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Antifungal and Demelanizing Activity of Ganoderma lucidum on Some Pathogenic Fungi, and Electron Microscopic Study of Fungal Damage | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 12 مهر 1404 اصل مقاله (359.05 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2025.369197.3623 | ||
| نویسندگان | ||
| Sayeh Jamadi Khiyabani1؛ pegah shakib2؛ Mahboobeh Madani* 1؛ Seyed Masoud Hashemi Karouei3 | ||
| 1Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran. | ||
| 2Department of Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. | ||
| 3Department of Microbiology, Babol Branch, Islamic Azad University, Babol, Iran. | ||
| چکیده | ||
| In the last two decades, fungal diseases have increased for various reasons, including weakened immune systems, overuse of antibiotics, antifungals, and corticosteroids, as well as increased longevity. Ganoderma lucidum has a variety of biologically active compounds with medicinal functions. The present study aimed to investigate the antimicrobial and demelanizing activity of Ganoderma lucidum on somepathogenic fungi and to assess the damage by scanning electron microscopy(SEM). In this study,After preparing methanolic and chloroform extracts of Ganoderma lucidum ,antifungal activities of methanolic and chloroform extracts were separately evaluated on Sporothrix schneckei, Alternaria alternata, Mucor, Penicillium, and Trichophyton violaceum based on growth inhibition percentage. Also, inhibition of melanin production of Ganoderma lucidum was investigated on these fungi. Furthermore, the damage caused by the extracts on these fungi was studied by scanning electron microscopy(SEM). According to the results, the mean percentage of growth inhibition of methanolic extract were 67.25±1.02, 100.00±.00, 27.92±3.00, 100.00±.00, and 100.00±.00 for Sporothrix schneckei, Alternaria alternata, Mucor, Penicillium, and Trichophyton violaceum, respectively, and 83.82±14.16, 100.00±.00, 47.92±3.61, 100.00±.00, and zero for the chloroform extract. Ganoderma lucidum inhibited the production of melanin with Penicillium. Based on scanning electron microscope(SEM) observations, changes in morphology, production of pores shrinkage at the surface of the mycelium and conidia, and a decrease in the number of conidia were observed. According to the results, Ganoderma lucidum is a valuable mushroom with an antifungal effect against fungal pathogens and might be used to treat these diseases. However, more research is needed to investigate the possible side effects of consuming it. | ||
| کلیدواژه‌ها | ||
| Ganoderma lucidum؛ Antifungal effect؛ Demelanizing؛ Scanning electron microscope(SEM) | ||
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