| تعداد نشریات | 286 |
| تعداد نشریات سازمان | 84 |
| تعداد شماره‌ها | 3,011 |
| تعداد مقالات | 33,659 |
| تعداد مشاهده مقاله | 44,657,786 |
| تعداد دریافت فایل اصل مقاله | 35,162,041 |
Study on Prevalence of Parasitic Infections among Hepatitis C Virus Patients in Egypt | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 25 فروردین 1404 اصل مقاله (872.47 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2025.367275.3374 | ||
| نویسندگان | ||
| Maryam Samwel Garas1؛ Hoda H Taha2؛ Rafaat Abdel Rahman3؛ Marwa Aboueldahab1؛ Ahmed Hamdy Nigm* 4 | ||
| 1Department of Zoology, Faculty of science, Ain Shams University, Abbasia, Cairo, Egypt | ||
| 2Zoology department, Faculty of science, Ain Shams University, Abbasia- Ghalifa Mamoon street - cairo -Egypt | ||
| 3Department of immunology, the Blood Research Center in the Egyptian Armed Forces, Cairo, Egypt | ||
| 4Zoology department, Faculty of Science, Ain Shams University, Abbasia- Ghalifa Mamoon street - cairo -Egypt | ||
| چکیده | ||
| Hepatitis C virus (HCV) is a viral infection affecting 71 million people globally. The highest prevalence was estimated in parasitic infections, such as Schistosoma mansoni, Fasciola sp., and Toxoplasma gondii, which can also contribute to liver disease progression. This study aimed to investigate the prevalence of co-parasitic infections with HCV in Egyptian populations and the resulting biochemical changes in liver and kidney biomarkers. Three hundred and thirty-seven blood samples were screened molecularly for HCV and immunologically for parasitic infections using PCR and ELISA assays, respectively. The liver functions were monitored by measuring the serum glutamic oxaloacetic transaminase (GOT), glutamate pyruvate alanine aminotransferase (GPT), gamma-glutamyl transferase (GGT), total protein (TP), albumin (Alb), total bilirubin (T Bil), and alkaline phosphatase (ALK). The kidney functions were evaluated by estimation of the creatinine, uric acid, urea, sodium (Na), and potassium (K) levels. The patients were categorized according to gender and age < 21, 21 - 50, and > 50 years. Results indicated that 120 out of 287 HCV-infected cases (41.8%) have Schistosoma infection, of which 57, 31, 24, and 8 cases were mono-infected and co-infected with Fasciola, Toxoplasma, and Fasciola/Toxoplasma, respectively. Ninety-nine out of 287 HCV patients (34.5%) have F. hepatica infection, of which 51 and 9 cases were mono-infected and Toxoplasma co-infected, respectively. 87 out of 287 HCV samples (30.3%) have T. gondii infection, of which 46 cases were mono-infected. Besides, the percentage of males in the patient groups having monoparasitic infection was between 78.2% (Toxoplasma) and 84.3% (S. mansoni or F. hepatica), on the other hand, the highest incidences of single infections among males (Fasciola and Toxoplasma) were over the age of 50 years, at 43.1% and 39.1%, respectively. In male patients mono-infected with S. mansoni (42.1%), the prevalence was in age group of 21-50 years. It was found that liver enzyme levels (GPT, GOT, Alk, and GGT) besides, kidney parameters (creatinine and urea) were more affected by the type (mono or mixed) or species of parasitic infections in HCV patients. Additionally, most of the serological parameters were significantly elevated with viral/parasitic infections, especially, in patients with high viral loads. | ||
| کلیدواژه‌ها | ||
| Hepatitis C؛ Schistosoma؛ Fasciola؛ Toxoplasma؛ liver and kidney functions | ||
|
آمار تعداد مشاهده مقاله: 40 تعداد دریافت فایل اصل مقاله: 26 |
||