اخبار و اعلانات

 آمار

تعداد نشریات285
تعداد نشریات سازمان83
تعداد شماره‌ها3,107
تعداد مقالات34,629
تعداد مشاهده مقاله49,705,715
تعداد دریافت فایل اصل مقاله80,111,489
Yousefi, Alireza, Mardkhoshnood, Mehdi, Zarenezhad, Ali, Zarenezhad, Elham, Barbaresi, Silvia, Ghasemian, Abdolmajid. (1404). Chelidonium majus and Valeriana officinalis hydro-alcoholic extracts exert healing efects on wounds in vivo. سامانه مدیریت نشریات علمی, 80(4), 987-993. doi: 10.32592/ARI.2025.80.4.987
Alireza Yousefi; Mehdi Mardkhoshnood; Ali Zarenezhad; Elham Zarenezhad; Silvia Barbaresi; Abdolmajid Ghasemian. "Chelidonium majus and Valeriana officinalis hydro-alcoholic extracts exert healing efects on wounds in vivo". سامانه مدیریت نشریات علمی, 80, 4, 1404, 987-993. doi: 10.32592/ARI.2025.80.4.987
Yousefi, Alireza, Mardkhoshnood, Mehdi, Zarenezhad, Ali, Zarenezhad, Elham, Barbaresi, Silvia, Ghasemian, Abdolmajid. (1404). 'Chelidonium majus and Valeriana officinalis hydro-alcoholic extracts exert healing efects on wounds in vivo', سامانه مدیریت نشریات علمی, 80(4), pp. 987-993. doi: 10.32592/ARI.2025.80.4.987
Yousefi, Alireza, Mardkhoshnood, Mehdi, Zarenezhad, Ali, Zarenezhad, Elham, Barbaresi, Silvia, Ghasemian, Abdolmajid. Chelidonium majus and Valeriana officinalis hydro-alcoholic extracts exert healing efects on wounds in vivo. سامانه مدیریت نشریات علمی, 1404; 80(4): 987-993. doi: 10.32592/ARI.2025.80.4.987

Chelidonium majus and Valeriana officinalis hydro-alcoholic extracts exert healing efects on wounds in vivo

Archives of Razi Institute
مقاله 20، دوره 80، شماره 4، مهر و آبان 2025، صفحه 987-993    اصل مقاله (420.84 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2025.80.4.987
نویسندگان
Alireza Yousefi1؛ Mehdi Mardkhoshnood2؛ Ali Zarenezhad2؛ Elham Zarenezhad2؛ Silvia Barbaresi3؛ Abdolmajid Ghasemian* 2
1Razi Vaccine and Serum Research Institute, Agricultural Research, Education, and Extension Organization (AREEO), Karaj, Iran
2Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
3Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium.
چکیده
The study objective was assessment of wound healing traits of Valeriana officinalis and Chelidonium majus hydro-alcoholic (HA) extracts on surgical wounds in Wistar rats. The HA root extracts were separated using percolator and 96 degree alcohol in desiccator device. In addition, 24 Wistar rats (six months and 200 gr) were divided into three groups including control, V. officinalis and C. majus. The wound creation (2 cm diameter) was developed by initial intraperitoneal injection of anesthetic drugs (5% ketamine and 5mg/kg of diazepam) and hair shaving. After 24 hrs of wound creation, the treatment using ointment containing 5% of each V. officinalis and C. majus HA extract was implemented for 21 days. The wound imaging on days 4, 7, 14 and 21 was performed using a digital camera. Additionally, histopathologic examination of wounds was conducted at 4, 7, 14 and 21-day intervals. The microscopic and macroscopic observations revealed significant higher wound healing rates in treated groups compared to the control. The histopathologic examinations inferred the sufficient angiogenesis, existence of collagen and fibroblast cells and decrease in the inflammatory cells. Moreover, wound contraction was observed in treated groups. Noticeably, the C. majus HA extract treated the wounds more efficiently. The wound healing of Wistar rats using HA extracts from V. officinalis and C. majus was promising though more investigations are required. Additionally, C. majus HA extract had higher healing effect compared to that of V. officinalis. It is proposed to evaluate the cytotoxic levels of extracts and formulate them in future studies to achieve more efficient and rapid healing of wounds. In addition, combination of extracts from various herbal medicines and with synthetic drugs can be studied for wound healing.
کلیدواژه‌ها
Wound healing؛ Valeriana officinalis؛ Chelidonium majus؛ hydro-alcoholic extracts؛ in vivo
سایر فایل های مرتبط با مقاله
مراجع
  1. Fernández-Gallego N, Sánchez-Madrid F, Cibrian D. Role of AHR Ligands in Skin Homeostasis and Cutaneous Inflammation. Cells. 2021;10(11).https://doi.org/10.3390/cells10113176.
  2. Ashjazadeh MA, Jahandideh A, Abedi G, Akbarzadeh A, Hesaraki S. Histopathology and Histomorphological Study of Wound Healing Using Clove Extract Nanofibers (Eugenol) Compared to Zinc Oxide Nanofibers on the Skin of Rats. Arch Razi Inst. 2019;74(3):267-77.https://doi.org/10.22092/ari.2018.120170.1184.
  3. Hakimzadeh S, Kosar M. Wound healing activity of green synthesized copper nanoparticles through cell proliferation-migration, antimicrobial effects, and nitric oxide triggering. Archives of Razi Institute. 2023;10.22092/ari.2023.363883.2905:-.https://doi.org/10.22092/ari.2023.363883.2905.
  4. Rousselle P, Montmasson M, Garnier C. Extracellular matrix contribution to skin wound re-epithelialization. Matrix Biol. 2019;75-76:12-26.https://doi.org/10.1016/j.matbio.2018.01.002.
  5. Wilkinson HN, Hardman MJ. Wound healing: cellular mechanisms and pathological outcomes. Open Biol. 2020;10(9):200223.https://doi.org/10.1098/rsob.200223.
  6. LeBlanc K, Langemo D, Woo K, Campos HMH, Santos V, Holloway S. Skin tears: prevention and management. Br J Community Nurs. 2019;24(Sup9):S12-s8.https://doi.org/10.12968/bjcn.2019.24.Sup9.S12.
  7. Ratnayake P, Udalamaththa V, Samaratunga U, Seneviratne J, Udagama P. Therapeutic Potential of Skin Stem Cells and Cells of Skin Origin: Effects of Botanical Drugs Derived from Traditional Medicine. Stem Cell Rev Rep. 2022;18(6):1986-2001.https://doi.org/10.1007/s12015-022-10388-y.
  8. Krizhanovska V, Sile I, Kronberga A, Nakurte I, Mezaka I, Dambrova M, et al. The Cultivation of Chelidonium majus L. Increased the Total Alkaloid Content and Cytotoxic Activity Compared with Those of Wild-Grown Plants. Plants (Basel). 2021;10(9).https://doi.org/10.3390/plants10091971.
  9. Popovic A, Deljanin M, Popovic S, Todorovic D, Djurdjevic P, Matic S, et al. Chelidonium majus crude extract induces activation of peripheral blood mononuclear cells and enhances their cytotoxic effect toward HeLa cells. Int J Environ Health Res. 2022;32(7):1554-66.https://doi.org/10.1080/09603123.2021.1897534.
  10. Gardin NE, Braga AJ. Preliminary outcome of Chelidonium majus (greater celandine) for COVID-19. Phytother Res. 2023;10.1002/ptr.7776.https://doi.org/10.1002/ptr.7776.
  11. Sathasivam R, Yeo HJ, Park CH, Choi M, Kwon H, Sim JE, et al. Molecular Characterization, Expression Analysis of Carotenoid, Xanthophyll, Apocarotenoid Pathway Genes, and Carotenoid and Xanthophyll Accumulation in Chelidonium majus L. Plants (Basel). 2021;10(8).https://doi.org/10.3390/plants10081753.
  12. Huang XY, Shao ZX, An LJ, Xue JJ, Li DH, Li ZL, et al. New lignanamides and alkaloids from Chelidonium majus and their anti-inflammation activity. Fitoterapia. 2019;139:104359.https://doi.org/10.1016/j.fitote.2019.104359.
  13. Nawrot R, Warowicka A, Rudzki PJ, Musidlak O, Dolata KM, Musijowski J, et al. Combined Protein and Alkaloid Research of Chelidonium majus Latex Reveals CmMLP1 Accompanied by Alkaloids with Cytotoxic Potential to Human Cervical Carcinoma Cells. Int J Mol Sci. 2021;22(21).https://doi.org/10.3390/ijms222111838.
  14. Liu Y, Peng Y, Zhang Z, Guo X, Ji M, Zheng J. In vitro and in vivo studies of the metabolic activation of chelidonine. Chem Biol Interact. 2019;308:155-63.https://doi.org/10.1016/j.cbi.2019.05.012.
  15. Pinheiro ML, Alcântara CE, de Moraes M, de Andrade ED. Valeriana officinalis L. for conscious sedation of patients submitted to impacted lower third molar surgery: A randomized, double-blind, placebo-controlled split-mouth study. J Pharm Bioallied Sci. 2014;6(2):109-14.https://doi.org/10.4103/0975-7406.129176.
  16. Farah GJ, Ferreira GZ, Danieletto-Zanna CF, Luppi CR, Jacomacci WP. Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study. J Oral Maxillofac Surg. 2019;77(9):1796.e1-.e8.https://doi.org/10.1016/j.joms.2019.05.003.
  17. Feng Y, Dai W, Ke J, Cui Y, Li S, Ma J, et al. Protective effect of valerian extract capsule (VEC) on ethanol- and indomethacin-induced gastric mucosa injury and ameliorative effect of VEC on gastrointestinal motility disorder. Pharm Biol. 2022;60(1):1095-105.https://doi.org/10.1080/13880209.2022.2071449.
  18. Bhargava S, Malhotra H, Rathore OS, Malhotra B, Sharma P, Batra A, et al. Anti-leukemic activities of alcoholic extracts of two traditional Indian medicinal plants. Leuk Lymphoma. 2015;56(11):3168-82.https://doi.org/10.3109/10428194.2015.1026813.
  19. Sato H, Ebisawa K, Takanari K, Yagi S, Toriyama K, Yamawaki-Ogata A, et al. Skin-derived precursor cells promote wound healing in diabetic mice. Ann Plast Surg. 2015;74(1):114-20.https://doi.org/10.1097/sap.0000000000000342.
  20. Navarro-Triviño FJ, Arias-Santiago S, Gilaberte-Calzada Y. Vitamin D and the Skin: A Review for Dermatologists. Actas Dermosifiliogr (Engl Ed). 2019;110(4):262-72.https://doi.org/10.1016/j.ad.2018.08.006.
  21. Baker LB. Physiology of sweat gland function: The roles of sweating and sweat composition in human health. Temperature (Austin). 2019;6(3):211-59.https://doi.org/10.1080/23328940.2019.1632145.
  22. Maver T, Maver U, Stana Kleinschek K, Smrke DM, Kreft S. A review of herbal medicines in wound healing. International journal of dermatology. 2015;54(7):740-51
  23. Teplicki E, Ma Q, Castillo DE, Zarei M, Hustad AP, Chen J, et al. The Effects of Aloe vera on Wound Healing in Cell Proliferation, Migration, and Viability. Wounds. 2018;30(9):263-8
  24. Coelho FH, Salvadori G, Rados PV, Magnusson A, Danilevicz CK, Meurer L, et al. Topical Aloe Vera (Aloe barbadensis Miller) Extract Does Not Accelerate the Oral Wound Healing in Rats. Phytother Res. 2015;29(7):1102-5.https://doi.org/10.1002/ptr.5352.
  25. Samuelson R, Lobl M, Higgins S, Clarey D, Wysong A. The Effects of Lavender Essential Oil on Wound Healing: A Review of the Current Evidence. J Altern Complement Med. 2020;26(8):680-90.https://doi.org/10.1089/acm.2019.0286.
  26. Ben Djemaa FG, Bellassoued K, Zouari S, El Feki A, Ammar E. Antioxidant and wound healing activity of Lavandula aspic L. ointment. J Tissue Viability. 2016;25(4):193-200.https://doi.org/10.1016/j.jtv.2016.10.002.
  27. Niknam S, Tofighi Z, Faramarzi MA, Abdollahifar MA, Sajadi E, Dinarvand R, et al. Polyherbal combination for wound healing: Matricaria chamomilla L. and Punica granatum L. Daru. 2021;29(1):133-45.https://doi.org/10.1007/s40199-021-00392-x.
  28. Nezhad-Mokhtari P, Kazeminava F, Abdollahi B, Gholizadeh P, Heydari A, Elmi F, et al. Matricaria chamomilla essential oil-loaded hybrid electrospun nanofibers based on polycaprolactone/sulfonated chitosan/ZIF-8 nanoparticles for wound healing acceleration. Int J Biol Macromol. 2023;247:125718.https://doi.org/10.1016/j.ijbiomac.2023.125718.
  29. Kazemian H, Ghafourian S, Sadeghifard N, Houshmandfar R, Badakhsh B, Taji A, et al. In vivo Antibacterial and Wound Healing Activities of Roman Chamomile (Chamaemelum nobile). Infect Disord Drug Targets. 2018;18(1):41-5.https://doi.org/10.2174/1871526516666161230123133.
  30. Labib RM, Ayoub IM, Michel HE, Mehanny M, Kamil V, Hany M, et al. Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations. PLoS One. 2019;14(9):e0219561.https://doi.org/10.1371/journal.pone.0219561.
آمار
تعداد مشاهده مقاله: 372
تعداد دریافت فایل اصل مقاله: 239


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب