., Al-Masri I.M., Alkhatib H.S., Issa A., Alali F.Q. Screening of some medicinal plants for their pancreatic lipase inhibitory potential. Jordan J Pharm Science. 2011; 4, 81–88.
  28. Utami S., Endrini S., Nafik S., Lestari I.M.T., Anindya D., Abu Bakar E., Rozy F., Said F.F., Afifah E., Arumwardana S., Nufus H., Rihibiha D.D., Kusuma H.S.W., Wibowo S.T.H.B., Widowati W. In vitro antioxidant and antiobesity activities of freeze-dried Canarium sp., Averrhoa bilimbi L., and Malus domestica. InaBJ. 2019; 11(3), 225–337.
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