| تعداد نشریات | 283 |
| تعداد نشریات سازمان | 81 |
| تعداد شماره‌ها | 2,766 |
| تعداد مقالات | 31,497 |
| تعداد مشاهده مقاله | 39,693,837 |
| تعداد دریافت فایل اصل مقاله | 17,250,405 |
Exploring the Therapeutic Potential of Malaysian Stevia rebaudiana Bertoni leaves essential oil: A Comprehensive Study on Cell Viability and Biological Effects for Topical Applications | ||
| Journal of Medicinal plants and By-Products | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 16 خرداد 1403 اصل مقاله (1.21 M) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22034/jmpb.2024.361730.1541 | ||
| نویسندگان | ||
| Nur Izzati Mohamad Zen1؛ Uswatun Hasanah Zaidan* 1، 2؛ Siti Salwa Abd. Gani1، 3؛ Suhaili Shamsi2؛ Masriana Hassan4؛ Nazrim Marikkar5 | ||
| 1Halal Products Research Institute, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia | ||
| 2Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia | ||
| 3Department of Agriculture Technology, Faculty of Agriculture, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia | ||
| 4Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia | ||
| 5National Institute of Fundamental Studies Hanthana Road, 20000 Kandy, Sri Lanka | ||
| چکیده | ||
| Background: The abundance of plant resources in Malaysia has gained the attention of many researchers to explore more pharmacological effects of plant’s essential oil (EO). EO from Stevia rebaudiana Bertoni (SrB-EO) leaves consists of a rich blend of a variety of volatile molecules and bioactive compounds which currently attract the attention of a lot of researchers due to its high potential to play a role in the therapeutic activity. Methods: In the present study, SrB-EO used was extracted using a Soxhlet extractor in absolute ethanol. The cell viability on SrB-EO has been investigated using Hs27 skin fibroblast cells against two biological assessments; anti-inflammatory and antimicrobial assays. Results: It shows that 500 µg/mL was the highest concentration of SrB-EO which is considered non-toxic (82.08% cell viability) and demonstrates a primary significant cell proliferative effect toward cells. The maximum inhibition percentage of nitrite of SrB-EO was 33.12%, which showed a good anti-inflammatory property and SrB-EO showed an antimicrobial effect toward Gram-positive bacteria; Bacillus subtilis B29 and Staphylococcus aureus ATCC 43300. The minimal inhibition concentration (MIC) of B. subtilis and S. aureus were 6.25 mg/mL and 3.13 mg/mL of SrB-EO respectively, and the minimal bactericidal concentration (MBC) of B. subtilis and S. aureus were 12.50 mg/mL and 10.42 mg/mL of SrB-EO, respectively. Conclusion: This study concluded that a low concentration of SrB-EO is non-toxic toward human skin cells and these EOs possess satisfactory anti-inflammatory and antibacterial properties. Thus, SrB-EO can be used as an alternative therapeutic agent for topical application in the medicinal field. | ||
| کلیدواژه‌ها | ||
| Essential oil؛ Stevia rebaudiana Bertoni؛ Cytotoxicity؛ Anti-inflammatory؛ Antimicrobial activity | ||
|
آمار تعداد مشاهده مقاله: 39 تعداد دریافت فایل اصل مقاله: 34 |
||