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Hasan, M. F, Jawad Kadhim, M, Al-Awady, M. J. (1402). The Impact of Berberine Loaded Selenium Nanoparticles on K. pneumoniae and Candida albicans Antibiotics Resistance Isolates. سامانه مدیریت نشریات علمی, 78(3), 1005-1015. doi: 10.22092/ari.2022.359898.2509
M. F Hasan; M Jawad Kadhim; M. J Al-Awady. "The Impact of Berberine Loaded Selenium Nanoparticles on K. pneumoniae and Candida albicans Antibiotics Resistance Isolates". سامانه مدیریت نشریات علمی, 78, 3, 1402, 1005-1015. doi: 10.22092/ari.2022.359898.2509
Hasan, M. F, Jawad Kadhim, M, Al-Awady, M. J. (1402). 'The Impact of Berberine Loaded Selenium Nanoparticles on K. pneumoniae and Candida albicans Antibiotics Resistance Isolates', سامانه مدیریت نشریات علمی, 78(3), pp. 1005-1015. doi: 10.22092/ari.2022.359898.2509
Hasan, M. F, Jawad Kadhim, M, Al-Awady, M. J. The Impact of Berberine Loaded Selenium Nanoparticles on K. pneumoniae and Candida albicans Antibiotics Resistance Isolates. سامانه مدیریت نشریات علمی, 1402; 78(3): 1005-1015. doi: 10.22092/ari.2022.359898.2509

The Impact of Berberine Loaded Selenium Nanoparticles on K. pneumoniae and Candida albicans Antibiotics Resistance Isolates

Archives of Razi Institute
مقاله 28، دوره 78، شماره 3، مرداد و شهریور 2023، صفحه 1005-1015    اصل مقاله (929.91 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359898.2509
نویسندگان
M. F Hasan1؛ M Jawad Kadhim1؛ M. J Al-Awady1، 2
1Department of Biotechnology, College of Biotechnology, Al-Qasim Green University, Babylon, Iraq
2Department of Chemistry, Faculty of Science, University of Western Ontario, 1151 Richmond Street, London ON, N6A 5B7, Canada
چکیده
This study aimed to investigate the antibacterial and antifungal activities of selenium nanoparticles (SeNPs) and berberine (BBR) despite antibiotic resistance against Klebsiella pneumoniae and Candida albicans. Cells of K. pneumoniae and C. albicans were treated with solutions of different concentrations of each bare SeNPs, BBR, and BBR-loaded SeNPs (BLS) using the disk diffusion method. The results indicated that the activities of SeNPs, BBR, and BLS were statistically significant (P<0.05) when the concentration of all agents increased. Moreover, it was found that BLS had a statistically significant effect against K. pneumoniae and C. albicans, compared to SeNPs and BBR alone (P<0.05). The largest zones of inhibition of SeNPs were 14 and 16 mm toward K. pneumoniae and C. albicans, respectively, at the concentration of 20 Mml, compared to the concentrations of 10 and 15 Mml. Furthermore, BBR showed a maximum zone of inhibition at the concentration of 1,200 mg (15 mm for K. pneumoniae and 18 mm for C. albicans) and it was statistically significant in comparison with other concentrations of 400 and 800 mg. In addition, the BLS underwent a statistically significant increase (P<0.05) when the concentration increased and it registered a large zone of inhibition of 22 and 25 mm against K. pneumoniae and C. albicans, respectively, at 20 Mml of SeNPs: 1,200 mg BBR, compared to 10 Mml of SeNPs: 400 mg BBR and 15 Mml of SeNPs: 800 mg BBR. Based on the results of the current study, there was a statistically synergistic effect of BBR-loaded SeNPs, compared to that of BBR and Se nanoparticles, only in the case of both K. pneumoniae and C. albicans. This study is promising as a blueprint for the enhancement of weak antimicrobial agents and their return to their previous role as antibiotics.
کلیدواژه‌ها
Berberine؛ Candida albicans؛ K. pneumoniae؛ Selenium nanoparticles
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مراجع
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