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Investigating the Effect of Taraxacum Officinalis Extract on Wistar Rats’ Infertility Induced by Cadmium Chloride | ||
| Journal of Medicinal plants and By-Products | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 02 فروردین 1403 اصل مقاله (1.07 M) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22034/jmpb.2024.364797.1653 | ||
| نویسندگان | ||
| Soraya Moradi1؛ Sajed Khaledi2؛ Mehdi Mehdinezhad Roshan3؛ Mohammadamin Eslampour4؛ Hanie Khodadadi1؛ Pejman Mortazavi* 5 | ||
| 1Graduated of Veterinary Medicine, Faculty of veterinary medicine, Science and research branch, Islamic azad university, Tehran, Iran | ||
| 2Department of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran | ||
| 3Department of Biology and Anatomical Sciences, School of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran | ||
| 4Department of clinical sciences, Faculty of veterinary medicine, Science and research branch, Islamic azad university, Tehran, Iran | ||
| 5Department of pathology, Faculty of veterinary medicine, Science and research branch, Islamic Azad University, Tehran, Iran | ||
| چکیده | ||
| Background: This study was conducted to investigate the efficacy of Taraxacum Officinalis extract on the infertility of male rats. Material and methods: In this research, we investigated the impacts of Taraxacum Officinalis extract on the infertile cadmium chloride-induced Wistar rats. Taraxacum Officinalis extract was fed to mice daily for 28 days with the help of a gavage needle. Then, all 40 rats were anesthetized with ether and dissected, then epididymis were examined morphologically. Also, we analyzed their right testes for cell line counts and H/E staining and their left testicles were analyzed to evaluate superoxide dismutase (SOD) and malondialdehyde (MDA) enzymes. Results: Our analysis of three sperm quality parameters showed a significant increase in viability, motility and the number of sperm cells in infertile groups treated with 100, 200, and 400 mg/kg Taraxacum Officinalis extract. Our SOD analysis revealed Taraxacum Officinalis extract caused to produce more enzymes in the healthy experimental groups, even compared to the healthy control group. Also, our analysis indicated that increasing the dosage of the Taraxacum Officinalis extract resulted in increasing enzyme production in infertile groups. MDA analyses showed that the healthy experimental groups produced a lower amount of MDA enzyme, which is almost the same level as the healthy control group. Also, Due to the usage of Taraxacum Officinalis extract, the level of lipid peroxidation and MDA significantly decreased. Conclusion: In the current study, Taraxacum Officinalis extract can have significant positive impacts on the viability, motility, number of sperms in oxidative stress conditions. | ||
| کلیدواژه‌ها | ||
| Taraxacum Officinalis؛ Male fertility؛ Oxidative stress؛ Spermatogenesis | ||
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آمار تعداد مشاهده مقاله: 92 تعداد دریافت فایل اصل مقاله: 77 |
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