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Pathological Study on Prevalence and Morphopatholgical Patterns of Ovine Pulmonary Adenocarcinoma in Slaughtered Sheep in Semnan Province, Northeast Iran | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 25 فروردین 1404 اصل مقاله (467.7 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2025.367360.3380 | ||
| نویسندگان | ||
| Afshin Zahedi* 1؛ Keivan Jamshidi2 | ||
| 1Department of Veterinary Pathology, Faculty of Veterinary Medicine, Islamic Azad University, Rasht, Iran | ||
| 2Department of Veterinary Pathology, Islamic Azad University, Garmsar Branch, Semnan, Iran | ||
| چکیده | ||
| Ovine pulmonary adenocarcinoma a disease is a spontaneous lung tumor caused by retrovirus in sheep sharing notable similarities with certain types of human adenocarcinoma. This study was carried out in Semnan province, Northeast Iran, for a period of six months from April to September 2016. A total number of 4079 local breed sheep, divided in three age groups as <1, 1–2, and >2 years old, were subjected to post-slaughter examination in Semnan abattoir to detect any pathological lesions. Macroscopic pneumonic lesions were found and detected in the lungs of 259 (6.35%) sheep. During the gross examination, 189 lungs (73%) were collected for more detailed histopathological analysis. These lungs were enlarged, did not collapse, and in some instances, contained a small amount of foamy fluid within the respiratory tract. Six (3.17%) of the 189 suspected lung samples showed histopathological lesions indicating ovine pulmonary adneomatosis (OPA). These 6 lungs macroscopically were so heavy and “waterlogged”. The damaged lung areas were solid and light grey, particularly in the ventral region or diaphragmatic lobes. All 6 affected lungs had consistent histopathological characteristics and displayed typical lesions associated with atypical OPA. These features included papillary projections within the bronchioles and alveoli, sparse connective tissue stroma, infiltration of mononuclear cells and connective tissue, as well as swollen, foamy macrophages in the alveoli and bronchioles near the neoplastic lesions. In one instance, in addition to these changes, a prominent feature of the classic OPA form was noted, characterized by the presence of fibrin casts and neutrophils in the bronchial and alveolar lumens. The affected regions were largely similar and aligned with findings reported in other studies. All 6 affected lungs were from sheep older than 2 years. There is often no clear distinction between atypical and classical OPA cases, and both forms can sometimes be found within the same lung. | ||
| کلیدواژه‌ها | ||
| Ovine pulmonary adenocarcinoma؛ slaughterhouse؛ histopathology | ||
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آمار تعداد مشاهده مقاله: 283 تعداد دریافت فایل اصل مقاله: 113 |
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