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Ameli, Nima, Babazadeh, Daryoush, Seifdavati, Babak, Gevarigz Sangar, Shimen, Babayi, Mohammad Moeen, Soltani, Danial, Omranzadeh, Alireza. (1403). Utilizing Aspergillus Fungi, a Significant Veterinary Pathogen, in Lung Cancer Treatment: A Novel Approach. سامانه مدیریت نشریات علمی, 80(1), 1-10. doi: 10.32592/ARI.2025.80.1.1
Nima Ameli; Daryoush Babazadeh; Babak Seifdavati; Shimen Gevarigz Sangar; Mohammad Moeen Babayi; Danial Soltani; Alireza Omranzadeh. "Utilizing Aspergillus Fungi, a Significant Veterinary Pathogen, in Lung Cancer Treatment: A Novel Approach". سامانه مدیریت نشریات علمی, 80, 1, 1403, 1-10. doi: 10.32592/ARI.2025.80.1.1
Ameli, Nima, Babazadeh, Daryoush, Seifdavati, Babak, Gevarigz Sangar, Shimen, Babayi, Mohammad Moeen, Soltani, Danial, Omranzadeh, Alireza. (1403). 'Utilizing Aspergillus Fungi, a Significant Veterinary Pathogen, in Lung Cancer Treatment: A Novel Approach', سامانه مدیریت نشریات علمی, 80(1), pp. 1-10. doi: 10.32592/ARI.2025.80.1.1
Ameli, Nima, Babazadeh, Daryoush, Seifdavati, Babak, Gevarigz Sangar, Shimen, Babayi, Mohammad Moeen, Soltani, Danial, Omranzadeh, Alireza. Utilizing Aspergillus Fungi, a Significant Veterinary Pathogen, in Lung Cancer Treatment: A Novel Approach. سامانه مدیریت نشریات علمی, 1403; 80(1): 1-10. doi: 10.32592/ARI.2025.80.1.1

Utilizing Aspergillus Fungi, a Significant Veterinary Pathogen, in Lung Cancer Treatment: A Novel Approach

Archives of Razi Institute
مقاله 3، دوره 80، شماره 1، فروردین و اردیبهشت 2025، صفحه 1-10    اصل مقاله (374.26 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.32592/ARI.2025.80.1.1
نویسندگان
Nima Ameli1؛ Daryoush Babazadeh* 2؛ Babak Seifdavati3؛ Shimen Gevarigz Sangar4؛ Mohammad Moeen Babayi5؛ Danial Soltani5؛ Alireza Omranzadeh5
1Faculty of Health and Social Care, Swansea University, Wales, United Kingdom
2Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran
3Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
4Pharmacy student, School of Pharmacy, Università di Roma Tor Vergata, Rome, Italia
5Medical doctor, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Cancer stands as an enduring global health challenge, demanding innovative therapeutic approaches for effective intervention. Recent years have witnessed intensive investigations into the potential anti-cancer properties of various filamentous Aspergillus molds. This review endeavors to comprehensively examine the scientific evidence on the potential anti-tumor effects of distinct Aspergillus species and their secondary metabolites in the context of lung cancer. Numerous Aspergillus species, with Aspergillus fumigatus at the forefront, have demonstrated the capability to produce compounds holding substantial promise in anti-cancer therapeutics. Gliotoxin, one such compound, emerges as a notable agent inducing apoptosis in lung cancer cells while impeding tumor growth. Furthermore, Emericellamide A, derived from Aspergillus nidulans, exhibits significant cytotoxicity against lung cancer cells. Serotonin, sourced from Aspergillus terreus, has also been proven to exert cytotoxic effects on lung cancer cells. Cycloopiazonic acid, identified in Aspergillus flavus, has demonstrated cytotoxicity against lung cancer cells, adding to the diverse arsenal of potential anti-cancer agents. The inhibitory effects on cancer cells extend beyond mere cytotoxicity, involving processes such as apoptosis, regulation of angiogenesis, immune modulation, and suppression of proliferation. Despite the promising array of anti-cancer compounds presented by Aspergillus fungi, significant challenges persist in their identification, scalable production, and understanding of their interactions with existing therapeutic modalities. Addressing these challenges necessitates collaborative efforts, fostering synergy among researchers, clinicians, and industry stakeholders. Research into the pharmacological repertoire offered by Aspergillus fungi can only be successful with the concerted efforts of researchers in order to determine the best possible treatment options for lung cancer, leveraging the wide variety of therapeutic options available.
کلیدواژه‌ها
Aspergillus fungi؛ Cancer؛ Lung Cancer؛ Secondary metabolites؛ Veterinary pathogens
عنوان مقاله [English]
استفاده از قارچ‌های آسپرژیلوس، یک پاتوژن مهم در حوزه دامپزشکی، در درمان سرطان ریه: یک رویکرد نوین
چکیده [English]
سرطان به عنوان یک چالش مهم در حوزه سلامت جهانی باقی مانده است که نیاز به راهکارهای درمانی نوآورانه برای مداخله مؤثر دارد. در سال‌های اخیر، تحقیقات گسترده‌ای در زمینه خصوصیات ضد سرطانی احتمالی قارچ آسپرژیلوس انجام شده است. این مطالعه مروری سعی در انجام ارزیابی جامع از شواهد علمی مربوط به اثرات ضد تومور پتانسیلی انواع مختلف آسپرژیلوس و متابولیت‌های ثانویه آنها در برابر سرطان ریه دارد. تعداد زیادی از گونه‌های آسپرژیلوس، با Aspergillus fumigatus در رأس، توانایی تولید ترکیباتی را که در زمینه درمان ضد سرطان قابل توجهی دارند، اثبات کرده‌اند. گلایوتوکسین، یکی از این ترکیبات، به عنوان یک عامل قابل توجه در ایجاد آپوپتوز در سلول‌های سرطان ریه و مهار رشد تومور ظاهر می‌شود. علاوه بر این، امریسلامید A، مشتق از Aspergillus nidulans، سمیت سلولی قابل توجهی را در برابر سلول‌های سرطان ریه نشان می‌دهد. همچنین، سروتونین، مشتق از Aspergillus terreus، اثرات سمیت سلولی را در برابر سلول‌های سرطان ریه نشان داده است. ترکیب اسید سایکلوپیازونیک، شناخته شده در Aspergillus flavus، نیز سمیت سلولی را در برابر سلول‌های سرطان ریه نشان داده است. تأثیرات مهاری بر روی سلول‌های سرطان به تنهایی به سمت سمیت سلولی گسترش نمی‌یابد و شامل فرآیندهایی نظیر آپوپتوز، تنظیم آنژیوژنز، تنظیم ایمنی، و مهار افزایش تقسیم میتواند باشد. حل چالش‌های درمان سرطان نیاز به تلاش‌های مشترک دارد که همکاری بین پژوهشگران، پزشکان و مخصوصا دامپزشکان را ترویج می‌دهد. دامپزشکان می‌توانند راهی را برای درمان‌های بهتر و مؤثر و قابل استفاده برای سرطان ریه، با بهره‌گیری از تنوع غنی ترکیبات فارماکولوژیکی قارچ‌های آسپرژیلوس، به‌وجود بیاورند.
کلیدواژه‌ها [English]
قارچ‌های آسپرژیلوس, سرطان, سرطان ریه, متابولیت‌های ثانویه, پاتوژن‌های دامپزشکی
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آمار
تعداد مشاهده مقاله: 257
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