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Malekzadeh, Davoud, Abdolmaleki, Arash, Dehghan, Gholamreza, Asadi, Asadollah, ghabaei, Amirreza, A. Ghanimi, Hussein. (1404). Enhanced Cognitive and Behavioral Function as well as Neurobiochemical Enzyme Activities in Aluminum-Exposed Rats through Cerium Oxide Nanoparticles (CeO2 NPs). سامانه مدیریت نشریات علمی, 80(2), 437-449. doi: 10.32592/ARI.2025.80.2.437
Davoud Malekzadeh; Arash Abdolmaleki; Gholamreza Dehghan; Asadollah Asadi; Amirreza ghabaei; Hussein A. Ghanimi. "Enhanced Cognitive and Behavioral Function as well as Neurobiochemical Enzyme Activities in Aluminum-Exposed Rats through Cerium Oxide Nanoparticles (CeO2 NPs)". سامانه مدیریت نشریات علمی, 80, 2, 1404, 437-449. doi: 10.32592/ARI.2025.80.2.437
Malekzadeh, Davoud, Abdolmaleki, Arash, Dehghan, Gholamreza, Asadi, Asadollah, ghabaei, Amirreza, A. Ghanimi, Hussein. (1404). 'Enhanced Cognitive and Behavioral Function as well as Neurobiochemical Enzyme Activities in Aluminum-Exposed Rats through Cerium Oxide Nanoparticles (CeO2 NPs)', سامانه مدیریت نشریات علمی, 80(2), pp. 437-449. doi: 10.32592/ARI.2025.80.2.437
Malekzadeh, Davoud, Abdolmaleki, Arash, Dehghan, Gholamreza, Asadi, Asadollah, ghabaei, Amirreza, A. Ghanimi, Hussein. Enhanced Cognitive and Behavioral Function as well as Neurobiochemical Enzyme Activities in Aluminum-Exposed Rats through Cerium Oxide Nanoparticles (CeO2 NPs). سامانه مدیریت نشریات علمی, 1404; 80(2): 437-449. doi: 10.32592/ARI.2025.80.2.437

Enhanced Cognitive and Behavioral Function as well as Neurobiochemical Enzyme Activities in Aluminum-Exposed Rats through Cerium Oxide Nanoparticles (CeO2 NPs)

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مقاله 19، دوره 80، شماره 2، خرداد و تیر 2025، صفحه 437-449    اصل مقاله (1.01 M)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2025.80.2.437
نویسندگان
Davoud Malekzadeh1؛ Arash Abdolmaleki* 2؛ Gholamreza Dehghan1؛ Asadollah Asadi2؛ Amirreza ghabaei3؛ Hussein A. Ghanimi4
1Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.
2Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
3Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran.
4College of Nursing, University of Al-Ameed, Karbala, Iraq
چکیده
Neurological and behavioral diseases caused by toxic metals, particularly aluminum, continue to pose a substantial issue for humans. Given that aluminum is the most prevalent metal found in the earth's crust, it is inevitable to come into touch with aluminum for humans in all over the world. This work focuses on the synthesis and assessment of the therapeutic impact of cerium oxide nanoparticles (CeO2 NPs) in rats that have been exposed to aluminum. We assessed the effect of CeO2 nanoparticles on the functionality of enzymes and markers related to oxidative stress, including catalase (CAT), cholinesterase (ChE), malondialdehyde (MDA), total antioxidant capacity (TAC), monoamine oxidase (MAO), reduced glutathione (GSH), and superoxide dismutase (SOD) in the cerebral and hepatic tissues of rats subjected to aluminum exposure. Aluminum chloride was administered to the rats through subcutaneous injection at a daily dosage of 150 mg/kg for a duration of 3 weeks in order to generate oxidative stress. CeO2 nanoparticles (NPs) were administered intraperitoneally at dosages of 5 and 10 mg/kg for one week, starting from the third week. The findings demonstrated that CeO2 nanoparticles (NPs) were very successful in enhancing cognitive-behavioral patterns and increasing the activity of neurobiochemical enzymes in both liver and brain tissues. The findings indicated that CeO2 NPs might serve as a good therapeutic approach for addressing neuro-cognitive and neurobiochemical impairments caused by high levels of aluminum pollution in aluminum exposed rats model. However, it is indisputable that more investigation is necessary to evaluate the therapeutic effectiveness of CeO2 NPs on conditions caused by hazardous metal exposure.
کلیدواژه‌ها
CeO2 NPs؛ Aluminum toxicity؛ Oxidative stress؛ Neurobiochemical enzymes
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مراجع
  1. Fernandes RM, Eiró LG, dos Santos Chemelo V, Alvarenga MOP, Lima RR. Aluminum toxicity and oxidative stress. Toxicology: Elsevier; 2021. p. 35-127.
  2. Rahimzadeh MR, Rahimzadeh MR, Kazemi S, Amiri RJ, Pirzadeh M, Moghadamnia AA. Aluminum poisoning with emphasis on its mechanism and treatment of intoxication. Emergency medicine international. 2022.
  3. Mold MJ, O’Farrell A, Morris B, Exley C. Aluminum and tau in neurofibrillary tangles in familial Alzheimer’s disease. Journal of Alzheimer's Disease 2021;5(1):94-283.
  4. Das N, Raymick J, Sarkar S. Role of metals in Alzheimer’s disease. Metabolic brain disease. 2021;36(7):39-1627.
  5. Liu Y, Nguyen M, Robert A, Meunier B. Metal ions in Alzheimer’s disease: a key role or not0 Accounts of chemical research. 2019;52(7); 2026-35.
  6. Cheng H, Yang B, Ke T, Li S, Yang X, Aschner M, et al. Mechanisms of metal-induced mitochondrial dysfunction in neurological disorders. Toxics. 2021;9(6):142.
  7. Kumar V, Gill KD. Oxidative stress and mitochondrial dysfunction in aluminium neurotoxicity and its amelioration: a review. Neurotoxicology. 2014;(41):154-66.
  8. Sadauskiene I, Liekis A, Staneviciene I, Naginiene R, Ivanov L. Effects of long-term supplementation with aluminum or selenium on the activities of antioxidant enzymes in mouse brain and liver. Catalysts. 2020;10(5):585.
  9. Campbell A, Prasad KN, Bondy SC. Aluminum-induced oxidative events in cell lines: glioma are more responsive than neuroblastoma. Free Radical Biology and Medicine. 1999;26(9-10):1166-71.
  10. Chelikani P, Fita I, Loewen PC. Diversity of structures and properties among catalases. Cellular and Molecular Life Sciences CMLS. 2004;61:192-208.
  11. Couto N, Wood J, Barber J. The role of glutathione reductase and related enzymes on cellular redox homoeostasis network. Free radical biology and medicine. 2016;95:27-42.
  12. Nelson BC, Johnson ME, Walker ML, Riley KR, Sims CM. Antioxidant cerium oxide nanoparticles in biology and medicine. Antioxidants. 2016;5(2):
  13. Chelliah M, Rayappan JBB, Krishnan UM. Synthesis and characterization of cerium oxide nanoparticles by hydroxide mediated approach. Journal of Applied Sciences. 2012;12(16):1734-7.
  14. Nandi A, Yan L-J, Jana CK, Das N. Role of catalase in oxidative stress-and age-associated degenerative diseases. Oxidative medicine and cellular longevity. 2019;
  15. Sies H. Role of metabolic H2O2 generation: redox signaling and oxidative stress. Journal of Biological Chemistry. 2014;289(13):8735-41.
  16. Ghosal A. Evaluation of the clearance mechanism of non-CYP-mediated drug metabolism and DDI as a victim drug. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters: Elsevier; 2020. p. 237-71.
  17. Askar KA, Kudi AC, Moody AJ. Comparative analysis of cholinesterase activities in food animals using modified Ellman and Michel assays. Canadian Journal of Veterinary Research. 2011;75(4):261-70.
  18. Ma Y, Gao W, Ma S, Liu Y, Lin W. Observation of the elevation of cholinesterase activity in brain glioma by a near-infrared emission chemsensor. Analytical Chemistry. 2020;92(19):13405-10.
  19. Ellman GL, Courtney KD, Andres Jr V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical pharmacology. 1961;7(2):88-95.
  20. Lassiter T, Barone Jr S, Padilla S. Ontogenetic differences in the regional and cellular acetylcholinesterase and butyrylcholinesterase activity in the rat brain. Developmental brain research. 1998;105(1):109-23.
  21. Papandreou MA, Tsachaki M, Efthimiopoulos S, Cordopatis P, Lamari FN, Margarity M. Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection. Behavioural brain research. 2011;219(2):197-204.
  22. Linardaki ZI, Orkoula MG, Kokkosis AG, Lamari FN, Margarity M. Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment. Food and Chemical Toxicology. 2013;52:163-70.
  23. Wang X, Zhang D, Song W, Cai CF, Zhou Z, Fu Q, et al. Neuroprotective effects of the aerial parts of Polygala tenuifolia Willd extract on scopolamine‑induced learning and memory impairments in mice. Biomedical Reports. 2020;13(5):1-.
  24. Gaweł S, Wardas M, Niedworok E, Wardas P. Malondialdehyde (MDA) as a lipid peroxidation marker. Wiadomosci lekarskie (Warsaw, Poland: 1960). 2004;57(9-10):453-5.
  25. Aoyama K, Nakaki T. Impaired glutathione synthesis in neurodegeneration. International journal of molecular sciences. 2013;14(10):21021-44.
  26. Johnson WM, Wilson-Delfosse AL, Mieyal JJ. Dysregulation of glutathione homeostasis in neurodegenerative diseases. Nutrients. 2012;4(10):1399-440.
  27. Wang Y, Branicky R, Noë A, Hekimi S. Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling. Journal of Cell Biology. 2018;217(6):1915-28.
  28. Assady M, Farahnak A, Golestani A, Esharghian M. Superoxide dismutase (SOD) enzyme activity assay in Fasciola spp. parasites and liver tissue extract. Iranian journal of parasitology. 2011;6(4):
  29. Bihaqi SW, Sharma M, Singh AP, Tiwari M. Neuroprotective role of Convolvulus pluricaulis on aluminium induced neurotoxicity in rat brain. Journal of ethnopharmacology. 2009;124(3):409-15.
  30. Benyettou I, Kharoubi O, Hallal N, Benyettou HA, Tair K, Belmokhtar M, et al. Aluminium-induced behavioral changes and oxidative stress in developing rat brain and the possible ameliorating role of Omega-6/Omega-3 J Biol Sci. 2017;17(3):106-17.
  31. Ranjbar A, Soleimani Asl S, Firozian F, Heidary Dartoti H, Seyedabadi S, Taheri Azandariani M, et al. Role of cerium oxide nanoparticles in a paraquat-induced model of oxidative stress: emergence of neuroprotective results in the brain. Journal of Molecular Neuroscience. 2018;66:420-7.
  32. Zavvari F, Nahavandi A, Shahbazi A. Neuroprotective effects of cerium oxide nanoparticles on experimental stress-induced depression in male rats. Journal of Chemical Neuroanatomy. 2020;106:101799.
  33. Soluki M, Mahmoudi F, Abdolmaleki A, Asadi A, Sabahi Namini Cerium oxide nanoparticles as a new neuroprotective agent to promote functional recovery in a rat model of sciatic nerve crush injury. British Journal of Neurosurgery. 2020:1-6.
  34. Dutta D, Mukherjee R, Ghosh S, Patra M, Mukherjee M, Basu T. Cerium oxide nanoparticles as antioxidant or pro-oxidant agents. ACS Applied Nano Materials. 2022;5(1):1690-701.
  35. Estevez AY, Ganesana M, Trentini JF, Olson JE, Li G, Boateng YO, et al. Antioxidant enzyme-mimetic activity and neuroprotective effects of cerium oxide nanoparticles stabilized with various ratios of citric acid and EDTA. Biomolecules. 2019;9(10):
  36. Elshony N, Nassar AM, El-Sayed YS, Samak D, Noreldin A, Wasef L, et al. Ameliorative role of cerium oxide nanoparticles against fipronil impact on brain function, oxidative stress, and apoptotic cascades in albino rats. Frontiers in Neuroscience. 2021;15:651471.
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