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Evaluation of Antioxidant Activity and Effect of Cyperus Rotundus L Flower Extract on Prostate Cancer Cells | ||
| Journal of Medicinal plants and By-products | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 12 فروردین 1404 اصل مقاله (1.01 M) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22034/jmpb.2025.368342.1872 | ||
| نویسندگان | ||
| Asana Ahmadi* 1؛ Reza Naghiha2؛ Abolfazl Ahmadi3 | ||
| 1Department of Chemistry, Faculty of Basic Sciences, Yasouj University, Yasouj, Iran | ||
| 2Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran | ||
| 3Department of Chemical Engineering, South Pars Twelfth Refinery, Bandar Siraf, Iran | ||
| چکیده | ||
| Cyperus Rotundus, a member of the Cyperaceae family, is classified as a monocotyledonous weed. C. rotundus tuber has been recognized as a traditional remedy for indigestion, vomiting, diarrhea, and other intestinal ailments, particularly in children. It is light, bitter, astringent, sedative, carminative, diuretic, anthelmintic, expectorant, laxative and nerve tonic. This study presents an evaluation of the antioxidant activity of Cyperus Rotundus flower extract using the DPPH method for the first time. The analysis was conducted with two solvents: ethanol and dimethyl sulfoxide (DMSO). Additionally, the study assessed the mineral content with antioxidant properties through ICP-MS and the anticancer effects of the flower extract in the context of controlling and treating prostate cancer. The comparative analysis of the antioxidant activities of ethanol, dimethyl sulfoxide (DMSO), and vitamin C has demonstrated that vitamin C possesses a superior antioxidant capacity compared to the other solvents. Additionally, the extract obtained using DMSO as a solvent exhibits a higher antioxidant activity than that derived from ethanol solvent. IC50 comparison between two groups of extract with ethanol solvent and extract with DMSO solvent showed that the antioxidant activity of the extract depends on the concentration and solvent. Also, among the minerals with antioxidant properties, magnesium, and sulfur were the highest and the lowest for copper and selenium. Investigating the anticancer activity of flower extract between 24, 48, and 72 hours has shown that the lowest cell viability after 72 hours is at the concentration of 1600 µg/ml, and the flower extract as a new preventive or therapeutic drug for the treatment of patients to be considered prostate cancer and needs more research. | ||
| کلیدواژه‌ها | ||
| Antioxidant activity؛ Ethanol؛ Dimethyl Sulfoxide؛ Minerals؛ Anticancer activity | ||
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آمار تعداد مشاهده مقاله: 85 تعداد دریافت فایل اصل مقاله: 84 |
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