| تعداد نشریات | 285 |
| تعداد نشریات سازمان | 83 |
| تعداد شمارهها | 3,133 |
| تعداد مقالات | 34,831 |
| تعداد مشاهده مقاله | 50,191,189 |
| تعداد دریافت فایل اصل مقاله | 84,716,946 |
The effect of niosome nanosystem containing Satureja khuzistanica extract on antioxidant and antimicrobial properties | ||||||
| Journal of Organic Farming of Medicinal Plants | ||||||
| دوره 3، شماره 2 - شماره پیاپی 2980، شهریور 2024، صفحه 59-71 اصل مقاله (774.01 K) | ||||||
| نوع مقاله: Original Article | ||||||
| نویسندگان | ||||||
| Mirabolghasem Miri1؛ Fahimeh Najafi* 2؛ Ali Asghar Bagheri Keshtali3 | ||||||
| 11Master's student, Department of Chemistry, Ro.C., Islamic Azad University, Roudehen, Iran. | ||||||
| 2Department of Chemistry, Ro.C., Islamic Azad University, Roudehen, Iran | ||||||
| 33Department of biology, Ro.C., Islamic Azad University, Roudehen, Iran | ||||||
| چکیده | ||||||
| Background and Objective: design and development of novel drug delivery systems has been considered as an effective strategy to improve efficacy of drugs and reduce their toxicity in target tissue. In this regard, niosomes as nanoparticle carriers with unique properties such as biodegradability, non-toxicity, and targeted drug delivery capability have been proposed as a promising option. The aim of this study is to investigate antimicrobial and antioxidant effects of niosomes containing Satureja khuzistanica extract on microbial pathogens and cancer cells. Materials and Methods: In this study, niosomes were first prepared by thin-layer hydration method, then properties of nanoparticles were determined by SEM. The amount of drug release was measured with a dialysis bag. Drug release was evaluated dynamically and finally antimicrobial activity of the niosomal Nano system of Satureja khuzistanica extract was determined using MIC and MBC in comparison with its free form. Antioxidant activity was determined by two methods, DPPH and ABTS, for niosomal Nano system form in comparison with free form. Results: results showed that synthesized nanoparticles had a spherical structure and aggregation and agglomeration were observed in some places. Cumulative release of extract in PBS-SDS medium showed that over 72 hours, the rate of extract release from niosomes was less than its free form; so that over 48 and 72 hours, 54% and 56% of extract was released from niosomal Nano carriers, respectively. Also, evaluation of antioxidant activity in both methods for niosomal Nano carriers containing extract has a higher recovery percentage than free extracts. Conclusion: Niosomes prepared from Satureja khuzistanica show property of inhibiting and controlling microbial and anticancer activity and can be used as an effective drug delivery system in treatment of microbial infections and cancer. These findings can be basis for future research in field of developing natural medicines and new drug delivery systems | ||||||
| کلیدواژهها | ||||||
| antibacterial؛ controlled release؛ extract؛ niosomes؛ antioxidant؛ targeted drug delivery | ||||||
| مراجع | ||||||
|
Akbari, J., Saeedi, M. and Enayatifard, R. 2020. Curcumin Niosomes (curcusomes) as an alternative to Conventional Vehicles: A potential for efficient dermal delivery. Journal of Drug Delivery Science and Technology, 60, 1 02035.
Akbarzadeh, I., Keramati, M., Azadi, A., Afzali, E., Shahbazi, R., Norouzian, D., et al. (2021). Optimization, physicochemical characterization, and antimicrobial activity of a novel simvastatin nano-niosomal gel against E . Coli and S. aureus. Chemistry and Physics of Lipids, 234, 105019.
Akhlaghi, M., Ebrahimpour, M., Ansari, K., Parnian, F., Zarezadeh Mehrizi, M. and Taebpour, M. 2021. Synthesis,study and characterization of nano niosomal system containing Glycyrrhiza glabra extract in order to improve it’s the rapeutic eff ects. New Cellular and Molecular Biotechnology Journal, 11(42), 65– 82.
Akhlaghi, M., Taebpour, M., Nikoonahad Lotfabadi, N., and et al. (2022). Synthesis and characterization of smart stimuli responsive herbal drug encapsulated nanoniosome particles for effi cient treatmentof breast cancer. Nanotechnology Reviews, 11, 1364 –1385.
Alemi, A., Zavar Reza, J., Haghiralsadat, F., Zarei Jaliani, H., Haghi Karamallah, M., Hosseini, S.A., et al.( 2018).paclitaxel and curcumin coadministration in novel cationic PEGylated niosomal for-mulations exhibit enhanced synergistic antitumor efficacy. Journal of Nanobiotechnology, 16 (1),1– 20.
Amini, B., Karamat, J., Hojatoleslami, M., Jahadi, M. and Mahmudian, K. 2015. Evaluation of antioxidant properties of savory essential oil in rapeseed oil and kilka fish oil. Food technology and Nutrition, 12(3), 29 -38.
Amiri, B., Ahmadvand, H., Farhadi, A., Najmafshar, A., Chiani, M. and Norouzian, D. 2018. Delivery of vinblastine containing niosomes results in potent in vitro/in vivo cytotoxicity on tumor cells. Drug Development and Industrial Pharmacy, 44(8), 1371-1376.
Anuj, A., Gajera, H.P., Hirpara, D.G. and Golakiya, B.A. 2019. Bacterial membrane destabilization with cationic particles of nano-silver to combat efflux-mediated antibiotic resistance in gram-negative bacteria. Life Sciences, 230, 178–187.
Appalasamy, S. and Yann, L.K. 2014. Antimicrobial activity of Artemisinin and precursor derived from in vitro plantlets of Artemisia annua L. BioMed Research International, 3, 16-28.
Arunachalam, K., Pandurangan, P., and et al.(2023). Regulation of Staphylococcus aureus Virulence and Application of Nanotherapeutics to Eradicate S. aureus Infection. Pharmaceutics, 15(2), 310.
Azaz, A.D., Kurkcuoglu, M., Satil, F., Baser, K.H.C. and Tumen, G. 2005. In vitro antimicrobial activity and chemical composition of some Satureja essential oils. Flavour and Fragrance Journal, 20(6), 587-591.
Azizbek, K.M., Hamid AbdulHussein, A., Edrees Fadhil, A., and et al.(2023).Systematic Review of Drug Nanocarriers in Breast Cancer Treatment: Focusing on Liposomes and Polymeric Nanoparticles. Journal of Nanostructures,13(4), 960-977.
Barani, M., Paknia, F., and et al. (2023). Niosome as an Effective Nanoscale Solution for the Treatment of Microbbial Infections. BioMed Research International, 1-18.
Bartelds, R. 2018. Niosomes, an alternative for liposomal delivery. Public Library of Science ONE, 13(4), 0194179.
Blumenthal, M. and Glodberg, A.J. (2000).Brinckmann, Herbal Medicine. Integrative Medicine Communications.united State of America, 574-592.
Bobo, D., Robinson, K.J., Islam, J., Thurecht, K.J. and Corrie, S.R. 2016. Nanoparticle-Based Medicines: A Review of FDA Approved Materials and Clinical Trials to Date. Pharmacological Research, 33, 2373-87.
Chambre, D.R., Moisa, C., Lupitu, A., Copolivici, L., Pop, G. and Copolivici, D.M. 2020. Chemical composition, antioxidant capacity, and thermal behavior of Satureja hortensis essential oil. Scientific Reports, 10, 21322.
Che, X., Lei, S., and et al.(2022). Stimuli-responsive image-guided nanocarriers as smart drug delivery platforms. Expert Opinion on Drug Delivery, 19(11), 1487-1504.
Chen, H., Guan, X., Liu, Q., Yang, L. and Guo, J. 2022. Co-assembled Nanocarriers of De Novo Thiol-Activated Hydrogen Sulfide Donors with an RGDFF Pentapeptide for Targeted Therapy of Non-Small-Cell Lung Cancer. ACS Applied Materials & Interfaces, 14 (48), 53475–53490.
Chen, L., Zhou, Z., and et al. (2022). Platelet membrane-coated nanocarriers targeting plaques to deliver anti-CD47 antibody for atherosclerotic therapy, RESEARCH, 17, 1-12.
Chen, N., Sun, J., Zhu, Z. and Cribbs, A.P. 2022. Edible plant-derived nanotherapeutics and nanocarriers: recent progress and future directions, Expert Opinion on Drug Delivery, 19(4).409-419.
Devara, S., Bhamidipati, S., and et al.(2023). Antibacterial activity of cinnamon extract against gram-positive and gramnegative bacterial pathogens isolated from patient samples. Medical Laboratory, 17(6), 1-4.
Estabragh, M.A., Pardakhty, A., Ahmadzadeh, S., Dabiri, S., Afshar, R.M. and Abbasi, M.F. 2022. Successful Application of Alpha Lipoic Acid Niosomal Formulation in Cerebral Ischemic Reperfusion Injury in RatModel. Advanced pharmaceutical Bulletin, 12(3), 541.
Ghaderi,, R.S., Kazemi, M. and, Soleimanpour, S. 2021. Nanoparticles are more successful competitor than antibiotics in treating bacterial infections: a review of the literature. Iranian Journal of Medical Microbiology, 15(1), 18-45.
Ghafelehbashi, R., Akbarzadeh, I., Tavakkoli Yaraki, M., Lajevardi, A., Fatemizadeh, M. and Heidarpoor Saremi, L. 2019. Preparation, physicochemical properties, in vitro evaluation and release behavior of cephalexin-loaded niosome. International Journal of Pharmaceutics, 569, 118580.
Habibi, O. and Alizadeh, F. 2016. the Sixth Conference of Graduate Students and the Second Conference of Students of Mashhad University of Medical Sciences, https://www.sid.ir/FileServer/SF/7001394h06164.
Hedayati, C.H.M. et al. (2021). Niosome-encapsulated tobramycin reduced antibiotic resistance and enhanced antibacterial activity against multidrug-resistant clinical strains of Pseudomonas aeruginosa. Journal of Biomedical Materials Research Part A,109(6), 966–980.
Hajhashemi, V., Ghannadi, A. and Pezeshkian, S.K. 2002. Antinociceptive and anti-inflammatory effect of Satureja hortensis L., extracts and essential oil. Journal of Ethnopharmacology, 82(2-3), 83-87.
Hamishehkar, H., Rahimpour, Y. and Kouhsoltani, M. 2013. Niosomes as a propitious carrier for topical drug delivery. Expert Opinion On Drug Delivery, 10(2), 261-272.
Jamal, M., Imam, S.S., Aqil, M., Amir, M., Mir, S.R. and Mujeeb, M. 2015. Transdermal potential and anti-arthritic efficacy of ursolic acid from niosomal gel systems. International Immunopharmacology, 29 (2), 361-369.
Jankie, S., Johnson, J., Adebayo, A.S., Pillai, G.K. and Pinto Pereira, L.M. 2020. Efficacy of levofloxacin loaded nonionic Surfactant vesicles (niosomes) in a model of Pseudomonas Aeruginosa infected Sprague Dawley rats. Advances in Pharmacological and Pharmaceutical Sciences, 8815969.
Karamian, R. and Kamalnejade, J. 2019. Green synthesis of silver nanoparticles using aqueous seed extract of cuminum cyminum L. and evaluation of their biological activities. Scientific Journal of Ilam University of Medical Sciences, 26( 5), 128–141.
Kashef, M.T., Nehal, M.S., Assar, N.H. and Ramadan, M.A. 2020 the antimicrobial activity of ciprofoxacin loaded niosomes against ciprofoxacin-resistant and bioflm-.taphylococcus aureus. Infection and Drug Resistance, 13, 1619–1629.
Khalil, M.A., Maghraby, G.M.E., and et al. (2021). Enhanced Efficacy of Some Antibiotics in Presence of Silver Nanoparticles against Multidrug Resistant Pseudomonas aeruginosa Recovered From Burn Wound Infections. Frontiers in Microbiology., 12, 648560.
Kaur, A., Preet, S., Kumar, V., Kumar, R. and Kumar, R. 2019. synergetic effect of vancomycin loaded silver nanoparticles for enhanced antibacterial activity. Colloids and Surfaces B: Biointerfaces,176, 62–69.
Mancini, E., Senatore, F., Del Monte, D., De Martino, L., Grulova, D., Scognamiglio, M., Snoussi, M. and De Feo, V. 2015. Studies on chemical composition, antimicrobial and antioxidant activities of five Thymus vulgarisL. Essential Oils Molecules, 20(7), 12016.
Mansouri, M., et al. (2021). Streptomycin sulfate-loaded niosomes enables increased antimicrobial and antibiofim Activities. Frontiers in Bioengineering and Biotechnology, 9, 745099.
Moshahary, S. and Mishra, P. 2020. Synthesis of silver nanoparticles (AgNPs) using culinary banana peel extract for the detection of melamine in milk. Journal of Food Science and Technology, 58, 797–804.
Nasseri B. (2005). Effect of cholesterol and temperature on the elastic properties of niosomal membranes.
International Journal of Pharmaceutics, 300(1-2), 95-101.
Omidbaigi, R. (2000). Production and processing of medicinal plants. Astane Qouds Publication. Tehran. Pp: 397.
Peer, D.M., Karp, J., Hong, S., Farokhzad, O.C. and et al., 2007. Nanocarriers as an emerging platform for cancer therapy. Nature nanotechnology, 2(12), 751-60.
Pourmahmoudian, M., Kalantar, S.M., Haghiralsadat, B.F. 2021. Design and Synthesis of a Highly Efficient Niosomal Drug Delivery System for Berberine Delivery to Osteosarcoma Cell Line (Saos-2). Journal of Mazandaran University of Medical Sciences, 31 (202), 25-37.
Priprem, A., Janpim, K., Nualkaew, S. and Mahakunakorn, P. 2016. TopicalNiosome Gel of Zingiber cassumunar Roxb Extract for Anti-inflammatory Activity Enhanced Skin Permeation and Stability of Compound D. AAPS Pharm SciTech, 17(3): 631-639.
Qi-Yao, W., Yan-Ming, X. and Lau T.V. 2020. Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies, Cancers, 12(10), 2783.
Radonic, A. and Milos, M. 2003. Chemical composition and in vitro evaluation of antioxidant effect of free volatile compounds from Satureja montana L. Free Radical Research, 37(6), 673-679.
Raeiszadeh, M., and et al. (2018). Development, physicochemical characterization, and antimicrobial evaluation of niosomal myrtle essential oil. Research in Pharmaceutical Sciences, 13(3), 250-261.
Raeiszadeh, M. 2016. Development, physicochemical characterization, and antimicrobial evaluation of niosoma-l myrtle essential oil. Research in Pharmaceutical Sciences, 1, 12-21.
Saeed Shah, H., Usman, F. and Ashfaq–Khan, M. 2020. Preparation and characterization of anticancer niosomal Withaferin –A formulation for improved delivery to cancer cells: In vitro, in vivo, and in silico evaluation. Journal of Drug Delivery Science and Technology, 59, 101863.
Sagdic, O., Karahan, A.G., et al. (2003). Note effect of some spices extracts on bacterial inhibition. Food Science and Technology International, 9, 353-359.
Samatiwat, P., Chankhonkaen, P., Jaisin, Y., Ratanachamnong, P., et al. (2021). anticancer activity of thebark extract of Phyllanthus emblica on cholangiocarcinomain vitro. Journal of Basic and Applied Pharmacology, 1, 60–71.
Sefidkon, F., Sadeghzadeh, L., Teimouri, M., et al. (2007). Essential oils of two Satureja species in two harvesting time. Iranian Journal of Medical Microbiology, 23, 174-182.
Serrentino, J. 1991. How Natural Remedies Work.Point Robert, W.A.: Harley and Marks Publishers, 20 -22.
Smith, R., Russo, J., et al. (2020). Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails, Antibiotics, 9(2), 56.
Smith, T., Affram, K., and et al. (2020).Application of smart solid lipid nanoparticles to enhance the efficacy of 5-flu-orouracil in the treatment of colorectal cancer. Scientific Reports, 10, 16989.
Sukri, M., Shameli, K., and et al, (2023) Enhanced antibacterial and anticancer activities of plant extract mediated green synthesized zinc oxide-silver nanoparticles. Frontiers in Microbiology, 14.
Swetha, V., Lavanya, S., Sabeena, G., Pushpalaksmi, E., Jenson, S.J. and Annadurai, G. 2020. Synthesis and characterization of silver nanoparticles from Ashyranthus aspera extract for antimicrobial activity studies. Journal of Applied Sciences and Environmental Management, 24(7), 1161–1167.
Tabatabaei Rasti, A.R., Khalighi, A., Kashi, A., et al. 2007. Antioxidant activity and chemical composition of essential oil of aerial part of Saturejasahendica Born. Iranian Journal of Pharmaceutical Sciences, 3, 1-6.
Targhi, A.A., et al. (2021). Synergistic efect of curcumin-Cu and curcumin-Ag nanoparticle loaded niosome: Enhanced antibacterial and anti-bioflm activities. Bioorganic Chemistry, 115, 105116.
Teimouri, M., Bahar, Z. and Mirza, M. 2003. Antimicrobial activity of essential oil of Satureja laxiflora G. Koch before and after flowering. Iranian Journal of Medicinal and Aromatic Plants, 13, 49-68.
Thabet, Y., Elsabahy, M. and Eissa, N.G. 2022. Methods for preparation of niosomes: A focus on thin-film hydtation method. Methods, 199, 9-15.
Vélez, E., Campillo, G., Morales, G., Hincapié, C., Osorio, J. and Arnache, O. 2018. Silver Nanoparticles Obtained by Aqueous or Ethanolic Aloevera Extracts : An Assessment of the Antibacterial Activity and Mercury Removal Capability. Journal of Nanomaterials, 4, 1-17.
Wang, L., Hu, C. and Shao, L. 2017. the antimicrobial activity of nanoparticles: present situation and prospects for the future, International Journal of Nanomedicine, 12, 1227-1249.
Wang, J., Seebacher, N., Shi, H., Kan, Q. and Duan, Z. 2017. Novel strategies to prevent the development of multi drug resistance (MDR) in cancer. Oncotarget, 8(48), 84559.
Weiss, R.F. and Fintelmann, V. 2000. Herbal Medicine, Thieme , Germany, 258-272.
Wichayapreechar, P., Anuchapreeda, S., Phongpradist, R., Rungseevijitprapa, W. and Ampasavate, C. 2020. Dermal targetiug of Centella asiatica extract using hyaluronic acid surface modified niosomes. Journal of Liposome Research, 30(2), 197-207.
Wolfram, J., Zhu, M., Yang, Y., Shen, J., Gentile, E., Paolino, D., et al.(2015).Safety of nanoparticles in medicine. Current Drug Targets, 16(14), 1671-1681.
Yaghoobian, M., Haeri, A., Bolourchian, N., et al. 2020. The impact of surfactant composition and surface charge of niosomes on the oral absorption of repaglinide as a BCS II model drug. International Journal of Nanomedicine, 11, 8767-81.
Yakhchi, V., Jahanizadeh, S., Yazdian, F., and et al. 2020. Synthesis and Evaluation of Lipid-based Nanoparticle containining Ginger Extract against Aspergillus Species. Journal of Shahid Sadoughi University of Medical Sciences, 28 (6), 2766 - 2780 .
Yeo, P.L., Lim, C.L., Chye, S.M., Kiong Ling, A.P. and Koh, R.Y. 2017. Niosomes: a review of their
Ying-Qi, X. and Chen, W. 2016. Niosome encapsulation of curcumin: characterization and cytotoxic effect on ovarian cancer cells. Journal of Nanomaterials, 63, 2-16.
| ||||||
|
آمار تعداد مشاهده مقاله: 42 تعداد دریافت فایل اصل مقاله: 28 |
||||||