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The inhibitory synergistic effects of verapamil and Satureja hortensis essential oil on cholinergic contraction of rat ileum | ||
| تحقیقات گیاهان دارویی و معطر ایران | ||
| Article 17, Volume 31, Issue 6 - Serial Number 74, February 2016, Pages 1096-1103 PDF (745.27 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.22092/ijmapr.2016.105897 | ||
| Authors | ||
| S.H. Hejazian* 1; F. Safari2; M. Bameri3 | ||
| 1Department of Physiology/Herbal Medicine Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran | ||
| 2Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran | ||
| 3Paradise University, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran | ||
| Abstract | ||
| Verapamil inhibits the cytosolic calcium content by blocking both activated and inactivated T-type calcium. Regarding the spasmolytic effect of materials caused by blockage of calcium channels and due to the inhibitory effect of Satureja hortensis L. on ileum smooth muscle contraction. The present study was designed to find out the synergistic effects of calcium blocker verapamil and Satureja essential oil on inhibition of cholinergic contraction in male rat’s ileum. In this study, by using an oscillographic device, the effects of different concentration of Satureja essential oil and verapamil were examined on isotonic contraction of ileum induced by acetylcholine10-4M. Our results showed that both verapamil and Satureja essential oils inhibited acetylcholine-induced contraction of ileum. In addition, their ineffective doses had synergistic spasmolytic effects, which were statistically significant (p<0.05). | ||
| Keywords | ||
| Verapamil; Satureja hortensis L; essential oil; spasmolythic; acetylcholine; ileum; smooth muscle | ||
| References | ||
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