Attarpour Yazdi, M., Kamalinejad, M., Falvaei Koochak, N., Mansouri, S. (2009). Antibacterial activity of Terminalia catappa L. extract against bacteria isolated from burn wounds and comparison with effects of selective antibiotics in vitro. , 25(3), 386-397. doi: 10.22092/ijmapr.2009.7177
M.M. Attarpour Yazdi; M. Kamalinejad; N.S. Falvaei Koochak; S. Mansouri. "Antibacterial activity of Terminalia catappa L. extract against bacteria isolated from burn wounds and comparison with effects of selective antibiotics in vitro". , 25, 3, 2009, 386-397. doi: 10.22092/ijmapr.2009.7177
Attarpour Yazdi, M., Kamalinejad, M., Falvaei Koochak, N., Mansouri, S. (2009). 'Antibacterial activity of Terminalia catappa L. extract against bacteria isolated from burn wounds and comparison with effects of selective antibiotics in vitro', , 25(3), pp. 386-397. doi: 10.22092/ijmapr.2009.7177
Attarpour Yazdi, M., Kamalinejad, M., Falvaei Koochak, N., Mansouri, S. Antibacterial activity of Terminalia catappa L. extract against bacteria isolated from burn wounds and comparison with effects of selective antibiotics in vitro. , 2009; 25(3): 386-397. doi: 10.22092/ijmapr.2009.7177

Antibacterial activity of Terminalia catappa L. extract against bacteria isolated from burn wounds and comparison with effects of selective antibiotics in vitro

تحقیقات گیاهان دارویی و معطر ایران
Article 10, Volume 25, Issue 3 - Serial Number 45, November 2009, Pages 386-397    PDF (191.78 K)
Document Type: Research Paper
DOI: 10.22092/ijmapr.2009.7177
Authors
M.M. Attarpour Yazdi* 1; M. Kamalinejad2; N.S. Falvaei Koochak3; S. Mansouri4
1Microbiology Department, Faculty of Medicine, Shahed University, Tehran, Iran
2Pharmacognosy Department, Faculty of Pharmacy, Shaheed Beheshti University, Tehran, Iran
3Azad University, Tehran, Iran
4Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran
Abstract
Burn wound is suitable site for incidence of resistant infections. Thus, the research for finding effective drugs against this problem is necessary. Medicinal herbs with antimicrobial activity have important role in traditional medicine. The purpose of this study was to determine antibacterial activity of methanolic extract of Terminalia catappa L. fruitagainst bacteria isolated from burn wound infections and to compare with effects of some selected antibiotics. First, a sample of methanolic extract of the Terminalia catappa fruit was prepared and then its antibacterial activity against 8 bacteria from 100 samples of burn wound infection were evaluated by well diffusion method at concentration of 40 mg/ml and then Agar Serial Dilution method in the range of 0.039-20mg/ml. Also, the MIC (Minimal Inhibitory Concentration) of extract was determined. The antibacterial activity of selective antibiotics was tested by disk diffusion method. The onava test was used to compare the results. The results from the antibacterial tests demonstrated that the Terminalia catappa methanolic extract had been effected against all of Pseudomonas aeruginosa, Acinetobacter spp. and more than 80% of Staphylococcus aureus/epidermidis/saprophyticus, and against 50% of Escherichia coli. The MIC of the extract against all the sensitive cases was 20 mg/ml. The bacteria were often resistant to selective drugs .There was significant difference between the effects of plant and antibiotics on Pseudomonas aeruginosa (P<0/001), Acinetobacter spp. (P<0/05) and Staphylococcus cases (P<0/05). This study demonstrated that methanolic extract of Terminalia catappa have excellent antibacterial activity against most of bacteria isolated from burn wound infections and its effect is better than selective antibiotics. However, we need more in vitro and in vivo investigation.
Keywords
Terminalia catappa L; Burn wound infection; methanolic extract; Antibacterial
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