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Investigation of the Effect of Extremely Low-Frequency Electromagnetic Fields Exposure and Curcumin During the Embryonic Period on Catalase and Superoxide Dismutase Activities of Plasma and Liver Tissue of Juvenile Wistar Rats | ||
| Journal of Medicinal plants and By-products | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 03 فروردین 1404 اصل مقاله (1.03 M) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22034/jmpb.2025.367258.1783 | ||
| نویسندگان | ||
| Mohammad Hassan Kalantar Neyestanki1؛ Farideh Jalali Mashayekhi2؛ Fatemeh Samimi2؛ Homa Soleimani* 1، 3 | ||
| 1Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran | ||
| 2Department of Biochemistry and Genetics, School of Medicine, Arak University of Medical Sciences, Arak, I.R. Iran | ||
| 3Department of Medical physics, School of Paramedical Sciences, Arak University of Medical Sciences, Arak, Iran | ||
| چکیده | ||
| To investigate the effectiveness of extremely low-frequency electromagnetic field (ELF-EMF) and curcumin on the enzyme level of Catalase (CAT) and Superoxide Dismutase (SOD) in the plasma and liver of neonates that had been irradiated during pregnancy. Five males and twenty female rats were mated, and vaginal plaques were observed. The pregnant rats were then divided into six groups. During pregnancy, the EMF group was exposed to ELF-EMF for 30 min/day, the curcumin group received a single intraperitoneal dose of 50 mg/kg curcumin, and the EMF + Curcumin group was exposed to ELF-EMF and injected intraperitoneally with curcumin. The DMSO group was injected intraperitoneally with DMSO (curcumin solvent), and the sham group was placed in the solenoid under the same conditions as the EMF group but without ELF-EMF exposure. The sixth group was the control group. After birth, the offspring were breastfed by their mothers until the end of the lactation period (28 days). Once the offspring reached 4 weeks of age, they were sacrificed, separated by sex, and divided into six experimental groups according to their mothers' groups assignments. CAT and SOD levels in the plasma and liver were assayed. Data analysis showed curcumin and stress changed serum SOD (P = 0.021) and CAT tissue (P = 0.033) levels based on gender. Additionally, ELF-EMF exposure reduced serum catalase activity (P = 0.002). This change was sex-dependent, and in the presence of curcumin, the mean values returned to the normal level. ELF-EMF (1.5mT) exposure during pregnancy had a potentially sex-dependent effect on serum CAT activity in juveniles. | ||
| کلیدواژه‌ها | ||
| Radiation exposure؛ Diferuloylmethane, Superoxide dismutase, Catalase, Embryonic period | ||
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آمار تعداد مشاهده مقاله: 249 تعداد دریافت فایل اصل مقاله: 175 |
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